Results 11 to 20 of about 15,755,427 (366)
Macrophages as tools and targets in cancer therapy
Nature reviews. Drug discovery, 2022 Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix remodelling, cancer cell proliferation, metastasis and immunosuppression, as well as in ...
A. Mantovani +3 more
semanticscholar +1 more source
Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Signal Transduction and Targeted Therapy, 2022 Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to ...
Zhiwen Fu +4 more
semanticscholar +1 more source
Acta Neuropathologica Communications, 2021 An amendment to this paper has been published and can be accessed via the original article.
Xiaolei Lian +6 more
doaj +1 more source
Design considerations of an IL13Rα2 antibody–drug conjugate for diffuse intrinsic pontine glioma
Acta Neuropathologica Communications, 2021 Diffuse intrinsic pontine glioma (DIPG), a rare pediatric brain tumor, afflicts approximately 350 new patients each year in the United States. DIPG is noted for its lethality, as fewer than 1% of patients survive to five years.
Xiaolei Lian +6 more
doaj +1 more source
Targeting PI3K/Akt signal transduction for cancer therapy
Signal Transduction and Targeted Therapy, 2021 The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence and progression of tumors.
Yan He +6 more
semanticscholar +1 more source
Ferroptosis in cancer therapy: a novel approach to reversing drug resistance
Molecular Cancer, 2022 Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a pivotal role in tumor suppression, thus providing new opportunities for cancer ...
Chen Zhang +4 more
semanticscholar +1 more source
Molecular Cancer, 2023 Background Chimeric Antigen Receptor (CAR) T cells are now standard of care (SOC) for some patients with B cell and plasma cell malignancies and could disrupt the therapeutic landscape of solid tumors.
Hyatt Balke-Want +16 more
doaj +1 more source
Preclinical therapeutics ex ovo quail eggs as a biomimetic automation-ready xenograft platform
Scientific Reports, 2021 Preclinical cancer research ranges from in vitro studies that are inexpensive and not necessarily reflective of the tumor microenvironment to mouse studies that are better models but prohibitively expensive at scale. Chorioallantoic membrane (CAM) assays
Samuel V. Rasmussen +6 more
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Neoantigens: promising targets for cancer therapy
Signal Transduction and Targeted Therapy, 2023 Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and antibody-based therapies, especially for solid tumors.
N-N Xie +5 more
semanticscholar +1 more source
Fluorescent imaging for cancer therapy and cancer gene therapy [PDF]
Molecular Therapy Oncolytics, 2021 The translation of laboratory science into effective clinical cancer therapy is gaining momentum more rapidly than any other time in history. Understanding cancer cell-surface receptors, cancer cell growth, and cancer metabolic pathways has led to many promising molecular-targeted therapies and cancer gene therapies.
Yanghee Woo +4 more
openaire +3 more sources