Results 41 to 50 of about 6,963,646 (317)

Actionability classification of variants of unknown significance correlates with functional effect

npj Precision Oncology, 2023
Genomically-informed therapy requires consideration of the functional impact of genomic alterations on protein expression and/or function. However, a substantial number of variants are of unknown significance (VUS).
Amber Johnson, Patrick Kwok-Shing Ng, Michael Kahle, Julia Castillo, Bianca Amador, Yujia Wang, Jia Zeng, Vijaykumar Holla, Thuy Vu, Fei Su, Sun-Hee Kim, Tara Conway, Xianli Jiang, Ken Chen, Kenna R. Mills Shaw, Timothy A. Yap, Jordi Rodon, Gordon B. Mills, Funda Meric-Bernstam   +18 more
doaj   +1 more source

Treatment planning study comparing proton therapy, RapidArc and intensity modulated radiation therapy for a synchronous bilateral lung cancer case

, 2014
Purpose: The main purpose of this study is to perform a treatment planning study on a synchronous bilateral non-small cell lung cancer case using three treatment modalities: uniform scanning proton therapy, RapidArc, and intensity modulated radiation ...
Zheng, Yuanshui; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Zhao, Li; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Risalvato, Dina; Department of Medical Dosimetry, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA., Vargas, Carlos; Radiation Oncology, Proton Collaborative Group (PCG), Bloomington, Indiana, USA., Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Pokharel, Shyam; Department of Medical Physics, 21st Century Oncology, Fort Myers, Florida, USA., Cersonsky, Nancy; Department of Radiation Oncology, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA.   +6 more
core   +1 more source

Clinical dosimetric impact of Acuros XB and analytical anisotropic algorithm (AAA) on real lung cancer treatment plans : review [PDF]

, 2014
Photon dose calculation algorithms in treatment planning system could affect the accuracy of dose delivery when tissue heterogeneity is involved along the beam path.
Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA.
core   +1 more source

Individualizing cancer therapy [PDF]

Leukemia & Lymphoma, 2010
In this issue of Leukemia and Lymphoma, Ngo and colleagues describe the predictive value of cyclin D1 expression as a predictor of bortezomib response in multiple myeloma. The ability to predict treatment response based on genetic expression would be of value, if it could be confirmed in a larger study.
Morie A, Gertz, Tamar, Tadmor
openaire   +2 more sources

Long-term effectiveness of adjuvant Goserelin in premenopausal women with early breast cancer [PDF]

, 2009
BACKGROUND: Systematic reviews have found that luteinizing hormone-releasing hormone (LHRH) agonists are effective in treating premenopausal women with early breast cancer.
Fornander, T, S. Forsyth, Johansson, Ulla,, T. Fornander, U. Johansson, Reczko, Krystyna,, B. Nordenskjold, Nordenskjold, Bo, Fornander, Tommy,, K. Reczko, Reczko, Krystyna, Fohlin, H, Hackshaw, Allan, Fornander, Tommy, Fohlin, Helena,, Valentini, Miriam,, H. Fohlin, Sainsbury, R, Fohlin, Helena, Johansson, U, Monson, Kathryn,, Reczko, K, M. Valentini, Forsyth, Sharon, Sainsbury, Richard,, Nicolucci, A, Monson, K, R. Sainsbury, Baum, M, Sainsbury, Richard, Valentini, Miriam, A. Hackshaw, Nordenskjöld, Bo,, Forsyth, Sharon,, M. Baum, A. Nicolucci, Nordenskjold, B, Fornander, T,, K. Monson, Johansson, Ulla, Nicolucci, Antonio,, Baum, Michael,, Baum, Michael, Hackshaw, Allan,, Hackshaw, A, Valentini, M, Monson, Kathryn, Nicolucci, Antonio, Forsyth, S   +48 more
core   +2 more sources

Current Landscape of Sonodynamic Therapy for Treating Cancer

, 2021
Recent advancements have tangibly changed the cancer treatment landscape. However, curative therapy for this dreadful disease remains an unmet need. Sonodynamic therapy (SDT) is a minimally invasive anti-cancer therapy involving a chemical sonosensitizer
Kaori Kusuda, Jun Okamoto, Shuji Kitahara, Yuki Horise, Yoshihiro Muragaki, Ken Masamune, Toshihiro Yamaguchi   +6 more
core   +1 more source

A TCR-based Chimeric Antigen Receptor

Scientific Reports, 2017
Effector T cells equipped with engineered antigen receptors specific for cancer targets have proven to be very efficient. Two methods have emerged: the Chimeric Antigen Receptors (CARs) and T-cell Receptor (TCR) redirection.
Even Walseng, Hakan Köksal, Ibrahim M. Sektioglu, Anne Fåne, Gjertrud Skorstad, Gunnar Kvalheim, Gustav Gaudernack, Else Marit Inderberg, Sébastien Wälchli   +8 more
doaj   +1 more source

Assessment of a Therapeutic X-ray Radiation Dose Measurement System Based on a Flexible Copper Indium Gallium Selenide Solar Cell

Sensors, 2022
Several detectors have been developed to measure radiation doses during radiotherapy. However, most detectors are not flexible. Consequently, the airgaps between the patient surface and detector could reduce the measurement accuracy.
Dong-Seok Shin, Tae-Ho Kim, Jeong-Eun Rah, Dohyeon Kim, Hye Jeong Yang, Se Byeong Lee, Young Kyung Lim, Jonghwi Jeong, Haksoo Kim, Dongho Shin, Jaeman Son   +10 more
doaj   +1 more source

Proton Therapy in the Management of Pancreatic Cancer [PDF]

, 2022
SIMPLE SUMMARY: Radiation treatment plays a pivotal a role in the management of pancreatic cancer, mainly in the neoadjuvant setting for borderline resectable tumors and in the definitive setting for unresectable localized disease. Most of the studies on
Hilal, Lara, Kobeissi, Jana M., Charles B. Simone, Jana M. Kobeissi, Haibo Lin, Carla Hajj, Lin, Haibo, Simone, Charles B., Lara Hilal, Hajj, Carla   +9 more
core   +1 more source

Dosimetric feasibility of moderately hypofractionated/dose escalated radiation therapy for localised prostate cancer with intensity-modulated proton beam therapy using simultaneous integrated boost (SIB-IMPT) and impact of hydrogel prostate-rectum spacer

Radiation Oncology, 2022
Purpose To examine the dosimetric feasibility of hypofractionated/dose escalated radiation therapy in patients with localized prostate carcinoma using simultaneous integrated boost intensity-modulated proton beam therapy (SIB-IMPT) in absence or presence
Dalia Ahmad Khalil, Danny Jazmati, Dirk Geismar, Jörg Wulff, Christian Bäumer, Paul Heinz Kramer, Theresa Steinmeier, Stefanie Schulze Schleitthoff, Sandija Plaude, Martin Bischoff, Stephan Tschirdewahn, Boris Hadaschik, Beate Timmermann   +12 more
doaj   +1 more source