Results 131 to 140 of about 1,412,519 (351)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Comparative mapping combined with homology-based cloning of the rice genome reveals candidate genes for grain zinc and iron concentration in maize [PDF]
, 2015 Tiantian Jin +5 more
openalex +1 more source
Association analysis of polymorphisms of candidate genes for laying traits in Yangzhou geese
, 2023 Yang Zhang +6 more
openalex +1 more source
Time Series Data Mining Algorithms for Identifying Short RNA in Arabidopsis thaliana [PDF]
, 2007 The class of molecules called short RNAs (sRNAs) are known to play a key role in gene regulation. Th are typically sequences of nucleotides between 21-25 nucleotides in length. They are known to play a key role in gene regulation.
Bagnall, Anthony +2 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Candidate Gene Identification Approach: Progress and Challenges
International Journal of Biological Sciences, 2007 Although it has been widely applied in identification of genes responsible for biomedically, economically, or even evolutionarily important complex and quantitative traits, traditional candidate gene approach is largely limited by its reliance on the ...
Mengjin Zhu, Shuhong Zhao
doaj
Identifying the candidate genes involved in the calyx abscission process of 'Kuerlexiangli’ (Pyrus sinkiangensis Yu) by digital transcript abundance measurements [PDF]
, 2013 Xiaoxiao Qi +7 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source