Results 81 to 90 of about 13,407 (217)

The role of T cells in sepsis of distinct infectious aetiologies

open access: yesClinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu   +5 more
wiley   +1 more source

Nineteen years retrospective analysis of epidemiology, antifungal resistance and a nomogram model for 30-day mortality in nosocomial candidemia patients

open access: yesFrontiers in Cellular and Infection Microbiology
BackgroundThe incidence of nosocomial candidemia has increased in recently years, however, the epidemiological data remain insufficient in China.MethodsA total of 234 candidemia patients were included from Xiamen University Zhong Shan hospital between ...
Zhang Dai   +11 more
doaj   +1 more source

Risk Factors and Pathogenic Bacteria Prevalence in Catheter‐Associated Blood Stream Infection in Patients Undergoing Hemodialysis: A Cross‐Sectional Study

open access: yesHealth Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Catheter‐associated bloodstream infections (CABSI) cause a significant clinical and financial burden in nephrology. This study aimed to identify the clinical risk factors and prevalent pathogens associated with CABSI among hemodialysis (HD) patients at a tertiary care hospital in Pakistan. Methods This cross‐sectional study
Muhammad Shaheer Bin Faheem   +6 more
wiley   +1 more source

Bactericidal, Bacteriostatic, and Fungicidal Activities of Clausena anisata Fruit and Its Compounds, Stigmasteryl 3‐Palmitate (a Phytosterol Ester) and Phellopterin (a Furanocoumarin), Against Some Clinical Pathogens

open access: yesMicrobiologyOpen, Volume 15, Issue 2, April 2026.
C. anisata fruit extract and its compounds demonstrated potent broad‐spectrum antimicrobial activity, notably against Klebsiella pneumoniae (MIC 0.625 mg/mL; MLC 2.5 mg/mL) and Candida albicans (MIC 0.0781 mg/mL; MLC 0.625 mg/mL). The findings highlight promising bactericidal and fungicidal potential of stigmasteryl 3‐palmitate and phellopterin against
Emmanuel Kofi Kumatia   +5 more
wiley   +1 more source

Epidemiology, species distribution, and predictive factors for mortality of candidemia in adult surgical patients

open access: yesBMC Infectious Diseases, 2020
Background We evaluated the epidemiology, clinical characteristics, microbiology, outcomes, and risk factors for mortality of candidemia in adult surgical patients in Shenyang from 2012 to 2018.
Wei Zhang   +3 more
doaj   +1 more source

A clinicopathological study of candidemia in the elderly.

open access: yesNippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1990
Candidemias were reviewed in 22 elderly patients hospitalized in Yokufukai Geriatric Hospital. Their ages ranged from 62 to 101 years, with a mean age of 81 years. Sixteen patients had either old cerebrovascular disease or senile dementia. In seven patients, synchronous or metachronous bacteremia in the blood culture was associated with the candidemia.
Kawahata, Nobuya   +2 more
openaire   +3 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

open access: yesAdvanced Functional Materials, Volume 36, Issue 24, 23 March 2026.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou   +11 more
wiley   +1 more source

Isolation, RP‐UHPLC‐ESI‐LIT‐Orbitrap‐MS/MS‐Based Metabolic Profiling and Anticandidal Activity of the Root and Leaf Secondary Metabolites of Monotes Kerstingii Gilg (Dipterocarpaceae)

open access: yesChemistry &Biodiversity, Volume 23, Issue 3, March 2026.
This paper describes the isolation and antifungal activity of secondary metabolites from the leaves and roots of Monotes kerstingii. The distribution of these metabolites in the roots and leaves was achieved through comprehensive RP‐UHPLC‐Orbitrap‐MS and MS/MS analysis.
Sorelle Kache Fotsing   +12 more
wiley   +1 more source

Prevalence, Mortality, Antifungal Resistance, and Risk Factors of Candidemia Among Cancer Patients in a Single Center of Southern China: A 10-Year Retrospective Study

open access: yesJournal of Tropical Medicine
Cancer patients are at a high risk of Candida infections, and candidemia may aggravate the prognosis among patients with cancers. To investigate the incidence, mortality, risk factors, and antifungal resistance of candidemia among cancer patients, 100 ...
Limei Chen   +8 more
doaj   +1 more source

T2Candida® to guide antifungal and lengh of treatment of candidemia in a pediatric multivisceral transplant recipient

open access: yesMedical Mycology Case Reports, 2018
A case of 1-year- old male multivisceral transplant recipient with candidemia diagnosed by the T2Candida® test is presented. Optimal management of the candidemia complemented the treatment of the global clinical episode.
Iker Falces-Romero   +8 more
doaj   +1 more source

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