Results 91 to 100 of about 1,155,248 (307)

Identification of T-cell receptor a-chain genes in the chicken [PDF]

, 1994
T-cell receptor (TCR) -chain (TCR) and ß-chain (TCRß) genes are well characterized in mammals, while only TCRß genes have been identified in other vertebrates. To identify avian TCR genes, we used monoclonal anti-CD3 antibodies to isolate chicken TCR for
Aebersold, Ruedi, Chen, Chen-Lo H., Cooper, Max D., Göbel, Thomas W. F., Hood, Leroy, Kubota, Takayuki, Kuo, Chia-Lam, Lahti, Jill   +7 more
core  

The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo [PDF]

, 2005
Maternal and zygotic activities of the homeodomain protein PAL-1 specify the identity and maintain the development of the multipotent C blastomere lineage in the C. elegans embryo. To identify PAL-1 regulatory target genes, we used microarrays to compare
Baugh, L. Ryan, Brown, Eugene L., Claggett, Julia M., Hill, Andrew A., Hill-Harfe, Kate, Hunter, Craig P., Slonim, Donna K., Wen, Joanne C.   +7 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in \u3cem\u3ePlasmodium falciparum\u3c/em\u3e

, 2010
Background: Elevated parasite biomass in the human red blood cells can lead to increased malaria morbidity. The genes and mechanisms regulating growth and development of Plasmodium falciparum through its erythrocytic cycle are not well understood.
Ferdig, Michael T., Reilly Ayala, Heather B., Siwo, Geoffrey, Wacker, Mark A   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Molecular basis of human essential hypertension.

Journal of Bahria University Medical and Dental College, 2011
Essential hypertension (HTN) affects over one billion people worldwide. It is a complex, multifactorial, quantitative trait under polygenic control resulting from inheritance of a number of susceptibility genes and involves multiple environmental ...
Sadiqa Syed, Masood A Qureshi
doaj  

Testing for variation in photoperiodic plasticity in a butterfly: Inconsistent effects of circadian genes between geographic scales

Ecology and Evolution
The genetic components of the circadian clock have been implicated as involved in photoperiodic regulation of winter diapause across various insect groups, thereby contributing to adaptation to adverse seasonal conditions.
Olle Lindestad, Sören Nylin, Christopher W. Wheat, Karl Gotthard   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Association of the CTSB, CTSF and CSTB genes with growth, carcass and meat quality traits in heavy pigs

Italian Journal of Animal Science, 2011
The production of dry cured hams of high quality is the main aim of the Italian pork industry that is based on the breeding of heavy pigs (Russo and Nanni Costa, 1995).
R. Virgili, S. Galli, C. Baiocco, L. Buttazzoni, L. Fontanesi, L. Nanni Costa, R. Davoli, V. Russo   +7 more
doaj   +1 more source

[Genes and kidney disease. Candidate genes].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2002
80
Rodríguez Pérez, J. C., Rodríguez Esparragón, F., Torres, M. J., Hernández Perera, O.   +3 more
openaire   +2 more sources