Results 21 to 30 of about 1,972,453 (318)

Non-chemotherapy adjuvant agents in TP53 mutant Ewing sarcoma

Scientific Reports, 2023
Ewing sarcoma (EWS) is a malignant tumor arising in bone or soft tissue that occurs in adolescent and young adult patients as well as adults later in life.
Jin-Ah Kim, Kenneth A. Crawford, Piero A. Spada, Leah R. Martin, Jiaqi Zhang, Rain Wong, Joel M. Reid, Clinton F. Stewart, Timothy M. Frank, Qianqian Liu, Joel E. Michalek, Charles Keller   +11 more
doaj   +1 more source

Immunotoxin therapy of cancer [PDF]

Nature Reviews Cancer, 2006
Rationally designed anticancer agents that target cell-surface antigens or receptors represent a promising approach for treating cancer patients. However, antibodies that bind these targets are often, by themselves, non-cytotoxic. By attaching potent toxins we can dramatically improve the clinical utility of some anti-tumour antibodies.
Pastan, Ira, Hassan, Raffit, FitzGerald, David J., Kreitman, Robert J.   +3 more
openaire   +2 more sources

Quality management in radiation therapy: A 15 year review of incident reporting in two integrated cancer centres

Technical Innovations & Patient Support in Radiation Oncology, 2020
Fifteen years of reported incidents were reviewed to provide insight into the effectiveness of an Incident Learning System (ISL). The actual error rate over the 15 years was 1.3 reported errors per 1000 treatment attendances.
Sandie Smith, Andrew Wallis, Odette King, Daniel Moretti, Philip Vial, Jesmin Shafiq, Michael B. Barton, Aitang Xing, Geoff P. Delaney   +8 more
doaj   +1 more source

Actionability classification of variants of unknown significance correlates with functional effect

npj Precision Oncology, 2023
Genomically-informed therapy requires consideration of the functional impact of genomic alterations on protein expression and/or function. However, a substantial number of variants are of unknown significance (VUS).
Amber Johnson, Patrick Kwok-Shing Ng, Michael Kahle, Julia Castillo, Bianca Amador, Yujia Wang, Jia Zeng, Vijaykumar Holla, Thuy Vu, Fei Su, Sun-Hee Kim, Tara Conway, Xianli Jiang, Ken Chen, Kenna R. Mills Shaw, Timothy A. Yap, Jordi Rodon, Gordon B. Mills, Funda Meric-Bernstam   +18 more
doaj   +1 more source

Neutrophil Extracellular Traps in Cancer Therapy Resistance

, 2022
Neutrophils and their products are increasingly recognized to have a key influence on cancer progression and response to therapy. Their involvement has been shown in nearly every aspect of cancer pathophysiology with growing evidence now supporting their
Jonathan J. Cools-Lartigue, Xin Su, Ariane Brassard, Lorenzo E. Ferri, Lixuan Feng, Iqraa Dhoparee-Doomah, Jonathan D. Spicer, Muhammad H. Shahzad   +7 more
core   +1 more source

Role of ultraviolet mutational signature versus tumor mutation burden in predicting response to immunotherapy

Molecular Oncology, 2020
Hydrophobic neoantigens are more immunogenic because they are better presented by the major histocompatibility complex and better recognized by T cells. Tumor cells can evade the immune response by expressing checkpoints such as programmed death ligand 1.
Timothy V. Pham, Amélie Boichard, Aaron Goodman, Paul Riviere, Huwate Yeerna, Pablo Tamayo, Razelle Kurzrock   +6 more
doaj   +1 more source

Role of Interleukin-18 in Thyroid tumorigenesis [PDF]

, 2016
Purpose: Although the significance of Interleukin-18 (IL-18) has been studied in pathogenesis of different cancers including, ovarian, gastric, breast, lung carcinoma and melanoma, its role in thyroid cancer- the most common endocrine malignancy has not ...
Gajjar, Kinjal; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India, Kobawala, Toral; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India, Patel, Girish; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India, Ghosh, Nandita; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India, Trivedi, Trupti; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India   +4 more
core   +1 more source

A TCR-based Chimeric Antigen Receptor

Scientific Reports, 2017
Effector T cells equipped with engineered antigen receptors specific for cancer targets have proven to be very efficient. Two methods have emerged: the Chimeric Antigen Receptors (CARs) and T-cell Receptor (TCR) redirection.
Even Walseng, Hakan Köksal, Ibrahim M. Sektioglu, Anne Fåne, Gjertrud Skorstad, Gunnar Kvalheim, Gustav Gaudernack, Else Marit Inderberg, Sébastien Wälchli   +8 more
doaj   +1 more source

Assessment of a Therapeutic X-ray Radiation Dose Measurement System Based on a Flexible Copper Indium Gallium Selenide Solar Cell

Sensors, 2022
Several detectors have been developed to measure radiation doses during radiotherapy. However, most detectors are not flexible. Consequently, the airgaps between the patient surface and detector could reduce the measurement accuracy.
Dong-Seok Shin, Tae-Ho Kim, Jeong-Eun Rah, Dohyeon Kim, Hye Jeong Yang, Se Byeong Lee, Young Kyung Lim, Jonghwi Jeong, Haksoo Kim, Dongho Shin, Jaeman Son   +10 more
doaj   +1 more source

Treatment planning study comparing proton therapy, RapidArc and intensity modulated radiation therapy for a synchronous bilateral lung cancer case

, 2014
Purpose: The main purpose of this study is to perform a treatment planning study on a synchronous bilateral non-small cell lung cancer case using three treatment modalities: uniform scanning proton therapy, RapidArc, and intensity modulated radiation ...
Zheng, Yuanshui; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Zhao, Li; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Risalvato, Dina; Department of Medical Dosimetry, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA., Vargas, Carlos; Radiation Oncology, Proton Collaborative Group (PCG), Bloomington, Indiana, USA., Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Pokharel, Shyam; Department of Medical Physics, 21st Century Oncology, Fort Myers, Florida, USA., Cersonsky, Nancy; Department of Radiation Oncology, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA.   +6 more
core   +1 more source