Canine adenovirus type 2 vector generation via I-Sce1-mediated intracellular genome release. [PDF]
PLoS ONE, 2013 When canine adenovirus type 2 (CAdV-2, or also commonly referred to as CAV-2) vectors are injected into the brain parenchyma they preferentially transduce neurons, are capable of efficient axonal transport to afferent regions, and allow transgene ...
Sandy Ibanes, Eric J Kremer
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Transduction of Craniofacial Motoneurons Following Intramuscular Injections of Canine Adenovirus Type-2 (CAV-2) in Rhesus Macaques [PDF]
Frontiers in Neuroanatomy, 2019 Reliable viral vector-mediated transgene expression in primate motoneurons would improve our ability to anatomically and physiologically interrogate motor systems.
Martin O. Bohlen +3 more
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Canine distemper virus and canine adenovirus type-2 infections in neotropical otters (Lontra longicaudis) from Southern Brazil. [PDF]
Braz J Microbiol, 2022 All descriptions of infectious diseases affecting otters were published in the Northern Hemisphere, with no occurrence identified in neotropical otters (Lontra longicaudis). Consequently, a retrospective histopathological study using archival tissue samples from six free-living neotropical otters was done to investigate the possible occurrence of ...
de Mello Zanim Michelazzo M +9 more
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Development of indirect ELISA for the detection of canine adenovirus type 2 antibodies in dog sera. [PDF]
J Vet Sci, 2020 Canine adenovirus type 2 (CAV-2) induces infectious laryngotracheitis in members of the family Canidae, including dogs. To date, no ELISA kits specific for CAV-2 antibody have been commercialized for dogs in Korea.We aimed to develop new indirect enzyme-linked immunosorbent assay (I-ELISA) to perform rapid, accurate serological surveys of CAV-2 in dog ...
Yang DK +6 more
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Feasibility of Canine Adenovirus Type 2 (CAV2) Based Vector for the Locus Coeruleus Optogenetic Activation in Non-Transgenic Rats: Implications for Functional Studies [PDF]
Brain Sciences, 2022 The locus coeruleus norepinephrine (LC-NE) system modulates many visceral and cognitive functions, while LC-NE dysfunction leads to neurological and neurodegenerative conditions such as sleep disorders, depression, ADHD, or Alzheimer’s disease ...
Anna Kabanova +3 more
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Optimized Parameters for Transducing the Locus Coeruleus Using Canine Adenovirus Type 2 (CAV2) Vector in Rats for Chemogenetic Modulation Research [PDF]
Frontiers in Neuroscience, 2021 IntroductionThe locus coeruleus noradrenergic (LC-NA) system is studied for its role in various neurological and psychiatric disorders such as epilepsy and Major Depression Dissorder. Chemogenetics is a powerful technique for specific manipulation of the
Latoya Stevens +7 more
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ISOLATION AND IDENTIFICATION OF CANINE ADENOVIRUS TYPE 2 FROM THE EGYPTIAN DOGS [PDF]
Kafrelsheikh Veterinary Medical Journal, 2015 Canine infectious tracheobronchitis (kennel cough) caused by CAV-2 is one of the most prevalent respiratory infections of dogs. Kennel cough characterized by frequent dry and hacking coughing high morbidity but low mortality rate.
N. F Al-Maria, A. M. Kotb, S. G. Kasem
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Production and purification of non replicative canine adenovirus type 2 derived vectors. [PDF]
J Vis Exp, 2013 Adenovirus (Ad) derived vectors have been widely used for short or long-term gene transfer, both for gene therapy and vaccine applications. Because of the frequent pre-existing immunity against the classically used human adenovirus type 5, canine adenovirus type 2 (CAV2) has been proposed as an alternative vector for human gene transfer.
Szelechowski M +3 more
europepmc +6 more sources
Canine Adenovirus 1 Isolation Bioinformatics Analysis of the Fiber
Frontiers in Cellular and Infection Microbiology, 2022 Canine adenovirus type 1 (CAdV-1) is a double-stranded DNA virus, which is the causative agent of fox encephalitis. The Fiber protein is one of the structural proteins in CAdV-1, which mediates virion binding to the coxsackievirus and adenovirus receptor
Yanzhu Zhu
exaly +3 more sources
Practical guidelines for producing non-replicating canine adenovirus vectors. [PDF]
PLoS ONEAdenovirus vectors have been used for vaccine development, gene therapy, among others, because of their ease of genetic manipulation and high efficiency in delivering and expressing genes in mammalian cells without causing significant cytotoxicity or ...
Denis Omara +16 more
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