Results 101 to 110 of about 1,155,248 (307)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Candidate orphan genes: Reassessing uniqueness.

PLoS ONE
Orphan genes lack recognizable homologues outside a given taxonomic unit; thus, they have uncertain evolutionary origins. This presents a profound challenge to traditional models of gene evolution.
Sheetalpreet K Maan, Xuan Y Butzin, Steven X Ge, Nicholas C Butzin   +3 more
doaj   +1 more source

Polymorphisms in swine candidate genes for meat quality detected by PCR-SSCP

Italian Journal of Animal Science, 2010
In order to identify SNPs in seven candidate genes for meat quality, PCR-SSCP experiments were carried out. Statistical analyses in a population of 240 individuals identified the animals constituting the extreme tails of the Gaussian distribution for ...
Stefania Chessa, Bianca Castiglioni, Giulio Pagnacco, Daniela Rignanese, Marta Raschetti   +4 more
doaj   +1 more source

Phenotypic Expression of Two Candidate Genes of Nonsyndromic Craniosynostosis in Danio rerio [PDF]

, 2020
Phenotypic Expression of Two Candidate Genes of Nonsyndromic Craniosynostosis in Danio rerio Annemarie Carver, Dept. of Biology with Dr. Rita Shiang, Dept.
Carver, Annemarie
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Homozygosity Mapping and Genetic Analysis of Autosomal Recessive Retinal Dystrophies in 144 Consanguineous Pakistani Families. [PDF]

, 2017
PurposeThe Pakistan Punjab population has been a rich source for identifying genes causing or contributing to autosomal recessive retinal degenerations (arRD).
Akram, Javed, Ayyagari, Radha, Cabrera, Patricia E, Chen, Jianjun, Chen, Yabin, Govindarajan, Gowthaman, Gupta, Nikhil, Hejtmancik, J Fielding, Huang, Li, Jiang, Dan, Jiao, Xiaodong, Jin, Chongfei, Khan, Shaheen N, Li, Jiali, Li, Lin, M'hamdi, Oussama, Ma, Xiaoyin, Ma, Yan, Ma, Zhiwei, Naeem, Muhammad Asif, Riazuddin, S Amer, Riazuddin, Sheikh, Sieving, Paul A, Sun, Wenmin, Tanwar, Mukesh   +24 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Integrative transcriptome and genome resequencing reveals conserved flowering regulators and allelic variants in early- and late-flowering linseed (Linum usitatissimum L.) accessions

Scientific Reports
Flaxseed/Linseed (Linum usitatissimum) is an annual crop of economic importance due to its diverse applications in food, nutraceuticals, and industry. Flowering time is a crucial trait in linseed; however, the gene expression landscapes underlying its ...
Deepa Pal, Daniya Shahid, Ankit Saroha, Akash, Vikender Kaur, J. Aravind, M. Z. Abdin, S. Rajkumar, Rakesh Singh, Gyanendra Pratap Singh, Dhammaprakash Pandhari Wankhede   +10 more
doaj   +1 more source

The association of CAPN1, CAST, SCD, and FASN polymorphisms with beef quality traits in commercial crossbred cattle in the Czech Republic

Czech Journal of Animal Science, 2013
Genetic variability of four polymorphisms (CAPN1, CAST, SCD, and FASN) was evaluated and the relationships between them and the beef quality traits (tenderness and fatty acid composition) in Czech crossbred cattle population were assessed.
K. Kaplanová, A. Dufek, E. Dračková, J. Simeonovová, J. Šubrt, I. Vrtková, J. Dvořák   +6 more
doaj   +1 more source

Identification of candidate genes affecting Delta9-tetrahydrocannabinol biosynthesis in Cannabis sativa. [PDF]

, 2009
RNA isolated from the glands of a Delta(9)-tetrahydrocannabinolic acid (THCA)-producing strain of Cannabis sativa was used to generate a cDNA library containing over 100 000 expressed sequence tags (ESTs).
Dixon, Richard A, Gang, David R, He, Ji, Marks, M David, Omburo, Stephanie N, Soto-Fuentes, Wilfredo, Tian, Li, Weiblen, George D, Wenger, Jonathan P   +8 more
core