Results 81 to 90 of about 3,878,610 (315)

Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study

BMC Medical Genetics, 2017
Background Essential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular endothelium and is produced in endothelial cells by the enzyme endothelial nitric ...
Sahar Gamil, Jeanette Erdmann, Ihab B. Abdalrahman, Abdelrahim O. Mohamed   +3 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Transcriptomic characterization of two major Fusarium resistance quantitative trait loci (QTLs), Fhb1 and Qfhs.ifa-5A, identifies novel candidate genes [PDF]

, 2013
Fusarium head blight, caused by Fusarium graminearum, is a devastating disease of wheat. We developed near-isogenic lines (NILs) differing in the two strongest known F.
Wiesenberger, Gerlinde, Lemmens, Marc, Buerstmayr, Hermann, Schweiger, W. (Wolfgang), Steiner, B. (Barbara), Jia, Haiyan, Siegwart, Gerald, Berthiller, Franz, Adam, G. (Gerhard), Kreil, David, Ametz, Christian, Muehlbauer, Gary J.   +11 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Polymorphisms of the APCDD1 gene and their association with body measurements and reproductive traits in goats

Huanan Nongye Daxue xuebao
ObjectiveAdenomatosis polyposis coli down-regulated 1 (APCDD1) is a conserved single-pass transmembrane protein that negatively regulates WNT signaling and is closely associated with cell proliferation and differentiation.
Zhiyi LEI, De’an ZHANG, Kaihao CHEN, Jie LIU, Guangbin LIU, Dewu LIU, Yaokun LI, Ming DENG   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Three regulatory elements upstream of LMO4 are strongly associated with intermittent fertilization intensity in Chicken

Poultry Science
Intermittent fertilization intensity (IFI) is closely related to higher fertilization in chicken hens. Recent studies have identified genes influencing sperm-oocyte interactions and immune regulation that impact the fertilization process in chickens ...
Lei Wang, Weijian Fan, Xiuping Wang, Yangming Pan, Xing Hong, Mingze Li, ShiJun Li   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Grass cell wall feruloylation: distribution of bound ferulate and candidate gene expression in Brachypodium distachyon [PDF]

, 2013
The cell walls of grasses such as wheat, maize, rice and sugar cane, contain large amounts of ferulate that is ester-linked to the cell wall polysaccharide glucuronoarabinoxylan (GAX).
Peter Robert Shewry, Jackie Freeman, Pellny, T. K., Freeman, J., Hugo Bruno Correa Molinari, Jackie eFreeman, Shewry, P. R., Rowan A. C. Mitchell, Hugo B. C. Molinari, Rowan Andrew Craig Mitchell, Till Konstantin Pellny, Till K. Pellny, Molinari, H. B. C., Peter R. Shewry, Mitchell, R. A. C.   +14 more
core   +1 more source