Results 41 to 50 of about 15,755,427 (366)

Dose calculation algorithms in external beam photon radiation therapy [PDF]

open access: yes, 2013
This article is an editorial, and it doesn't include an abstract. Full text of this article is also available in HTML and PDF.Cite this article as:Lu L. Dose calculation algorithms in external beam photon radiation therapy.
Lu, Lanchun; Department of Radiation Oncology, The James Cancer Hospital, Ohio State University, Columbus, Ohio, USA.
core   +1 more source

Impact of heterogeneities on lateral penumbra in uniform scanning proton therapy [PDF]

open access: yes, 2013
Purpose: In the treatment planning of uniform scanning proton therapy, an aperture block is designed for each beam with a margin, which typically includes the lateral penumbra measured in water (homogenous) medium.
Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City   +1 more
core   +1 more source

Frequent adaptive immune responses against arginase-1

open access: yesOncoImmunology, 2018
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite   +9 more
doaj   +1 more source

Online adaptive radiotherapy for bladder cancer using a simultaneous integrated boost and fiducial markers

open access: yesRadiation Oncology, 2023
Purpose The aim was to assess the feasibility of online adaptive radiotherapy (oART) for bladder cancer using a focal boost by focusing on the quality of the online treatment plan and automatic target delineation, duration of the workflow and performance
Sana Azzarouali   +10 more
doaj   +1 more source

Modulating Glycolysis to Improve Cancer Therapy

open access: yesInternational Journal of Molecular Sciences, 2023
Cancer cells undergo metabolic reprogramming and switch to a ‘glycolysis-dominant’ metabolic profile to promote their survival and meet their requirements for energy and macromolecules.
C. Chelakkot   +3 more
semanticscholar   +1 more source

Cardiotoxicity and Cancer Therapy [PDF]

open access: yesAngiology, 2013
A fundamental concept of treatment is to do no harm. However, with cancer treatment this is not always possible. Chemotherapy is associated with cardiovascular (CV) complications.1,2 This risk is even greater in the elderly patients and patients with established CV disease.
Vasiliadis, I   +2 more
openaire   +3 more sources

Intensity modulated radiotherapy versus volumetric modulated arc therapy in breast cancer: A comparative dosimetric analysis [PDF]

open access: yes, 2015
Purpose: Intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) has the capacity to optimize the dose distribution. We analyzed the dosimetric differences of plans in treatment planning system (TPS) between VMAT and IMRT in ...
Soubhagya, Bhudevi; Basavataram Indo-American Cancer Institute and Research center, Hyderabad   +2 more
core   +1 more source

An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma

open access: yesOncoImmunology, 2021
Cells in the tumor microenvironment of Follicular lymphoma (FL) express checkpoint molecules such as programmed death ligands 1 and 2 (PD-L1 and PD-L2) and are suppressing anti-tumor immune activity.
Uffe Klausen   +18 more
doaj   +1 more source

Unlocking the potential of antibody–drug conjugates for cancer therapy

open access: yesNature Reviews Clinical Oncology, 2021
Nine different antibody–drug conjugates (ADCs) are currently approved as cancer treatments, with dozens more in preclinical and clinical development. The primary goal of ADCs is to improve the therapeutic index of antineoplastic agents by restricting ...
J. Drago, S. Modi, S. Chandarlapaty
semanticscholar   +1 more source

Patient-derived xenograft models in cancer therapy: technologies and applications

open access: yesSignal Transduction and Targeted Therapy, 2023
Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority in recapitulating the characteristics of cancer, such as the spatial structure of cancer and the ...
Yi-Han Liu   +5 more
semanticscholar   +1 more source

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