Canine Influenza Virus is Mildly Restricted by Canine Tetherin Protein [PDF]
Viruses, 2018 Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells.
Yun Zheng +8 more
doaj +5 more sources
Spread of Canine Influenza A(H3N2) Virus, United States [PDF]
Emerging Infectious Diseases, 2017 A canine influenza A(H3N2) virus emerged in the United States in February–March 2015, causing respiratory disease in dogs. The virus had previously been circulating among dogs in Asia, where it originated through the transfer of an avian-origin influenza
Ian E.H. Voorhees +12 more
doaj +5 more sources
Identification of the functional domains of canine tetherin in antiviral activity against canine influenza virus [PDF]
Frontiers in Veterinary ScienceCanine influenza virus (CIV) is a respiratory pathogen that causes fever, coughing, and sneezing in dogs and is continuously circulating in canine populations. Tetherin is an antiviral host restriction factor mediated by interferon, capable of inhibiting
Jiajun Ou +9 more
doaj +4 more sources
Emergence of a novel reassortant H3N6 canine influenza virus [PDF]
Frontiers in Microbiology, 2023 Although the natural hosts of avian influenza viruses (AIVs) are wild birds, multiple subtypes of AIVs have established epidemics in numerous mammals due to their cross-species spillover. Replication and evolution in intermedia mammalian hosts may facilitate AIV adaptation in humans.
Weiwei Guo, Hualan Chen
exaly +5 more sources
Host-Adaptive Signatures of H3N2 Influenza Virus in Canine
Frontiers in Veterinary Science, 2021 Wild aquatic birds are the primary natural reservoir of influenza A viruses (IAVs), although a small number of viruses can spill over to mammals and circulate.
Xueyun Li +6 more
doaj +3 more sources
Negative regulation of reassortant canine influenza virus replication and key site identification in porcine and ferret bronchial epithelial cell lines [PDF]
VirulenceThe segmented nature and high mutability of the influenza virus RNA genome facilitate rapid mutation and reassortment, allowing the virus to breach host barriers and migrate between different species, potentially leading to unpredictable influenza ...
Jingjing Guo +13 more
doaj +2 more sources
Genetic characterization of an H3N2 canine influenza virus strain in China in 2023—acquisition of novel human-like amino acid substitutions [PDF]
Frontiers in Veterinary ScienceAround 2005, influenza A virus (IAV) once again crossed species barriers and established a stable lineage within canine populations. Currently, avian-origin H3N2 canine influenza virus (CIV) is the only strain of influenza that is stably circulating in ...
Sihan Li +4 more
doaj +2 more sources
Identification of Two Isoforms of Canine Tetherin in Domestic Dogs and Characterization of Their Antiviral Activity against Canine Influenza Virus [PDF]
Viruses, 2023 Canine influenza virus (CIV) significantly threatens the canine population and public health. Tetherin, an innate immune factor, plays an important role in the defense against pathogen invasion and has been discovered to restrict the release of various ...
Liang Xu +9 more
doaj +2 more sources
The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly [PDF]
Emerging Microbes and InfectionsAvian influenza viruses (AIVs) are the origin of multiple mammal influenza viruses. The genetic determinants of AIVs adapted to humans have been widely elucidated, however, the molecular mechanism of cross-species transmission and adaptation of AIVs to ...
Xueyun Li +8 more
doaj +2 more sources
Intranasal NS1-truncated live attenuated canine influenza vaccine confers superior protection compared to inactivated vaccine in beagles [PDF]
Veterinary ResearchCanine influenza virus (CIV) H3N2 continues to circulate among companion animals, posing a zoonotic risk due to its potential for cross-species transmission.
Jaehyun Hwang +15 more
doaj +2 more sources