Results 61 to 70 of about 14,635 (217)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie International Edition, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Epidemiology of Candidemia and Fluconazole Resistance in an ICU before and during the COVID-19 Pandemic Era

Antibiotics, 2022
The objectives of this study were to investigate the incidence of candidemia, as well as the factors associated with Candida species distribution and fluconazole resistance, among patients admitted to the intensive care unit (ICU) during the COVID-19 ...
Christina Routsi, Joseph Meletiadis, Efstratia Charitidou, Aikaterini Gkoufa, Stelios Kokkoris, Stavros Karageorgiou, Charalampos Giannopoulos, Despoina Koulenti, Petros Andrikogiannopoulos, Efstathia Perivolioti, Athina Argyropoulou, Ioannis Vasileiadis, Georgia Vrioni, Elizabeth Paramythiotou   +13 more
doaj   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Ocular Manifestations Of Candidemia In Children [PDF]

Pediatric Infectious Disease Journal, 2013
Among 254 patients with candidemia who had a dilated retinal examination, 8 patients (3.2%) were diagnosed with ocular disease resulting in retinal detachment in 2 patients and globe rupture in 1 patient. This study found that ocular candidiasis is an uncommon but serious sight-threatening complication in pediatric patients with candidemia.
Julie L, Fierro, Priya A, Prasad, Brian T, Fisher, Jeffrey S, Gerber, Susan E, Coffin, Thomas J, Walsh, Theoklis E, Zaoutis   +6 more
openaire   +2 more sources

Clinical and Microbiological Characteristics of Candidemia Cases in Saudi Arabia

, 2023
Wala Alkhalifa,1 Hassan Alhawaj,1 Aisha Alamri,2 Fatimah Alturki,1 Mohammed Alshahrani,3 Amani Alnimr1 1Department of Microbiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2Department of Clinical Laboratory ...
Alshahrani M, Alnimr A, Alhawaj H, Alamri A, Alkhalifa W, Alturki F   +5 more
core  

Incidence, clinical characteristics, risk factors and outcomes of patients with mixed Candida/bacterial bloodstream infections: a retrospective study

Annals of Clinical Microbiology and Antimicrobials, 2022
Purpose The mixed Candida/bacterial bloodstream infections (mixed C/B-BSIs) is worthy of particular attention recently, and we analyzed the incidence, co-pathogens, clinical characteristics, risk factors, and outcomes of mixed C/B-BSIs compared with ...
Li Zhong, Zhaohui Dong, Fengqi Liu, Haidong Li, Kankai Tang, Cheng Zheng, Lifang Wang, Kai Zhang, Jiachang Cai, Hongwei Zhou, Wei Cui, Yanqiu Gao, Gensheng Zhang   +12 more
doaj   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 871-889, October 2026.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

Fungal endocarditis in a premature infant complicated by a right atrial mycetoma and inferior vena cava thrombosis [PDF]

, 2009
The incidence of fungal endocarditis in premature infants is on the rise, reported in the last decade secondary to use of central venous lines, the frequent use of broad spectrum antibiotics and neonatal surgical interventions.
Leggiadro, Robert, Nagraj, A., Rajegowda, B., Allapathi, Deepti, Sharma, Jayendra   +4 more
core  

Epidemiology of candidemia in Latin America: a laboratory-based survey.

PLoS ONE, 2013
BackgroundThe epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America.MethodsWe conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin ...
Marcio Nucci, Flavio Queiroz-Telles, Tito Alvarado-Matute, Iris Nora Tiraboschi, Jorge Cortes, Jeannete Zurita, Manuel Guzman-Blanco, Maria Elena Santolaya, Luis Thompson, Jose Sifuentes-Osornio, Juan I Echevarria, Arnaldo L Colombo, Latin American Invasive Mycosis Network   +12 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source