Results 11 to 20 of about 1,393,284 (302)

Endometriosis: candidate genes [PDF]

Human Reproduction Update, 2001
Endometriosis is generally regarded as a benign disease but it does exhibit some characteristics reminiscent of malignancy. This raises the possibility that, like malignant diseases, the development of endometriosis may involve the acquisition of somatic genetic alterations in genes that regulate cell growth and differentiation.
I G, Campbell, E J, Thomas
openaire   +2 more sources

Identification of a Candidate Gene for Astigmatism [PDF]

Investigative Opthalmology & Visual Science, 2013
Astigmatism is a common refractive error that reduces vision, where the curvature and refractive power of the cornea in one meridian are less than those of the perpendicular axis. It is a complex trait likely to be influenced by both genetic and environmental factors.
Lopes, Margarida C., Hysi, Pirro G., Verhoeven, Virginie J. M., Macgregor, Stuart, Hewitt, Alex W., Montgomery, Grant W., Cumberland, Phillippa, Vingerling, Johannes R., Young, Terri L., van Duijn, Cornelia M., Oostra, Ben, Uitterlinden, Andre G., Rahi, Jugnoo S., Mackey, David A., Klaver, Caroline C. W., Andrew, Toby, Hammond, Christopher J.   +16 more
openaire   +5 more sources

Candidate gene prioritization with Endeavour [PDF]

Nucleic Acids Research, 2016
Genomic studies and high-throughput experiments often produce large lists of candidate genes among which only a few are truly relevant to the disease, phenotype, or biological process of interest. Gene prioritization tackles this problem by ranking candidate genes by profiling candidates across multiple genomic data sources and ...
Léon-Charles Tranchevent, Amin Ardeshirdavani, Sarah ElShal, Daniel Alcaide, Jan Aerts, Didier Auboeuf, Yves Moreau   +6 more
openaire   +3 more sources

Probing the Gene eXpression Database for candidate genes [PDF]

European Journal of Human Genetics, 1999
We report on a strategy for the identification of candidate genes for multiple malformation syndromes using expression data available in public databases. The basis for this pilot study was the assumption that, for a multiple malformation syndrome, the expression pattern of the causative gene should at least cover the organs or tissues affected by the ...
Steensel, M.A.M. van, Celli, J., Bokhoven, J.H.L.M. van, Brunner, H.G.   +3 more
openaire   +3 more sources

RNA-Seq Transcriptome Analysis of Potato with Differential Tolerance to Bentazone Herbicide

Agronomy, 2021
Potato (Solanum tuberosum), an important food crop worldwide, is threatened by broadleaf weeds. Bentazone is an effective herbicide for controlling weeds; however, as a photosynthesis inhibitor, it can also affect potato plants.
Jing Guo, Xiuli Song, Shiqi Sun, Baihui Shao, Bo Tao, Lili Zhang   +5 more
doaj   +1 more source

Gene Expression in Experimental Aortic Coarctation and Repair: Candidate Genes for Therapeutic Intervention? [PDF]

, 2015
Coarctation of the aorta (CoA) is a constriction of the proximal descending thoracic aorta and is one of the most common congenital cardiovascular defects.
Bozdag, Serdar, Eddinger, Thomas J., Kersten, Judy R., LaDisa, John F., Jr., Olson, Jessica, Ramchandran, Ramani   +5 more
core   +14 more sources

Prediction of gene–phenotype associations in humans, mice, and plants using phenologs [PDF]

, 2013
All authors are with the Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
Laurent, Jon M., Marcotte, Edward M., McGary, Kriston L., Singh-Blom, Ulf Martin, Woods, John O.   +4 more
core   +2 more sources

miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS. [PDF]

, 2019
ObjectiveOnset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small ...
Aaen, Gregory, Barcellos, Lisa F, Belman, Anita, Benson, Leslie, Caillier, Stacy, Candee, Meghan S, Casper, T Charles, Chitnis, Tanuja, Gorman, Mark, Graves, Jennifer S, Greenberg, Benjamin M, Harris, Yolanda, Hart, Janace, Kahn, Ilana, Krupp, Lauren, Lotze, Timothy, Mar, Soe, Ness, Jayne, Quach, Diana, Quach, Hong, Rhead, Brooke, Rodriguez, Moses, Rose, John, Rubin, Jennifer, Schaefer, Catherine, Schreiner, Teri, Shao, Xiaorong, Tillema, Jan M, US Network of Pediatric MS Centers, Waldman, Amy T, Waubant, Emmanuelle, Weinstock-Guttman, Bianca   +31 more
core   +2 more sources

Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood

BMC Medical Genetics, 2017
Background Osteoporosis individual susceptibility is determined by the interaction of multiple genetic variants and environmental factors. The aim of this study was to conduct SNP-SNP interaction analyses in candidate genes influencing heel quantitative ...
María Correa-Rodríguez, Sebastien Viatte, Jonathan Massey, Jacqueline Schmidt-RioValle, Blanca Rueda-Medina, Gisela Orozco   +5 more
doaj   +1 more source

Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease [PDF]

, 2019
Differences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors
Nowick, Katja, Perdomo-Sabogal, Álvaro
core   +1 more source