What cleaves? Is proteasomal cleavage prediction reaching a ceiling? [PDF]
arXiv, 2022 Epitope vaccines are a promising direction to enable precision treatment for cancer, autoimmune diseases, and allergies. Effectively designing such vaccines requires accurate prediction of proteasomal cleavage in order to ensure that the epitopes in the vaccine are presented to T cells by the major histocompatibility complex (MHC).
arxiv
Human papillomavirus vaccination coverage in Luxembourg : implications of lowering and restricting target age groups [PDF]
, 2018 Background: In Luxembourg, a national Human Papillomavirus (HPV) vaccination programme was introduced in 2008, targeting 12-17 year old girls offering a choice of bivalent or quadrivalent vaccine free of charge.
Arbyn, Marc +3 more
core +2 more sources
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Role of the Dental Community in HPV Vaccination Promotion [PDF]
, 2018 Introduction. With increasing awareness that human papillomavirus (HPV) can cause oropharyngeal cancer (OPC), dental providers may play an important role in promoting HPV vaccination and preventing cancer. Our goal was to assess knowledge and current HPV
Arnell, Thomas Luke +8 more
core +1 more source
Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation. [PDF]
, 2012 In pediatric patients with malignancy and those receiving hematopoietic stem cell transplants, bacterial and fungal infections have been the focus of fever and neutropenia episodes for decades.
Alexander, Sarah +5 more
core +1 more source
Advanced Healthcare Materials, EarlyView.The new generation nanobomb, termed the stealth nanobomb, is fabricated through self‐assembly using a polymeric carbon monoxide carrier (PLGA(CO)), small molecule near‐infrared‐active agents (2TT‐OC46B), and phospholipid polyethylene glycol (DSPE‐mPEG2000). The stealth nanobomb can circulate in the bloodstream and specifically target pancreatic cancer,
Gongcheng Ma +10 more
wiley +1 more source
Nature CommunicationsTo prevent sexually-acquired HIV-1 infection by immunoprophylaxis, effective concentrations of broadly neutralizing antibodies are likely needed at mucosal sites of exposure.
Maria P. Lemos +20 more
doaj +1 more source
Random Measures, ANOVA Models and Quantifying Uncertainty in Randomized Controlled Trials [PDF]
arXiv, 2023 This short paper introduces a novel approach to global sensitivity analysis, grounded in the variance-covariance structure of random variables derived from random measures. The proposed methodology facilitates the application of information-theoretic rules for uncertainty quantification, offering several advantages.
arxiv
The effects of perceived risk and responsibility on the acceptance of a Human Papillomavirus vaccine by college men [PDF]
, 2009 In the summer of 2006 the Food and Drug Administration approved a new vaccine to prevent four types of the Human Papillomavirus believed to cause the majority of genital warts and cervical cancer in women.
Mitiguy, Angela Marie
core +1 more source
Evaluation of the burden of HPV-related hospitalizations as a useful tool to increase awareness: 2007–2017 data from the sicilian hospital discharge records [PDF]
, 2020 In light of the implementation of human papillomavirus (HPV) prevention strategies, epidemiological studies in different geographical areas are required in order to assess the impact of HPV-related diseases.
Amato L. +10 more
core +1 more source