Results 11 to 20 of about 757,405 (266)

Endometriosis: candidate genes [PDF]

Human Reproduction Update, 2001
Endometriosis is generally regarded as a benign disease but it does exhibit some characteristics reminiscent of malignancy. This raises the possibility that, like malignant diseases, the development of endometriosis may involve the acquisition of somatic genetic alterations in genes that regulate cell growth and differentiation.
I G, Campbell, E J, Thomas
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Identification of a Candidate Gene for Astigmatism [PDF]

Investigative Opthalmology & Visual Science, 2013
Astigmatism is a common refractive error that reduces vision, where the curvature and refractive power of the cornea in one meridian are less than those of the perpendicular axis. It is a complex trait likely to be influenced by both genetic and environmental factors.
Lopes, Margarida C., Hysi, Pirro G., Verhoeven, Virginie J. M., Macgregor, Stuart, Hewitt, Alex W., Montgomery, Grant W., Cumberland, Phillippa, Vingerling, Johannes R., Young, Terri L., van Duijn, Cornelia M., Oostra, Ben, Uitterlinden, Andre G., Rahi, Jugnoo S., Mackey, David A., Klaver, Caroline C. W., Andrew, Toby, Hammond, Christopher J.   +16 more
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Candidate gene prioritization with Endeavour [PDF]

Nucleic Acids Research, 2016
Genomic studies and high-throughput experiments often produce large lists of candidate genes among which only a few are truly relevant to the disease, phenotype, or biological process of interest. Gene prioritization tackles this problem by ranking candidate genes by profiling candidates across multiple genomic data sources and ...
Léon-Charles Tranchevent, Amin Ardeshirdavani, Sarah ElShal, Daniel Alcaide, Jan Aerts, Didier Auboeuf, Yves Moreau   +6 more
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Probing the Gene eXpression Database for candidate genes [PDF]

European Journal of Human Genetics, 1999
We report on a strategy for the identification of candidate genes for multiple malformation syndromes using expression data available in public databases. The basis for this pilot study was the assumption that, for a multiple malformation syndrome, the expression pattern of the causative gene should at least cover the organs or tissues affected by the ...
Steensel, M.A.M. van, Celli, J., Bokhoven, J.H.L.M. van, Brunner, H.G.   +3 more
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STK25 Is a Candidate Gene for Pseudopseudohypoparathyroidism

Genomics, 2001
We determined the chromosomal location of the mouse gene Stk25, encoding a member of the Ste20/PAK family of serine/threonine kinases, by interspecific backcross analysis. We mapped Stk25 to the central region of mouse chromosome 1 linked to Chrng (formerly Acrg) and En1.
Davids, M S, Crawford, E, Weremowicz, S, Morton, C C; id_orcid 0000-0003-2198-6756, Copeland, N G, Gilbert, D J, Jenkins, N A, Phelan, M C, Comb, M J, Melnick, M B   +9 more
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Deciphering the Genetic Alterations in PIK3CA Gene Interacting Network and Their Putative Association with Breast Cancer: A Computational Approach [PDF]

Middle East Journal of Cancer
Background: Cancer is a polygenic complex disorder involving a network of genes. The phosphatidylinositol 3-kinase (PIK3CA) has been reported as an oncogene that plays a role in many cancer types.
Sivapriya Dayakar, Anitha Pandi, Chandra Pandi, Paramasivam Arumugam, Vijayashree Priyadharsini Jayaseelan   +4 more
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Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers

Translational Neuroscience, 2016
Population stratification of functional gene polymorphisms is a potential confounding factor in genetic association studies. The Val66Met (rs6265) single-nucleotide polymorphism in the brain-derived neurotrophic factor gene (BDNF) exhibits one of the ...
Vulturar Romana, Chiş Adina, Hambrich Melinda, Kelemen Beatrice, Ungureanu Loredana, Miu Andrei C.   +5 more
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Candidate and non-candidate genes in behavior genetics

Current Opinion in Neurobiology, 2013
In this review we discuss recent developments in psychiatric genetics: on the one hand, studies using whole genome approaches (genome-wide association studies (GWAS) and exome sequencing) are coming close to finding genes and molecular variants that contribute to disease susceptibility; on the other candidate genes, such as the serotonin transporter ...
Flint, Jonathan, Munafò, Marcus R
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CD14 GENE AS A CANDIDATE GENE FOR IMMUNOMODULATION : A REVIEW [PDF]

Exploratory Animal and Medical Research, 2012
CD14 molecule and CD14 gene has been characterized in various livestock species. Structural analysis of CD14 molecule and CD14 gene encoding it is helpful for understanding its function for immuno-modulation. CD14 gene has been observed to be highly
Aruna Pa, P.N. Chatterjee, U.K. Karmakar, Sanjoy Datta, A.K. Saren   +4 more
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Bioinformatics methods for identifying candidate disease genes

Human Genomics, 2006
With the explosion in genomic and functional genomics information, methods for disease gene identification are rapidly evolving. Databases are now essential to the process of selecting candidate disease genes.
van Driel Marc A, Brunner Han G
doaj   +1 more source