Results 321 to 330 of about 269,977 (355)

Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy. [PDF]

iScience
Li Q, Yan Y, Wang C, Dong Z, Hao Y, Chen M, Liu Z, Feng L.   +7 more
europepmc   +1 more source

Oncology Dose Optimization: Tailored Approaches to Different Molecular Classes

Clinical Pharmacology &Therapeutics, EarlyView.
Oncology dose optimization during the era of chemotherapy focused on identifying the maximum tolerated dose (MTD) for registrational trials, often resulting in significant toxicity. The advent of molecular targeted drugs and immunotherapies offers the potential to achieve similar efficacy with lower doses and fewer side effects, as maximal efficacy is ...
Jiawen Zhu, Amy Schroeder, Sabine Frank, Christophe Boetsch, Candice Jamois, Nastya Kassir, Koorosh Korfi, Elizabeth Punnoose, Anjali Vaze, Peter Trask, Pritti Gosai, Jane Fridlyand, Chunze Li   +12 more
wiley   +1 more source

Nucleic acid cancer vaccines targeting tumor related angiogenesis. Could mRNA vaccines constitute a game changer? [PDF]

Front Immunol
Tadic S, Martínez A.
europepmc   +1 more source

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

ESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher, Roger Hodkinson, William Makis, Peter A. McCullough   +3 more
wiley   +1 more source

How to handle polypharmacy in heart failure. A clinical consensus statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
Linking guideline‐directed medical therapy (GDMT) implementation and appropriate polypharmacy management in heart failure (HF). Polypharmacy can represent a barrier to the proper implementation of life‐prolonging GDMT for HF. A reasonable balance between the optimization of GDMT and avoiding inappropriate polypharmacy is mandatory in the contemporary ...
Davide Stolfo, Massimo Iacoviello, Ovidiu Chioncel, Markus S. Anker, Antoni Bayes‐Genis, Frieder Braunschweig, Antonio Cannata, Seif El Hadidi, Gerasimos Filippatos, Pardeep Jhund, Alexandre Mebazaa, Brenda Moura, Massimo Piepoli, Robin Ray, Arsen D. Ristic, Petar Seferovic, Maggie Simpson, Hadi Skouri, Carlo Gabriele Tocchetti, Sophie Van Linthout, Cristiana Vitale, Maurizio Volterrani, Kalliopi Keramida, Sven Wassmann, Basil S. Lewis, Marco Metra, Giuseppe M.C. Rosano, Gianluigi Savarese   +27 more
wiley   +1 more source

Benzochalcogenodiazoles, synthesis and applications in medicinal chemistry and photomedicine.

European Journal of Organic Chemistry, Accepted Article.
Benzochalcogenodiazoles BXDs (BOD: benzoxadiazole, BTD: benzothiadiazole, or BSD: benzoselenadiazole) are aromatic bicyclic compounds, containing chalcogen atoms, with applications ranging from material to medicinal chemistry. The recent developments in their preparation and functionalization are taking advantage of new methodologies such as C‐H ...
Jean-Elie Zheng, Xavier Franck, Thibault Gallavardin   +2 more
wiley   +1 more source

Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines. [PDF]

Mol Ther Oncol
Amhis N, Carignan J, Tai LH.
europepmc   +1 more source

Synthesis of Rhamnose‐Modified Lewis‐X‐Containing Saponins

European Journal of Organic Chemistry, Accepted Article.
We report the synthesis of betulinic acid and echinocystic acid saponins featuring an unnatural analogue of the Lewis‐X trisaccharide, in which the l‐fucose residue is replaced by l‐rhamnose. These triterpenoid saponins were designed as negative controls for dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN ...
Oscar Javier Gamboa Marin, Nitish Verma, Maude Cloutier, Charles Gauthier   +3 more
wiley   +1 more source

Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy. [PDF]

Cell Rep
Keshari S, Shavkunov AS, Miao Q, Saha A, Minowa T, Molgora M, Williams CD, Chaib M, Highsmith AM, Pineda JE, Alekseev S, Alspach E, Hu KH, Colonna M, Pauken KE, Chen K, Gubin MM.   +16 more
europepmc   +1 more source

Current status and future of cancer vaccines: A bibliographic study. [PDF]

Heliyon
Yu R, Zhao F, Xu Z, Zhang G, Du B, Shu Q.   +5 more
europepmc   +1 more source