Results 201 to 210 of about 1,170,895 (233)

SNPing Away at Candidate Genes

Genetic Epidemiology, 2001
We develop regression methodology to identify subsets of single nucleotide polymorphisms (SNPs) within candidate genes related to quantitative traits and apply our methods to the simulated Genetic Analysis Workshop (GAW) 12 data set. In the data set we find 694 SNP loci with minimum allele frequencies of at least 0.01.
M A, Suchard, J N, Bailey, D A, Elashoff, J S, Sinsheimer   +3 more
openaire   +2 more sources

Candidate Genes for Osteoporosis

American Journal of PharmacoGenomics, 2001
Osteoporosis, which afflicts 10 million Americans, is a complex disease characterized by decreased bone mass, microarchitectural deterioration of bone tissue, and an increase in fracture risk. Family and twin studies have established a genetic contribution to the etiology of osteoporosis.
T, Niu, X, Xu
openaire   +2 more sources

Candidate Genes for Insulin Resistance

Diabetes Care, 1996
Insulin resistance confers increased susceptibility to NIDDM, atherosclerotic cardiovascular disease, ovarian hyperandrogenism, and possibly hypertension. Insulin resistance is largely inherited, in rare cases as a monogenic disorder or more commonly as a complex trait.
D E, Moller, C, Bjørbaek, A, Vidal-Puig
openaire   +2 more sources

Pharmacogenetic Candidate Genes for Melanoma

Pharmacogenomics, 2003
The incidence of melanoma is rising at an alarming rate and has become an important public health concern. If detected early, melanoma carries an excellent prognosis after appropriate surgical resection. Unfortunately, advanced melanoma has a poor prognosis and is notoriously resistant to radiation and chemotherapy.
Christopher, Hull, April, Larson, Sancy, Leachman   +2 more
openaire   +2 more sources

Candidate Gene Association Analysis

2009
Candidate gene association study is the most common method for associating human genetic variations with the phenotypes they produce, due to the relative simplicity of acquiring patient samples and genotype data. The study design begins with identifying appropriate DNA samples and an appropriate phenotype for analysis.
openaire   +2 more sources

Polymorphisms in Candidate Asthma Genes

The American Journal of the Medical Sciences, 2001
The triad of reversible airway obstruction, bronchial hyperresponsiveness, and airway inflammation characterizes asthma. The etiology of asthma is complex and involves the interaction of multiple genetic foci and a variety of environmental factors, such as protein allergens, chemical sensitizers, and viral or bacterial proteins.
U, Nanavaty, A D, Goldstein, S J, Levine
openaire   +2 more sources

Candidate genes for behavioural ecology

Trends in Ecology & Evolution, 2005
In spite of millions of years of evolutionary divergence, the conservation of gene function is common across distant lineages. As such, genes that are known to influence behaviour in one organism are likely to influence similar behaviours in other organisms.
Fitzpatrick, M.J., Ben-Sahar, Y., Smid, H.M., Vet, L.E.M., Robinson, G.E., Sokolowski, M.B.   +5 more
openaire   +3 more sources

Candidate Gene Association Studies

2010
Candidate gene association studies aim to establish or characterise association between the genetic -variation occurring within a specific gene or locus and a phenotype. If the phenotype is quantitative, then the effect size is often measured as the difference between the genotype specific means or a per allele effect.
openaire   +2 more sources

Candidate Genes in Eating Disorders

Current Drug Target -CNS & Neurological Disorders, 2003
Environmental influences, as well as biological and genetic factors influence risk for eating disorders. Family and twin studies have shown that eating disorders are familial and suggest the influence of genetic factors on their etiology. Positive associations have been observed for some candidate genes that have been studied (such as 5HT2A receptor ...
Federica, Tozzi, Cynthia M, Bulik
openaire   +2 more sources

Candidate gene case-control studies

Pharmacogenomics, 2003
Two main approaches to the identification of genes are involved in polygenic diseases. Use of family studies has generally been the preferred approach up until recently, but this is only feasible if the genetic component of the disease is relatively strong and DNA samples are available from other family members.
openaire   +2 more sources