Results 71 to 80 of about 3,878,610 (315)

[Genes and kidney disease. Candidate genes].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2002
80
Rodríguez Pérez, J. C., Rodríguez Esparragón, F., Torres, M. J., Hernández Perera, O.   +3 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Evaluation of the CTSL2 gene as a candidate gene for alopecia X in Pomeranians and Keeshonden

, 2007
Alopecia X is a noninflammatory, progressive, bilateral symmetric alopecia in dogs. The disease is mainly found in Nordic breeds. The breed predisposition and a strong familial accumulation suggest a hereditary background.
Mausberg, Eva-Maria, Dolf, Gaudenz, Rüfenacht, Silvia, Welle, Monika Maria, Drögemüller, Cord, Leeb, Tosso   +5 more
core   +1 more source

Dissecting the organ specificity of insecticide resistance candidate genes in Anopheles gambiae : known and novel candidate genes [PDF]

, 2014
Background The elevated expression of enzymes with insecticide metabolism activity can lead to high levels of insecticide resistance in the malaria vector, Anopheles gambiae.
Simon C Wagstaff, Pignatelli, Patricia, Jonathan D Moore, Wagstaff, Simon C., Moore, Jonathan D., Ingham, Victoria A., Jones, Christopher M., Ingham, Victoria; id_orcid, Ranson, Hilary; id_orcid, Patricia Pignatelli, Jones, Chris, Victoria A Ingham, Vontas, John, Balabanidou, Vasileia, Christopher M Jones, Ranson, Hilary, Hilary Ranson, John Vontas, Vasileia Balabanidou, Wagstaff, Simon   +19 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Identification of SNPs in TG and EDG1 genes and their relationships with carcass traits in Korean cattle (Hanwoo) [PDF]

, 2012
Thyroglobulin (TG) gene was known to be regulated fat cell growth and differentiation and the endothelial differentiation sphingolipid G-protein-coupled receptor 1 (EDG1) gene involves blood vessel formation and known to be affecting carcass traits ...
Cahyadi, Muhammad, Lee, Seung Hwan, Ryoo, Seung Heui, Lee, Jun Heon, Maharani, Dyah   +4 more
core  

Multiregional Gene Expression Profiling Identifies MRPS6 as a Possible Candidate Gene for Parkinson’s Disease

, 2006
Combining large-scale gene expression approaches and bioinformatics may provide insights into the molecular variability of biological processes underlying neurodegeneration.
Qin, Yujing, FFrench-Mullen, Jarlath, McCorquodale, Donald, Mash, Deborah C, Pablo, John, Papapetropoulos, Spiridon   +5 more
core   +1 more source

Identification and functional characterisation of a novel dopamine beta hydroxylase gene variant associated with ADHD [PDF]

, 2015
Dysregulation in neurotransmitter signalling has been implicated in the aetiology of ADHD. Polymorphisms of the gene encoding dopamine beta hydroxylase (DBH), a key player in catecholamine signalling, have been shown to be associated with increased risk ...
Tong, Janette, Matthews, Natasha, Vance, Alasdair, Heussler, H, Cummins, Tarrant, Kent, L, Cummins, Tarrant D. R., Tarrant D.R. Cummins (567322), Cummins, TDR, Hawi, Z, McKinley, LA, Hawi, Ziarih, Matthews, N, Michael Gill (195307), Alasdair Vance (402134), Ziarih Hawi (402129), Bellgrove, MA, Tong, J, Vance, A, Johnson, Beth, Kent, Lindsey, Helen Heussler (833687), Mark A. Bellgrove (197726), Gill, Michael, Janette Tong (189221), Natasha Matthews (402130), Lindsey Kent (402135), Heussler, Helen, McKinley, Leigh-Anne, Beth Johnson (833686), Belgrove, Mark, Leigh-Anne McKinley (833685), Bellgrove, Mark A., Johnson, B, Gill, M   +34 more
core   +1 more source

Orexin/Hypocretin Type 2 Receptor (HCRTR2) Gene as a Candidate Gene in Sertraline-Associated Insomnia in Depressed Patients

Neuropsychiatric Disease and Treatment, 2020
Negar Firouzabadi,1,2 Niloofar Navabzadeh,1 Ebrahim Moghimi-Sarani,3 Maral Haghnegahdar1 1Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; 2Pharmaceutical Sciences Research Center, Shiraz
Firouzabadi N, Navabzadeh N, Moghimi-Sarani E, Haghnegahdar M   +3 more
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