Results 71 to 80 of about 662,534 (268)

Integrative transcriptome and genome resequencing reveals conserved flowering regulators and allelic variants in early- and late-flowering linseed (Linum usitatissimum L.) accessions

Scientific Reports
Flaxseed/Linseed (Linum usitatissimum) is an annual crop of economic importance due to its diverse applications in food, nutraceuticals, and industry. Flowering time is a crucial trait in linseed; however, the gene expression landscapes underlying its ...
Deepa Pal, Daniya Shahid, Ankit Saroha, Akash, Vikender Kaur, J. Aravind, M. Z. Abdin, S. Rajkumar, Rakesh Singh, Gyanendra Pratap Singh, Dhammaprakash Pandhari Wankhede   +10 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

The association of CAPN1, CAST, SCD, and FASN polymorphisms with beef quality traits in commercial crossbred cattle in the Czech Republic

Czech Journal of Animal Science, 2013
Genetic variability of four polymorphisms (CAPN1, CAST, SCD, and FASN) was evaluated and the relationships between them and the beef quality traits (tenderness and fatty acid composition) in Czech crossbred cattle population were assessed.
K. Kaplanová, A. Dufek, E. Dračková, J. Simeonovová, J. Šubrt, I. Vrtková, J. Dvořák   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Detection of closely linked QTLs and candidate genes controlling germination indices in response to drought and salinity stresses in barley

Scientific Reports
The aim of current study was to identify closely linked QTLs and candidate genes related to germination indices under control, salinity and drought conditions in barley.
Hossein Sabouri, Zahra Pezeshkian, Fakhtak Taliei, Mahjoubeh Akbari, Borzo Kazerani   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

BEEF CATTLE MUSCULARITY CANDIDATE GENES

Jurnal Ilmu-Ilmu Peternakan, 2010
Muscularity is a potential indicator for the selection of more productive cattle. Mapping quantitative trait loci (QTL) for traits related to muscularity is useful to identify the genomic regions where the genes affecting muscularity reside. QTL analysis
Irida Novianti, Waynes S. Pitchford, Cynthia D. K. Bottema   +2 more
doaj  

Spicy genes: mapping quantitative genomic regions and candidate genes for capsaicinoid and capsinoid biosynthesis in pepper

Frontiers in Plant Science
Capsaicinoids, the molecules responsible for pungency in pepper (Capsicum spp.), and their non-pungent analogs, capsinoids, are synthesized through the interaction of two distinct metabolic pathways: the branched chain fatty acid pathway and the ...
Edoardo Vergnano, Matteo Martina, Peter Poláček, Yury Tikunov, Luciana Gaccione, Lorenzo Barchi, Arnaud Bovy, Ezio Portis   +7 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source