Results 41 to 50 of about 3,878,610 (315)

Screening for coping style increases the power of gene expression studies [PDF]

, 2009
<b>Background:</b> Individuals of many vertebrate species show different stress coping styles and these have a striking influence on how gene expression shifts in response to a variety of challenges.
Pilarczyk, Maciej, Kadri, S., Davinia Morera Capdevila, Felicity A, Capdevila, Davinia Morera, Laia Ribas, Felicity A Huntingford, Huntingford, Felicity A, Simon MacKenzie, Ribas, L., MacKenzie, Simon, Sunil Kadri, Morera Capdevila, Davinia, Ribas, Laia, Pilarczyk, M., Morera, Davinia, MacKenzie, S., Huntingford, F.A., Maciej Pilarczyk, Kadri, Sunil, Capdevila, D.M., Huntingford, Felicity A., Ribas Cabezas, Laia   +22 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population [PDF]

, 2009
Background: The PCK1 gene, encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), has previously been implicated as a candidate gene for type 2 diabetes (T2D) susceptibility.
Britten, Abigail C, Barnett Anthony H, Barnett, Anthony, Britten, Abigail C., Bellary, S, Barnett, Anthony H., Anthony H Barnett, Kumar Sudhesh, Rees, Simon D, Britten, Abigail, Sudhesh Kumar, O'Hare, J Paul, Kelly, M Ann, Rees, Simon D., Rees, Simon, Kelly, M. Ann, Kelly, Marilyn, Britten Abigail C, Kelly M Ann, Bellary, Srikanth, Rees Simon D, Srikanth Bellary, Abigail C Britten, J Paul O'Hare, Bellary Srikanth, O'Hare, JP, Kumar, Sudhesh, Barnett, Anthony H, Simon D Rees, Barnett, A. H., O'Hare J Paul, Kumar, S, O'Hare, J. Paul, M Ann Kelly   +33 more
core   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Association between ESR1 and RBP4 genes and litter size traits in a hyperprolific line of Landrace × Large White cross sows

Veterinární Medicína, 2019
This study was aimed at analysing single-nucleotide polymorphisms in the oestrogen receptor 1 (ESR1) and retinol-binding protein 4 (RBP4) genes in a hyperprolific line of Landrace × Large White (Topigs 20) cross sows (n = 101).
Sven Mencik, Vlado Vukovic, Marija Spehar, Mario Modric, Mario Ostovic, Anamaria Ekert Kabalin   +5 more
doaj   +1 more source

Fine Mapping and Candidate Gene Identification for the CapUp Locus Controlling Fruit Orientation in Pepper (Capsicum spp.)

Frontiers in Plant Science, 2021
The orientation of fruits is a distinguishing morphological feature of pepper (Capsicum spp.) varieties. The pendent (downward curved) growth of the fruit stalks, known as pedicels, is highly correlated with fruit weight and pedicel length.
Abate Mekonnen Solomon, Tae-Gun Kim, Koeun Han, Hea-Young Lee, Abhinandan Patil, Muhammad Irfan Siddique, Jeonghwan Ahn, Byoung-Cheorl Kang, Byoung-Cheorl Kang   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex [PDF]

, 2013
This work was part funded by the MRC.Background: The Coloboma mouse carries a similar to 2 cM deletion encompassing the SNAP25 gene and has a hyperactive phenotype similar to that of ADHD.
Matthews, Natasha, Vance, Alasdair, Joseph Wagner, Kent, L, Ziarih Hawi, Robyn H Wallace, Gill Michael, Natasha Matthews, Alasdair Vance, Butler, Tim J., Butler, TJ, Matthews Natasha, Wallace Robyn H., Kent Lindsey, Hawi Ziarih, Tim J Butler, Lindsey Kent, Wagner Joseph, Hawi, Z, Bellgrove Mark A., Hawi, Ziarih, Butler Tim J., Matthews, N, Wagner, Joseph, Bellgrove, MA, Vance, A, Kent, Lindsey, Gill, Michael, Wallace, Robyn H., Vance Alasdair, Wagner, J, Mark A Bellgrove, Wallace, RH, Michael Gill, Bellgrove, Mark A., Gill, M   +35 more
core   +2 more sources

Linkage disequilibrium, SNP frequency change due to selection, and association mapping in popcorn chromosome regions containing QTLs for quality traits

Genetics and Molecular Biology, 2016
The objectives of this study were to assess linkage disequilibrium (LD) and selection-induced changes in single nucleotide polymorphism (SNP) frequency, and to perform association mapping in popcorn chromosome regions containing quantitative trait loci ...
Geísa Pinheiro Paes, José Marcelo Soriano Viana, Fabyano Fonseca e Silva, Gabriel Borges Mundim   +3 more
doaj   +1 more source