Systems biology and cancer: Promises and perils [PDF]
Progress in Biophysics and Molecular Biology, 2011 Systems biology uses systems of mathematical rules and formulas to study complex biological phenomena. In cancer research there are three distinct threads in systems biology research: modeling biology or biophysics with the goal of establishing plausibility or obtaining insights, modeling based on statistics, bioinformatics, and reverse engineering ...
Barnett S. Kramer, Stuart G. Baker
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Nanotechnology and cancer [PDF]
, 2008 The biological picture of cancer is rapidly advancing from models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level.
Davis, Mark E., Heath, James R.
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Development of OX40 agonists for canine cancer immunotherapy
iScience, 2022 Summary: Recent breakthroughs in cancer immunotherapy have provided unprecedented clinical benefits to human cancer patients. Cancer is also one of the most common causes of death in pet dogs.
Damien Ruiz +10 more
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Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance [PDF]
, 2015 Seliciclib (R-Roscovitine) was identified as an inhibitor of CDKs and has undergone drug development and clinical testing as an anticancer agent. In this review, the authors describe the discovery of Seliciclib and give a brief summary of the biology of ...
Cavicchi, Laura +4 more
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Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics
iScience, 2023 Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto +9 more
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Integration of proteomics into systems biology of cancer [PDF]
WIREs Systems Biology and Medicine, 2012 AbstractDeciphering the complexity and heterogeneity of cancer, benefits from integration of proteomic level data into systems biology efforts. The opportunities available as a result of advances in proteomic technologies, the successes to date, and the challenges involved in integrating diverse datasets are addressed in this review.
Mark J. Schliekelman +3 more
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Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]
, 2018 The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B. +2 more
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Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]
, 2019 Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J +4 more
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Pioneer factors in development and cancer
iScience, 2021 Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
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Mathematical models for chemotaxis and their applications in self-organisation phenomena [PDF]
, 2018 Chemotaxis is a fundamental guidance mechanism of cells and organisms, responsible for attracting microbes to food, embryonic cells into developing tissues, immune cells to infection sites, animals towards potential mates, and mathematicians into biology.
Painter, K. J.
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