Results 251 to 260 of about 163,730 (308)

Eliciting antitumor immunity via therapeutic cancer vaccines. [PDF]

Cell Mol Immunol
Peng K, Zhao X, Fu YX, Liang Y.
europepmc   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Therapeutic Cancer Vaccines in Colorectal Cancer: Platforms, Mechanisms, and Combinations. [PDF]

Cancers (Basel)
Gallio C, Esposito L, Passardi A.
europepmc   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

A systematic review of the efficacy of cancer vaccines in advanced breast cancer. [PDF]

Breast Cancer
Charalampopoulou A, Filippatos C, Malandrakis P, Zagouri F, Gavriatopoulou M, Ntanasis-Stathopoulos I.   +5 more
europepmc   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

A Comprehensive Review of Nanoadjuvants in Cancer Vaccines and Their Immunomodulatory Role and Clinical Applications. [PDF]

Arch Razi Inst
Mahan H, Neda M, Elahe DN, Nilufar HS, Mahsa F, Farjad Z, Amirhossein DD, Shiva D.   +7 more
europepmc   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Strategic Advances in Targeted Delivery Carriers for Therapeutic Cancer Vaccines. [PDF]

Int J Mol Sci
Wu J, Liang J, Zhang Y, Dong C, Tan D, Wang H, Zheng Y, He Q.   +7 more
europepmc   +1 more source

Engineering pyroptotic vesicles as personalized cancer vaccines. [PDF]

Nat Nanotechnol
Li Z, Wang Y, Mo F, Wolter T, Hong R, Barrett A, Richmond N, Liu F, Chen Y, Yang X, Dempsey L, Hu Q.   +11 more
europepmc   +1 more source