Results 41 to 50 of about 690,878 (269)

Genome-wide detection of selective signatures in a Duroc pig population

Journal of Integrative Agriculture, 2018
The Duroc pig has high adaptability and feeding efficiency, making it one of the most popular pig breeds worldwide. Over long periods of natural and artificial selection, genetic footprints, i.e., selective signatures, were left in the genome.
Shu-qi DIAO, Yuan-yu LUO, Yun-long MA, Xi DENG, Ying-ting HE, Ning GAO, Hao ZHANG, Jia-qi LI, Zan-mou CHEN, Zhe ZHANG   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Is Mortalin a Candidate Gene for T1DM ?

Autoimmunity, 2004
Mortalin has been found to be up-regulated by 2D-protein gel analysis in isolated rodent islets exposed to cytokines. In islets from two rat strains with different sensitivity to the toxic effects of cytokines we observed a significant difference in IL-1beta mediated mortalin expression.
Jesper, Johannesen, Angeles, Pie, Allan Ertmann, Karlsen, Zenia Marian, Larsen, Allan, Jensen, Henrik, Vissing, Ole Peter, Kristiansen, Flemming, Pociot, Jørn, Nerup   +8 more
openaire   +2 more sources

Whole-Genome Sequencing in Premature Coronary Artery Disease in South Asians: A Pilot Case–Control Study

Cardiogenetics
Background/Objectives: Coronary artery disease (CAD) remains the leading cause of mortality worldwide, with South Asia bearing a disproportionately high and rising burden, particularly at younger ages.
Iftikhar Ali Ch, Azhar Chaudhry, Fazal Jalil, Yasir Ali, Waseem Iqbal, Yusra Javed, Salman Khalid, Azeen Razzaq, Muhammad Azhar, Amna Nadeem, Tayyab Afzal, Naeem Tahirkheli, Ankur Kalra, Khurram Nasir   +13 more
doaj   +1 more source

Potential biomarkers in personality disorders: current state and future research

International Journal of Psychological Research, 2016
This review article presents the most appropriate strategies for examining the phenotype for personality disorders. At present there are many neurobiological and molecular studies that suggest a genetic predisposition to different traits representative ...
Manuela Valencia Piedrahita, Jorge Mauricio Cuartas Arias   +1 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Candidate genes of Waldenström’s macroglobulinemia: current evidence and research

The Application of Clinical Genetics, 2013
Giada Bianchi,1 Antonio Sacco,1 Shaji Kumar,2 Giuseppe Rossi,3 Irene Ghobrial,1 Aldo Roccaro11Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 2Division of Hematology, Mayo Clinic, Rochester, MN, USA ...
Bianchi G, Sacco A, Kumar S, Rossi G, Ghobrial I, Roccaro A   +5 more
doaj  

Evolution of genes involved in feeding preference and metabolic processes in Calliphoridae (Diptera: Calyptratae) [PDF]

PeerJ, 2016
Background The genotype-phenotype interactions among traits governing feeding preference are of fundamental importance to behavioral genetics and evolutionary biology.
Gisele Antoniazzi Cardoso, Marco Antonio Tonus Marinho, Raquel Dietsche Monfardini, Ana Maria Lima de Azeredo Espin, Tatiana Teixeira Torres   +4 more
doaj   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source