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Candidate Genes for Osteoporosis
American Journal of PharmacoGenomics, 2001Osteoporosis, which afflicts 10 million Americans, is a complex disease characterized by decreased bone mass, microarchitectural deterioration of bone tissue, and an increase in fracture risk. Family and twin studies have established a genetic contribution to the etiology of osteoporosis.
T, Niu, X, Xu
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POLYMORPHISMS OF CANDIDATE GENES IN ESSENTIAL HYPERTENSION
Clinical and Experimental Pharmacology and Physiology, 1992SUMMARY1. Family and population studies have reported that blood pressure has a heritability of 30–50%, but simple genetic models do not readily explain the patterns of inheritance of hypertension.2. Restriction fragment length polymorphisms were used to study allele frequencies of a selection of candidate genes that may be important in determining the
West, M. J. +2 more
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Emotion, 2015
The discovery of genetic variants associated with psychological traits deepens our knowledge about causes and consequences of individual differences. In psychology, the standard approach to identify these variants is the "candidate gene study." In a candidate gene study, a limited set of genetic variants is selected based on their hypothesized or known
Aysu Okbay, Cornelius A. Rietveld
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The discovery of genetic variants associated with psychological traits deepens our knowledge about causes and consequences of individual differences. In psychology, the standard approach to identify these variants is the "candidate gene study." In a candidate gene study, a limited set of genetic variants is selected based on their hypothesized or known
Aysu Okbay, Cornelius A. Rietveld
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Selection of Candidate Genes in Hypertension
2005Essential hypertension is a common disease with multifactorial etiology affecting up to 10 million individuals in the United Kingdom alone. Current knowledge of the genetic contribution to this trait is restricted to a number of rare variants that produce hypertensive phenotypes in a Mendelian fashion and to genes highlighted by work on blood pressure ...
Charles A, Mein +2 more
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Journal of Animal Breeding and Genetics, 2010
Lehden pääkirjoitus ; v ; 2011 ...
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Lehden pääkirjoitus ; v ; 2011 ...
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Candidate Gene Association Studies
2010Candidate gene association studies aim to establish or characterise association between the genetic -variation occurring within a specific gene or locus and a phenotype. If the phenotype is quantitative, then the effect size is often measured as the difference between the genotype specific means or a per allele effect.
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Candidate Gene Association Analysis
2009Candidate gene association study is the most common method for associating human genetic variations with the phenotypes they produce, due to the relative simplicity of acquiring patient samples and genotype data. The study design begins with identifying appropriate DNA samples and an appropriate phenotype for analysis.
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Candidate gene prioritization.
Molecular genetics and genomics : MGG, 2012Candidate gene identification is typically labour intensive, involving laboratory experiments required to corroborate or disprove any hypothesis for a nominated candidate gene being considered the causative gene. The traditional approach to reduce the number of candidate genes entails fine-mapping studies using markers and pedigrees.
Ali, Masoudi-Nejad +3 more
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