Results 31 to 40 of about 15,755,427 (366)
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Protein & Cell, 2020 The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Pranavi Koppula, L. Zhuang, Boyi Gan
semanticscholar +1 more source
Suboptimal Vitamin D levels among adult survivors of childhood cancers [PDF]
, 2016 Purpose: Vitamin D plays an important role in many bodily systems, with increasing evidence suggesting its importance for the prevention of chronic diseases and cancer.
Lisac, Robert; Department of Pediatric Oncology, Roswell Park Cancer Institute, Buffalo, New York +4 more
core +2 more sources
Radiation Oncology, 2019 Background We performed a prospective phase II study to compare acute toxicity among five different hypofractionated schedules using proton therapy. This study was an exploratory analysis to investigate the secondary end-point of biochemical failure-free
Boram Ha +13 more
doaj +1 more source
Cisplatin in cancer therapy: molecular mechanisms of action
European Journal of Pharmacology, 2014 Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against
S. Dasari, P. Tchounwou
semanticscholar +1 more source
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
Signal Transduction and Targeted Therapy, 2023 Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality, underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis, chemoresistance, and the mechanistic backgrounds of
M. Bahar, Hyun Joon Kim, D. Kim
semanticscholar +1 more source
The role of CDK inhibitors in breast cancer therapy [PDF]
, 2016 Cyclin D1 and cyclin-dependent protein kinases CDK4/6 are part of RB-pathway which plays a very important role in the regulation of cell cycle progression and cell death.
Huszno, Joanna; Clinical and Experimental Oncology Department, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
core +7 more sources
Targeting cancer stem cell pathways for cancer therapy
Signal Transduction and Targeted Therapy, 2020 Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor ...
Liqun Yang +10 more
semanticscholar +1 more source
Cancer research and therapy: Where are we today? [PDF]
, 2014 Till date scientists are struggling to understand the complete mechanism of carcinogenesis. In future, the real time detection of cancer may help scientists to identify some of the complicated biological mechanisms.
Sawant, Sampada; C.U. Shah College of Pharmacy, SNDT Women’s University, Juhu, Santacruz (West), Mumbai, India +1 more
core +1 more source
BMC Urology, 2020 Background In definitive radiation therapy for prostate cancer, the SpaceOAR® System, a hydrogel spacer, is widely used to decrease the irradiated dose and toxicity of rectum.
Tairo Kashihara +20 more
doaj +1 more source
Nanomedicine in cancer therapy
Signal Transduction and Targeted Therapy, 2023 Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise
Dahua Fan +5 more
semanticscholar +1 more source