Results 61 to 70 of about 3,878,610 (315)

Is Mortalin a Candidate Gene for T1DM ?

Autoimmunity, 2004
Mortalin has been found to be up-regulated by 2D-protein gel analysis in isolated rodent islets exposed to cytokines. In islets from two rat strains with different sensitivity to the toxic effects of cytokines we observed a significant difference in IL-1beta mediated mortalin expression.
Jesper, Johannesen, Angeles, Pie, Allan Ertmann, Karlsen, Zenia Marian, Larsen, Allan, Jensen, Henrik, Vissing, Ole Peter, Kristiansen, Flemming, Pociot, Jørn, Nerup   +8 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Identification of the gene for Nance-Horan syndrome (NHS) [PDF]

, 2004
Objective: To identify the gene or genes responsible for these diseases. Methods: Families with NHS were ascertained. The refined locus for CXN was used to focus the search for candidate genes, which were screened by polymerase chain reaction and ...
Brooks, S.P., Moore, A.T., Lehmann, O.J., Hardcastle, A.J., Poopalasundaram, S., Ebenezer, N.D.   +5 more
core  

A study of association between genetic markers in candidate genes and reproductive traits in one generation of a commercial broiler breeder hen population [PDF]

, 2004
Markers of alleles for three physiological candidate genes for reproductive traits, growth hormone (GHR), gonadotropin-releasing hormone receptor (GNRHR) and neuropeptide Y (NPY) were assessed for the association with the total egg production, number of ...
I C Dunn, A Morris, M N Romanov, Dunn, I C, Morris, A, Y W Miao, Romanov, Michael N, Wilson, P W, Waddington, David, D Waddington, Miao, Yi-Wei, P W Wilson   +11 more
core   +1 more source

Identification of Key Genes Associated with Lycopene Accumulation in Red Carrot Taproots Based on WGCNA

Agronomy
Lycopene (carotenoid) is a natural pigment with strong antioxidant properties. The taproots of red carrots (Daucus carota L.) exhibit red coloration due to the presence of high levels of lycopene.
Xiaoning An, Yanan Zhang, Hang Zhang, Xinyu Zhang, Lixia Li, Dan Luo, Zhe Wu   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Integrating transcriptomics and proteomics to analyze new regulatory genes related to rice grain development

Food Chemistry: Molecular Sciences
The regulation of seed size in rice represents a significant concern within the domain of developmental biology. Nevertheless, our understanding of the mechanisms by which plants determine seed size remains limited, despite its critical importance.
Zhixuan Du, Qitao Su, Haihui Fu, Dahu Zhou, Linjuan Ouyang, Junru Fu, Haohua He   +6 more
doaj   +1 more source

Identification of quantitative trait loci (QTL) and meta-QTL analysis for kernel size-related traits in wheat (Triticum aestivum L.)

BMC Plant Biology, 2022
Background Kernel size-related traits, including kernel length (KL), kernel width (KW), kernel diameter ratio (KDR) and kernel thickness (KT), are critical determinants for wheat kernel weight and yield and highly governed by a type of quantitative ...
Jingfu Ma, Yuan Liu, Peipei Zhang, Tao Chen, Tian Tian, Peng Wang, Zhuo Che, Fahimeh Shahinnia, Delong Yang   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source