Results 21 to 30 of about 755,351 (269)

Is Mortalin a Candidate Gene for T1DM ?

Autoimmunity, 2004
Mortalin has been found to be up-regulated by 2D-protein gel analysis in isolated rodent islets exposed to cytokines. In islets from two rat strains with different sensitivity to the toxic effects of cytokines we observed a significant difference in IL-1beta mediated mortalin expression.
Jesper, Johannesen, Angeles, Pie, Allan Ertmann, Karlsen, Zenia Marian, Larsen, Allan, Jensen, Henrik, Vissing, Ole Peter, Kristiansen, Flemming, Pociot, Jørn, Nerup   +8 more
openaire   +2 more sources

Evaluating historical candidate genes for schizophrenia [PDF]

Molecular Psychiatry, 2015
Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (e.g., COMT, DISC1, DTNBP1, and NRG1).
Farrell, M. S., Werge, T., Sklar, P., Owen, M. J., Ophoff, R. A., O'Donovan, M. C., Corvin, A., Cichon, S., Sullivan, P. F.   +8 more
openaire   +5 more sources

Fine Mapping and Candidate Gene Identification for the CapUp Locus Controlling Fruit Orientation in Pepper (Capsicum spp.)

Frontiers in Plant Science, 2021
The orientation of fruits is a distinguishing morphological feature of pepper (Capsicum spp.) varieties. The pendent (downward curved) growth of the fruit stalks, known as pedicels, is highly correlated with fruit weight and pedicel length.
Abate Mekonnen Solomon, Tae-Gun Kim, Koeun Han, Hea-Young Lee, Abhinandan Patil, Muhammad Irfan Siddique, Jeonghwan Ahn, Byoung-Cheorl Kang, Byoung-Cheorl Kang   +8 more
doaj   +1 more source

Mapping Novel Loci and Candidate Genes Associated with Cadmium Content in Maize Using Genome-Wide Association Analysis

Agriculture
Cadmium is a toxic, carcinogenic element that threatens food safety due to its tendency to be absorbed by plants along with essential nutrients. This study conducted a genome-wide association study (GWAS) using SNP genotyping data from 170 natural maize ...
Ruiqiang Lai, Xiaoming Xue, Zaid Chachar, Hang Zhu, Weiwei Chen, Xuhui Li, Yuanqiang Hu, Ming Chen, Xiangbo Zhang, Jiajia Li, Lina Fan, Yongwen Qi   +11 more
doaj   +1 more source

Heritability and candidate genes for endometriosis

Reproductive BioMedicine Online, 2003
Endometriosis is inherited in polygenic/multifactorial fashion, with recurrence risks of 5-7% for first-degree relatives. The current task is to determine the number and location of causative genes. This review initially supports the basis for polygenic/multifactorial inheritance and then outlines genome-wide strategies for identifying causative genes.
Joe Leigh, Simpson, Farideh, Bischoff
openaire   +2 more sources

Candidate genes in ocular dominance plasticity [PDF]

Frontiers in Neuroscience, 2012
Many studies have been devoted to the identification of genes involved in experience-dependent plasticity in the visual cortex. To discover new candidate genes, we have reexamined data from one such study on ocular dominance (OD) plasticity in recombinant inbred BXD mouse strains. We have correlated the level of plasticity with the gene expression data
Rietman, M.L., Sommeijer, J.-P., Levelt, C.N., Heimel, J.A., Brussaard, A.B., Borst, J.G.G., Elgersma, Y., Galjart, N., van der Horst, G.T., Pennartz, C.M., Smit, A.B., Spruijt, B.M., Verhage, M., de Zeeuw, C.I.   +13 more
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Association between ESR1 and RBP4 genes and litter size traits in a hyperprolific line of Landrace × Large White cross sows

Veterinární Medicína, 2019
This study was aimed at analysing single-nucleotide polymorphisms in the oestrogen receptor 1 (ESR1) and retinol-binding protein 4 (RBP4) genes in a hyperprolific line of Landrace × Large White (Topigs 20) cross sows (n = 101).
Sven Mencik, Vlado Vukovic, Marija Spehar, Mario Modric, Mario Ostovic, Anamaria Ekert Kabalin   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Identification of quantitative trait loci (QTL) and meta-QTL analysis for kernel size-related traits in wheat (Triticum aestivum L.)

BMC Plant Biology, 2022
Background Kernel size-related traits, including kernel length (KL), kernel width (KW), kernel diameter ratio (KDR) and kernel thickness (KT), are critical determinants for wheat kernel weight and yield and highly governed by a type of quantitative ...
Jingfu Ma, Yuan Liu, Peipei Zhang, Tao Chen, Tian Tian, Peng Wang, Zhuo Che, Fahimeh Shahinnia, Delong Yang   +8 more
doaj   +1 more source