Results 51 to 60 of about 88,514 (261)
Digitally controlled pulse-level discriminator operates over wide voltage range [PDF]
, 1966 Low power drain discriminator circuit generates an output pulse when an input pulse exceeds a discrete digitally controlled threshold voltage. The discriminator operates over a wide linear or nonlinear range of threshold levels. It uses several amplifier
Cancro, C. A.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Switching circuits with fast response and low power drain [PDF]
, 1970 New logic circuits have response times no longer than 10 nanoseconds and drain only milliwatts of power. The family includes AND and NAND gates and forms the basis of all logic functions.
Cancro, C. A.
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Obstipação induzida pelos opióides em doentes oncológicos adultos
Onco.News, 2017 Os opióides são o gold-standard para o tratamento da dor oncológica, mas alguns dos seus efeitos adversos podem comprometer o seu potencial terapêutico, como é o caso da obstipação.
Daniela Dias +5 more
doaj +1 more source
Synchronized pulse generator needs no external power [PDF]
, 1965 Simple circuit with high input and low output impedance generates a fast rise-time pulse synchronized with an input pulse of slower rise and fall times.
Cancro, C. A., Janniche, P. J., Jr.
core +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
COMPLETE RESPONSE OF CUTANEOUS METASTASIS IN A MELANOMA PATIENT TREATED WITH IPILIMUMAB. [PDF]
Euromediterranean Biomedical Journal, 2012 We present the case of a 58 year old woman, who achieved complete response for her cutaneous melanoma metastasis after treatment with ipilimumab at 3 mg/Kg.
Francesco Spagnolo +3 more
doaj +1 more source
Passive synchronized spike generator with high input impedance and low output impedance and capacitor power supply Patent [PDF]
, 1968 Pulse generator for synchronizing or resetting electronic signals without requiring separate external ...
Cancro, C. A., Janniche, P. J., Jr.
core +1 more source
OCORRÊNCIA DO CANCRO DE TRONCO EM ÁRVORES DE ACOMPANHAMENTO VIÁRIO NA CIDADE DE MARINGÁ, PARANÁ
Revista da Sociedade Brasileira de Arborização Urbana, 2019 O presente trabalho foi realizado na Cidade de Maringá, Paraná, em duas áreas distintas - Zona 1 e Zona 2. A Zona 1 representa a área mais central da cidade, caracterizada por intenso movimento de pessoas e automóveis, enquanto a Zona 2 caracteriza-se ...
B. Angelis +2 more
semanticscholar +1 more source