Results 101 to 110 of about 3,878,610 (315)

Detection of Polymorphisms in BMP15 and GDF9 Genes and Their Associations with Reproductive Traits in Black Bengal Goat of Bangladesh

Tropical Animal Science Journal
The Bone Morphogenetic Protein 15 (BMP15) and Growth Differentiation Factor 9 (GDF9) genes play important roles in follicular development, ovulation rate, and litter size in goats.
M. A. Mou, M. F. A. Hridoy, N. H. Desha, S. Ahmed, M. S. A. Bhuiyan   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Metabolite-based genome-wide association analysis reveals genetic loci and candidate genes affecting breast muscle metabolites in Sansui ducks

Poultry Science
Duck meat is highly appreciated for its unique flavor and rich nutritional value, and metabolites have become important phenotypic indicators of meat quality.
Yulong Feng, Mengru Xu, Xintong Yu, Zhao Yang, Jingjing Qi, Yang Xi, Shihao Guo, Xu Han, Meijuan Li, Yuxi Lu, Guotao Dai, Chengcheng Tian, Yu Zhao, Anqi Huang, Liang Li, Hehe Liu   +15 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Knowledge-based gene expression classification via matrix factorization [PDF]

, 2008
Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze ...
Schachtner, R., Lang, E. W., Tomé, A. M., Gómez Vilda, P., Vilda, P.G., Theis, Fabian J., Theis, F. J., Knollmüller, P., Schmitz, G., Lang, Elmar, Lang, E.W., Lutter, D., Stetter, M., Theis, F.J., Tomé, A.M.   +14 more
core   +2 more sources

Identification of Dwarfing Candidate Genes in Brassica napus L. LSW2018 through BSA–Seq and Genetic Mapping

Plants
Plant height, as a crucial component of plant architecture, exerts a significant influence on rapeseed (Brassica napus L.) lodging resistance, photosynthetic efficiency, yield, and mechanized harvest level.
Sha Huang, Fang Wang, Yang Li, Zhuanzhuan Wang, Ruimao Zhang, Jijun Li, Chao Li   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Mapping and candidate-gene screening of the novel Turnip mosaic virus resistance gene retr02 in Chinese cabbage (Brassica rapa L.) [PDF]

, 2013
The extreme resistance to Turnip mosaic virus observed in the Chinese cabbage (Brassica rapa) line, BP8407, is monogenic and recessive. Bulked segregant analysis was carried out to identify simple sequence repeat and Indel markers linked to this ...
Zhang, Hui, Fei Li, Walsh, John A., Xiaowu Wang, Wu, Jian, Sun, Rifei, Rifei Sun, Qian, Wei, Wang, Xiaowu, Shifan Zhang, John A. Walsh, Shujiang Zhang, Jian Wu, Zhang, Shujiang, Li, Fei, Wei Qian, Zhang, Shifan, Hui Zhang   +17 more
core   +1 more source