Results 1 to 10 of about 5,441,106 (361)

Anti-tumor activity of a T-helper 1 multiantigen vaccine in a murine model of prostate cancer [PDF]

Scientific Reports, 2022
Prostate cancer is one of the few malignancies that includes vaccination as a treatment modality. Elements of an effective cancer vaccine should include the ability to elicit a Type I T-cell response and target multiple antigenic proteins expressed early
Denise L. Cecil, Benjamin Curtis, Ekram Gad, Michael Gormley, Andrew E. Timms, Lauren Corulli, Rinke Bos, Rajendra N. Damle, Manuel A. Sepulveda, Mary L. Disis   +9 more
doaj   +2 more sources

Personalized cancer vaccine design using AI-powered technologies. [PDF]

Front Immunol
Immunotherapy has ushered in a new era of cancer treatment, yet cancer remains a leading cause of global mortality. Among various therapeutic strategies, cancer vaccines have shown promise by activating the immune system to specifically target cancer ...
Kumar A, Dixit S, Srinivasan K, M D, Vincent PMDR.   +4 more
europepmc   +2 more sources

Cancer Vaccine Therapeutics: Limitations and Effectiveness—A Literature Review

Cells, 2023
In recent years, there has been a surge of interest in tumor microenvironment-associated cancer vaccine therapies. These innovative treatments aim to activate and enhance the body’s natural immune response against cancer cells by utilizing specific ...
M. Kaczmarek, Justyna Poznańska, Filip Fechner, Natasza Michalska, Sara Paszkowska, Adrianna Napierała, Andrzej Mackiewicz   +6 more
semanticscholar   +1 more source

Cross-protective antibodies against common endemic respiratory viruses

Nature Communications, 2023
Respiratory syncytial virus (RSV), human metapneumovirus (HMPV), and human parainfluenza virus types one (HPIV1) and three (HPIV3) can cause severe disease and death in immunocompromised patients, the elderly, and those with underlying lung disease.
Madelyn Cabán, Justas V. Rodarte, Madeleine Bibby, Matthew D. Gray, Justin J. Taylor, Marie Pancera, Jim Boonyaratanakornkit   +6 more
doaj   +1 more source

Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Current messenger RNA (mRNA) vaccines in the clinic were reported to induce side effects in the liver, such as reversible hepatic damages and T cell–dominant immune-mediated hepatitis, which might be caused by the undesired expression of ...
Jinjin Chen, Zhongfeng Ye, Changfeng Huang, Min Qiu, Donghui Song, Yamin Li, Qiaobing Xu   +6 more
semanticscholar   +1 more source

Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

npj Vaccines, 2021
We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured
Kelly E. Seaton, Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, Mary A. Allen, Xiaoying Shen, Sheetal Sawant, Nicole L. Yates, Paul Spearman, Gavin Churchyard, Paul A. Goepfert, Janine Maenza, Glenda Gray, Giuseppe Pantaleo, Laura Polakowski, Harriet L. Robinson, Shannon Grant, April K. Randhawa, Ying Huang, Cecilia Morgan, Nicole Grunenberg, Shelly Karuna, Peter B. Gilbert, M. Juliana McElrath, Yunda Huang, Georgia D. Tomaras, NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams   +29 more
doaj   +1 more source

Biomimetic and bioinspired nano‐platforms for cancer vaccine development

Exploration, 2023
The advent of immunotherapy has revolutionized the treating modalities of cancer. Cancer vaccine, aiming to harness the host immune system to induce a tumor‐specific killing effect, holds great promises for its broad patient coverage, high safety, and ...
Chenchao Feng, Peng Tan, Guangjun Nie, Motao Zhu   +3 more
semanticscholar   +1 more source

Engineered Probiotic‐Based Personalized Cancer Vaccine Potentiates Antitumor Immunity through Initiating Trained Immunity

Advancement of science, 2023
Cancer vaccines hold great potential for clinical cancer treatment by eliciting T cell‐mediated immunity. However, the limited numbers of antigen‐presenting cells (APCs) at the injection sites, the insufficient tumor antigen phagocytosis by APCs, and the
Zhaoxia Chen, Tuying Yong, Zhaohan Wei, Xiaoqiong Zhang, Xin Li, J. Qin, Jianye Li, Jun Hu, Xiangliang Yang, L. Gan   +9 more
semanticscholar   +1 more source

Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

Nature Protocols, 2022
Here we present a protocol for the construction and use of two types of nanocarrier based on bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor regression through triggering the specific T-cell responses against tumor ...
Xiao Zhao, Ruifang Zhao, Guangjun Nie
semanticscholar   +1 more source

Materials engineering strategies for cancer vaccine adjuvant development.

Chemical Society Reviews, 2023
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy. Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the immune response.
Xuanbo Zhang, Bowei Yang, Qianqian Ni, Xiaoyuan Chen   +3 more
semanticscholar   +1 more source