Results 61 to 70 of about 1,393,284 (302)

Evaluating historical candidate genes for schizophrenia [PDF]

Molecular Psychiatry, 2015
Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (e.g., COMT, DISC1, DTNBP1, and NRG1).
Farrell, M. S., Werge, T., Sklar, P., Owen, M. J., Ophoff, R. A., O'Donovan, M. C., Corvin, A., Cichon, S., Sullivan, P. F.   +8 more
openaire   +5 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Identification of Key Genes Associated with Lycopene Accumulation in Red Carrot Taproots Based on WGCNA

Agronomy
Lycopene (carotenoid) is a natural pigment with strong antioxidant properties. The taproots of red carrots (Daucus carota L.) exhibit red coloration due to the presence of high levels of lycopene.
Xiaoning An, Yanan Zhang, Hang Zhang, Xinyu Zhang, Lixia Li, Dan Luo, Zhe Wu   +6 more
doaj   +1 more source

Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study

BMC Medical Genetics, 2017
Background Essential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular endothelium and is produced in endothelial cells by the enzyme endothelial nitric ...
Sahar Gamil, Jeanette Erdmann, Ihab B. Abdalrahman, Abdelrahim O. Mohamed   +3 more
doaj   +1 more source

Genetic Dissection of Phosphorous Uptake and Utilization Efficiency Traits Using GWAS in Mungbean

Agronomy, 2021
Mungbean (Vignaradiata L. Wilczek) is an early maturing legume grown predominantly in Asia for its protein-rich seeds. P deficiency can lead to several physiological disorders which ultimately result in a low grain yield in mungbean.
Venkata Ravi Prakash Reddy, Shouvik Das, Harsh Kumar Dikshit, Gyan Prakash Mishra, Muraleedhar S. Aski, Akanksha Singh, Kuldeep Tripathi, Renu Pandey, Ruchi Bansal, Madan Pal Singh, Padmavati Ganpat Gore, Manjunatha P. B., Deepali Kothari, Neha Rai, RamaKrishnan M. Nair   +14 more
doaj   +1 more source

Mapping and candidate-gene screening of the novel Turnip mosaic virus resistance gene retr02 in Chinese cabbage (Brassica rapa L.) [PDF]

, 2013
The extreme resistance to Turnip mosaic virus observed in the Chinese cabbage (Brassica rapa) line, BP8407, is monogenic and recessive. Bulked segregant analysis was carried out to identify simple sequence repeat and Indel markers linked to this ...
Li, Fei, Qian, Wei, Sun, Rifei, Walsh, John A., Wang, Xiaowu, Wu, Jian, Zhang, Hui, Zhang, Shifan, Zhang, Shujiang   +8 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Integrating transcriptomics and proteomics to analyze new regulatory genes related to rice grain development

Food Chemistry: Molecular Sciences
The regulation of seed size in rice represents a significant concern within the domain of developmental biology. Nevertheless, our understanding of the mechanisms by which plants determine seed size remains limited, despite its critical importance.
Zhixuan Du, Qitao Su, Haihui Fu, Dahu Zhou, Linjuan Ouyang, Junru Fu, Haohua He   +6 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Cross-Disorder Analysis of De Novo Variants Increases the Power of Prioritising Candidate Genes

Life, 2021
De novo variants (DNVs) are critical to the treatment of neurodevelopmental disorders (NDDs). However, effectively identifying candidate genes in small cohorts is challenging in most NDDs because of high genetic heterogeneity.
Kuokuo Li, Zhengbao Ling, Tengfei Luo, Guihu Zhao, Qiao Zhou, Xiaomeng Wang, Kun Xia, Jinchen Li, Bin Li   +8 more
doaj   +1 more source