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Systems biology and cancer stem cells [PDF]

open access: yesJournal of Cellular and Molecular Medicine, 2007
Introduction Molecular profiling for cancer classification Molecular profiling of cancer stem cells Emerging technologies for proteome characterization Biomolecular networks in cancer Perspective and concluding remarks AbstractThe identification, purification and characterization of cancer stem cells (CSCs) holds tremendous promise for improving the
Nathan D. Price   +4 more
openaire   +3 more sources

An inter‐species protein–protein interaction network across vast evolutionary distance

open access: yesMolecular Systems Biology, 2016
In cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions ...
Quan Zhong   +30 more
doaj   +1 more source

Nanotechnology and cancer [PDF]

open access: yes, 2008
The biological picture of cancer is rapidly advancing from models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level.
Davis, Mark E., Heath, James R.
core   +2 more sources

Artificial Intelligence (AI)-Based Systems Biology Approaches in Multi-Omics Data Analysis of Cancer

open access: yesFrontiers in Oncology, 2020
Cancer is the manifestation of abnormalities of different physiological processes involving genes, DNAs, RNAs, proteins, and other biomolecules whose profiles are reflected in different omics data types.
Nupur Biswas, S. Chakrabarti
semanticscholar   +1 more source

Systems Biology and Genomics of Breast Cancer [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2010
It is now accepted that breast cancer is not a single disease, but instead it is composed of a spectrum of tumor subtypes with distinct cellular origins, somatic changes, and etiologies. Gene expression profiling using DNA microarrays has contributed significantly to our understanding of the molecular heterogeneity of breast tumor formation ...
Charles M. Perou   +1 more
openaire   +2 more sources

Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]

open access: yes, 2018
The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B.   +2 more
core   +3 more sources

Cyclin-dependent kinases as drug targets for cell growth and proliferation disorders. A role for systems biology approach in drug development. Part II - CDKs as drug targets in hypertrophic cell growth. Modelling of drugs targeting CDKs [PDF]

open access: yes, 2012
Cyclin-dependent kinases (CDKs) are key regulators of cell growth and proliferation. Impaired regulation of their activity leads to various diseases such as cancer and heart hypertrophy.
Idowu, Michael A.
core   +2 more sources

Network-based prediction of protein interactions

open access: yesNature Communications, 2019
Computational protein-protein interaction (PPI) prediction has the potential to complement experimental efforts to map interactomes. Here, the authors show that proteins tend to interact if one is similar to the other’s partners and that PPI prediction ...
István A. Kovács   +12 more
doaj   +1 more source

ATM in focus:a damage sensor and cancer target [PDF]

open access: yes, 2012
The ability of a cell to conserve and maintain its native DNA sequence is fundamental for the survival and normal functioning of the whole organism and protection from cancer development.
Khalil, Hilal S.   +2 more
core   +4 more sources

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]

open access: yes, 2019
Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J   +4 more
core   +2 more sources

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