Results 51 to 60 of about 30,067 (209)

A bivalent live-attenuated influenza vaccine for the control and prevention of H3N8 and H3N2 canine influenza viruses [PDF]

, 2017
Canine influenza viruses (CIVs) cause a contagious respiratory disease in dogs. CIV subtypes include H3N8, which originated from the transfer of H3N8 equine influenza virus (EIV) to dogs; and the H3N2, which is an avian-origin virus adapted to infect ...
Martínez-Sobrido, Luis, Murcia, Pablo R., Nogales, Aitor, Parrish, Colin, Rodriguez, Laura   +4 more
core   +1 more source

A novel reassortant canine H3N1 influenza virus between pandemic H1N1 and canine H3N2 influenza viruses in Korea

Journal of General Virology, 2012
During recent canine influenza surveillance in South Korea, a novel H3N1 canine influenza virus (CIV) that is a putative reassortant between pandemic H1N1 2009 and H3N2 CIVs was isolated. Genetic analysis of eight genes of the influenza virus revealed that the novel H3N1 isolate presented high similarities (99.1–99.9 %) to pandemic influenza H1N1 ...
Daesub, Song, Hyoung-Joon, Moon, Dong-Jun, An, Hye-Young, Jeoung, Hyekwon, Kim, Min-Joo, Yeom, Minki, Hong, Jeong-Hyun, Nam, Seong-Jun, Park, Bong-Kyun, Park, Jin-Sik, Oh, Manki, Song, Robert G, Webster, Jeong-Ki, Kim, Bo-Kyu, Kang   +14 more
openaire   +2 more sources

Distinct susceptibility and applicability of MDCK derivatives for influenza virus research. [PDF]

PLoS ONE, 2017
Madin-Darby Canine Kidney (MDCK) cells are widely utilized as a substrate for influenza virus isolation and propagation due to the high yields of virus.
Shih-Chao Lin, Matthew A Kappes, Mei-Chun Chen, Chi-Chen Lin, Tony T Wang   +4 more
doaj   +1 more source

Interferon-lambda: A potent regulator of intestinal viral infections [PDF]

, 2017
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
core   +3 more sources

Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor

Molecules, 2019
Influenza A viruses leading to infectious respiratory diseases cause seasonal epidemics and sometimes periodic global pandemics. Viral polymerase is an attractive target in inhibiting viral replication, and 4′-ethynyladenosine, which has been ...
Toshifumi Takeuchi, Nongluk Sriwilaijaroen, Ayako Sakuraba, Ei Hayashi, Shinji Kamisuki, Yasuo Suzuki, Hiroshi Ohrui, Fumio Sugawara   +7 more
doaj   +1 more source

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus [PDF]

, 2018
Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against ...
Andrew V Stachulski, Brian M Eklov, Chandrakala Pidathala, Eleanor C Row, Giuseppe Belardo, J Edward Semple, Jean-Francois Rossignol, La Frazia S, M Gabriella Santoro, Mazhar Iqbal, Neil G Berry, Paul M O'Neill, Podlogar BL, Rossignol JF, Rossignol JF, Sara Piacentini, Sarah A Allman, Simone La Frazia   +17 more
core   +1 more source

Intranasal vaccination with an engineered influenza virus expressing the receptor binding subdomain of botulinum neurotoxin provides protective immunity against botulism and influenza

Frontiers in Immunology, 2015
Influenza virus is a negative, segmented RNA virus without DNA intermediate. This makes it safer as a vaccine delivery vector than most DNA viruses that have potential to integrate their genetic elements into host genomes.
Junwei eLi, Diana eDiaz-Arévalo, Yanping eChen, Mingtao eZeng   +3 more
doaj   +1 more source

Canine Influenza Virus Replicates in Alveolar Macrophages and Induces TNF-α [PDF]

Veterinary Pathology, 2009
Canine influenza virus (CIV) is a recently emergent pathogen of dogs that has caused highly contagious respiratory disease in racing Greyhounds, pet dogs, and shelter animals. Initial characterizations of CIV-induced respiratory disease suggested alveolar macrophages may be susceptible to virus infection.
J R, Powe, W L, Castleman
openaire   +2 more sources

Generation of influenza virus from avian cells infected by Salmonella carrying the viral genome. [PDF]

PLoS ONE, 2015
Domestic poultry serve as intermediates for transmission of influenza A virus from the wild aquatic bird reservoir to humans, resulting in influenza outbreaks in poultry and potential epidemics/pandemics among human beings.
Xiangmin Zhang, Wei Kong, Soo-Young Wanda, Wei Xin, Praveen Alamuri, Roy Curtiss   +5 more
doaj   +1 more source

Canine Influenza Virus A(H3N2) Clade with Antigenic Variation, China, 2016-2017. [PDF]

Emerg Infect Dis, 2019
During 2012-2017, we collected throat swabs from dogs in China to characterize canine influenza virus (CIV) A(H3N2) isolates. A new antigenically and genetically distinct CIV H3N2 clade possessing mutations associated with mammalian adaptation emerged in 2016 and replaced previously circulating strains.
Lyu Y, Song S, Zhou L, Bing G, Wang Q, Sun H, Chen M, Hu J, Wang M, Sun H, Pu J, Xia Z, Liu J, Sun Y.   +13 more
europepmc   +5 more sources