Results 71 to 80 of about 33,220 (219)

Genetic dissection of quantitative and qualitative traits using a minimum set of barley Recombinant Chromosome Substitution Lines

BMC Plant Biology, 2018
Background Exploring the natural occurring genetic variation of the wild barley genepool has become a major target of barley crop breeding programmes aiming to increase crop productivity and sustainability in global climate change scenarios. However this
Carla De la Fuente Cantó, Joanne Russell, Christine A. Hackett, Allan Booth, Siobhan Dancey, Timothy S. George, Robbie Waugh   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spicy genes: mapping quantitative genomic regions and candidate genes for capsaicinoid and capsinoid biosynthesis in pepper

Frontiers in Plant Science
Capsaicinoids, the molecules responsible for pungency in pepper (Capsicum spp.), and their non-pungent analogs, capsinoids, are synthesized through the interaction of two distinct metabolic pathways: the branched chain fatty acid pathway and the ...
Edoardo Vergnano, Matteo Martina, Peter Poláček, Yury Tikunov, Luciana Gaccione, Lorenzo Barchi, Arnaud Bovy, Ezio Portis   +7 more
doaj   +1 more source

Association of the CTSB, CTSF and CSTB genes with growth, carcass and meat quality traits in heavy pigs

Italian Journal of Animal Science, 2011
The production of dry cured hams of high quality is the main aim of the Italian pork industry that is based on the breeding of heavy pigs (Russo and Nanni Costa, 1995).
R. Virgili, S. Galli, C. Baiocco, L. Buttazzoni, L. Fontanesi, L. Nanni Costa, R. Davoli, V. Russo   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Detection of closely linked QTLs and candidate genes controlling germination indices in response to drought and salinity stresses in barley

Scientific Reports
The aim of current study was to identify closely linked QTLs and candidate genes related to germination indices under control, salinity and drought conditions in barley.
Hossein Sabouri, Zahra Pezeshkian, Fakhtak Taliei, Mahjoubeh Akbari, Borzo Kazerani   +4 more
doaj   +1 more source

Polymorphisms in swine candidate genes for meat quality detected by PCR-SSCP

Italian Journal of Animal Science, 2010
In order to identify SNPs in seven candidate genes for meat quality, PCR-SSCP experiments were carried out. Statistical analyses in a population of 240 individuals identified the animals constituting the extreme tails of the Gaussian distribution for ...
Stefania Chessa, Bianca Castiglioni, Giulio Pagnacco, Daniela Rignanese, Marta Raschetti   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

BEEF CATTLE MUSCULARITY CANDIDATE GENES

Jurnal Ilmu-Ilmu Peternakan, 2010
Muscularity is a potential indicator for the selection of more productive cattle. Mapping quantitative trait loci (QTL) for traits related to muscularity is useful to identify the genomic regions where the genes affecting muscularity reside. QTL analysis
Irida Novianti, Waynes S. Pitchford, Cynthia D. K. Bottema   +2 more
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