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Cancer vaccines

Cancer Cell, 2022
Given the renewed interest in vaccine development sparked by the COVID-19 pandemic, we are revisiting the current state of vaccine development for cancer prevention and treatment. Experts discuss different vaccine types, their antigens and modes of action, and where we stand on their clinical development, plus the challenges we need to overcome for ...
Schiller, John T, Lowy, Douglas R, Frazer, Ian H, Finn, Olivera J, Vilar, Eduardo, Lyerly, H Kim, Gnjatic, Sacha, Zaidi, Neeha, Ott, Patrick A, Balachandran, Vinod P, Dietrich, Pierre-Yves, Migliorini, Denis, Vonderheide, Robert H, Domchek, Susan M   +13 more
openaire   +2 more sources

Cross-protective antibodies against common endemic respiratory viruses

Nature Communications, 2023
Respiratory syncytial virus (RSV), human metapneumovirus (HMPV), and human parainfluenza virus types one (HPIV1) and three (HPIV3) can cause severe disease and death in immunocompromised patients, the elderly, and those with underlying lung disease.
Madelyn Cabán, Justas V. Rodarte, Madeleine Bibby, Matthew D. Gray, Justin J. Taylor, Marie Pancera, Jim Boonyaratanakornkit   +6 more
doaj   +1 more source

Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

npj Vaccines, 2021
We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured
Kelly E. Seaton, Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, Mary A. Allen, Xiaoying Shen, Sheetal Sawant, Nicole L. Yates, Paul Spearman, Gavin Churchyard, Paul A. Goepfert, Janine Maenza, Glenda Gray, Giuseppe Pantaleo, Laura Polakowski, Harriet L. Robinson, Shannon Grant, April K. Randhawa, Ying Huang, Cecilia Morgan, Nicole Grunenberg, Shelly Karuna, Peter B. Gilbert, M. Juliana McElrath, Yunda Huang, Georgia D. Tomaras, NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams   +29 more
doaj   +1 more source

Personalized cancer vaccine design using AI-powered technologies [PDF]

Front Immunol
Anant Kumar, Shriniket Dixit, Kathiravan Srinivasan, M. Dinakaran, P. M. Durai Raj Vincent   +4 more
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Anti-tumor activity of a T-helper 1 multiantigen vaccine in a murine model of prostate cancer

Scientific Reports, 2022
Prostate cancer is one of the few malignancies that includes vaccination as a treatment modality. Elements of an effective cancer vaccine should include the ability to elicit a Type I T-cell response and target multiple antigenic proteins expressed early
Denise L. Cecil, Benjamin Curtis, Ekram Gad, Michael Gormley, Andrew E. Timms, Lauren Corulli, Rinke Bos, Rajendra N. Damle, Manuel A. Sepulveda, Mary L. Disis   +9 more
doaj   +1 more source

EXTH-40. IMMUNOPHENOTYPING OF RWTC-MBTA AUTOLOGOUS CANCER VACCINE IN PRECLINICAL GLIOBLASTOMA MODELS [PDF]

Neuro Oncol
Herui Wang, Juan Ye, Rogelio Medina, Yaping Zhang, Samik Chakraborty, Ondřej Uher, Katerina Hadrava Vanova, Jan Ženka, Karel Pacák, Zhengping Zhuang   +9 more
openalex   +2 more sources

Could widespread use of antiviral treatment curb the COVID-19 pandemic? A modeling study

BMC Infectious Diseases, 2022
Background Despite the development of safe and effective vaccines, effective treatments for COVID-19 disease are still urgently needed. Several antiviral drugs have shown to be effective in reducing progression of COVID-19 disease. Methods In the present
Laura Matrajt, Elizabeth R. Brown, Myron S. Cohen, Dobromir Dimitrov, Holly Janes   +4 more
doaj   +1 more source

Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients

npj Breast Cancer, 2021
B cell responses to tumor antigens occur early in breast tumors and may identify immunogenic drivers of tumorigenesis. Sixty-two candidate antigens were identified prior to palpable tumor development in TgMMTV-neu and C3(1)Tag transgenic mouse mammary ...
Sasha E. Stanton, Ekram Gad, Erik Ramos, Lauren Corulli, James Annis, Jennifer Childs, Hiroyuki Katayama, Samir Hanash, Jeffrey Marks, Mary L. Disis   +9 more
doaj   +1 more source

Optimizing vaccine allocation for COVID-19 vaccines shows the potential role of single-dose vaccination

Nature Communications, 2021
Most COVID-19 vaccines require two doses but a single dose provides partial protection, so it is unclear how best to prioritize vaccine distribution in the context of limited supply.
Laura Matrajt, Julia Eaton, Tiffany Leung, Dobromir Dimitrov, Joshua T. Schiffer, David A. Swan, Holly Janes   +6 more
doaj   +1 more source

Cancer Vaccines [PDF]

Primary Care: Clinics in Office Practice, 2011
The term cancer vaccines encompasses 2 different types of vaccines. Prophylactic vaccines block infection by viruses that can alter host DNA and result in cancer. The hepatitis B vaccine and the human papillomavirus vaccines are examples of prophylactic vaccines that can prevent cancer from developing.
openaire   +4 more sources