Results 171 to 180 of about 286,222 (357)

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Cervical cancer chemoprevention, vaccines, and surrogate endpoint biomarkers [PDF]

, 2003
Michele Follen, Frank L. Meyskens, Ronald D. Alvarez, Joan L. Walker, Maria C. Bell, Karen A. Storthz, K. Jagannadha Sastry, Krishnendu Roy, Rebecca Richards‐Kortum, Terri L. Cornelison   +9 more
openalex   +1 more source

FIGURE 4 from Immunologic Signatures of Peripheral Blood T Cells Reveal the Outcome of p53MVA Vaccine and Pembrolizumab Treatment in Patients with Advanced Ovarian Cancer

, 2023
Ferdynand J. Kos, Paul Frankel, Mihaela Cristea, Melissa Eng, Raechelle Tinsley, Shannon Dempsey, Nora Ruel, Daphne Stewart, Thanh H. Dellinger, Don J. Diamond   +9 more
openalex   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Can a single dose of human papillomavirus (HPV) vaccine prevent cervical cancer? Early findings from an Indian study

, 2018
Rengaswamy Sankaranarayanan, Smita Joshi, Richard Muwonge, Pulikottil Okkuru Esmy, Partha Basu, Priya R. Prabhu, Neerja Bhatla, Bhagwan M. Nene, Janmesh Shaw, Usha Rani Poli, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Massimo Tommasino, Michael Pawlita, Tarik Gheit, Tim Waterboer, Peter Sehr, Madhavan Radhakrishna Pillai   +18 more
openalex   +1 more source

A vaccine to prevent cervical cancer: academic and industrial collaboration and a Lasker award [PDF]

, 2017
Edward M. Scolnick
openalex   +1 more source

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source

Endoglin (CD105) is a target for an oral DNA vaccine against breast cancer

, 2006
Sung‐Hyung Lee, Noriko Mizutani, Masato Mizutani, Yunping Luo, He Zhou, Charles D. Kaplan, Sung Woo Kim, Rong Xiang, Ralph A. Reisfeld   +8 more
openalex   +2 more sources

Protective Cancer Vaccine Using Genetically Modified Hematopoietic Stem Cells [PDF]

, 2018
Xiaofang Xiong, Jugal Kishor Das, Jianyong Song, Bing Ni, Xingcong Ren, Jin-Ming Yang, Jianxun Song, Jianxun Song, Jianxun Song   +8 more
openalex   +1 more source

Polymer Nanoparticle‐Mediated Delivery of Oxidized Tumor Lysate‐Based Cancer Vaccines [PDF]

, 2021
Cristiana Berti, Michele Graciotti, Alice Boarino, Chakradhar Yakkala, Lana E. Kandalaft, Harm‐Anton Klok   +5 more
openalex   +1 more source