Results 81 to 90 of about 3,629 (180)

4‐(5‐Chloro‐3‐(3,4,5‐trimethoxybenzoyl)‐1H‐indol‐1‐yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β‐Catenin Signaling Pathway, and P‐Glycoprotein

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Michela Puxeddu, Rosa Bordone, Claudia Colla, Gabriele Rotili, Antonio Coluccia, Pietro Sciò, Petra Cuřínová, Alessio Nocentini, Claudiu T. Supuran, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Lucia Jimenez, Wolfgang Link, Chiara Bigogno, Giulio Dondio, Martina Barba, Gianluca Canettieri, Romano Silvestri, Giuseppe La Regina   +21 more
wiley   +1 more source

A prospective observational longitudinal study of new-onset seizures and newly diagnosed epilepsy in dogs [PDF]

, 2016
BACKGROUND: Seizures are common in dogs and can be caused by non-epileptic conditions or epilepsy. The clinical course of newly diagnosed epilepsy is sparsely documented.
Berendt, M., Fredsø, N, Sabers, A., Toft, Nils   +3 more
core   +2 more sources

Clinical presentation and management of repetitive circling behaviour in a working cocker spaniel secondary to meningoencephalomyelitis of unknown aetiology

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 3‐year‐old, entire, male cocker spaniel presented for behavioural assessment following a 2.5‐year history of compulsive circling to the right‐hand side. It was previously diagnosed with meningomyelitis of unknown aetiology, following an acute onset of blindness in the left eye and decreased postural reactions.
Emma Gatehouse, Vera Pisco
wiley   +1 more source

Evaluation of a collar‐mounted accelerometer for detecting seizure activity in dogs

Journal of Veterinary Internal Medicine, 2020
Background The majority of dogs with idiopathic epilepsy continue to have seizures despite appropriate treatment. Objectives To assess the use of a commercially available, collar‐mounted accelerometer to detect generalized seizures in dogs.
Karen R. Muñana, Julie A. Nettifee, Emily H. Griffith, Peter J. Early, Nathanael C. Yoder   +4 more
doaj   +1 more source

Idiopathic head tremor in english bulldogs [PDF]

, 2014
Idiopathic head tremor (IHT) syndrome is a recognized but poorly characterized movement disorder in English bulldogs (EBs). The data analyzed were collected via a detailed online questionnaire and video recordings.
Bagley, Deuschl, Forman, Gill, Harcourt-Brown, Herrtage, Jokinen, Lahunta, Lahunta, Leegwater-Kim, Louis, Meyers, Nakahata, Packer, Penderis, Ramsey, Teive, Tremor, myoclonus, focal dystonias, and tics, Wolf, Woods   +19 more
core   +1 more source

From Molecule to Meaning: Neuronopathic Biomarkers and Clinical Relevance in GM1

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT GM1 gangliosidosis is a rare, progressively neurodegenerative lysosomal storage disorder characterized by profound central nervous system involvement and substantial clinical heterogeneity. The development of reliable biomarkers is essential for tracking disease progression, stratifying patients, and advancing clinical trial readiness. Primary
Krista Casazza, Roberto Giugliani, Debra S. Regier, Jeanine Jarnes   +3 more
wiley   +1 more source

French Bulldog Diagnosed With a Suspected Brain Tumor Shortly After Treatment for Spinal Arachnoid Diverticulum

Case Reports in Veterinary Medicine, Volume 2026, Issue 1, 2026.
An 8‐year‐ and 8‐month‐old spayed female 8.8‐kg French bulldog presented with a 4‐month history of progressive deterioration, followed by paresis of both pelvic limbs. Orthopedic examination revealed no abnormalities. Neurological examination revealed no findings suggestive of brain dysfunction.
Yuya Nakamoto, Kyosuke Hidari, Mei Matsuo, Miwa Nakamoto, Lipi Buch   +4 more
wiley   +1 more source

Diagnostic Utility of Wireless Video-Electroencephalography in Unsedated Dogs [PDF]

, 2017
Background: Poor agreement between observers on whether an unusual event is a seizure drives the need for a specific diagnostic tool provided by video-electroencephalography (video-EEG) in human pediatric epileptology.
Cortez, M. A., Fischer, A., James, F. M. K., Jokinen, T. S., Lohi, H., Monteith, G., Sanders, S., Wielaender, F.   +7 more
core   +1 more source

Long‐term outcome of presumptive idiopathic hyperesthesia syndrome in a dog treated with fluoxetine

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 9‐year‐old, 10 kg, male, neutered, mixed‐breed dog was evaluated for a history of daily episodes of thoracic and lumbar hair horripilation with potential hypersensitivity and discomfort for at least 1 year, as reported by the owner. Dermatological disease was ruled out.
Claudia Pauciulo, Antonella Gallucci
wiley   +1 more source

Re-evaluating the placebo response in recent canine dietary epilepsy trials

BMC Veterinary Research
The placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can significantly influence the efficacy evaluation of new treatments.
Teresa Schmidt, Nina Meyerhoff, Sebastian Meller, Friederike Twele, Marios Charalambous, Benjamin A. Berk, Tsz H. Law, Rowena M. A. Packer, Brian Zanghi, Yuanlong Pan, Andrea Fischer, Holger A. Volk   +11 more
doaj   +1 more source