Results 1 to 10 of about 17,677 (181)

Generation of a Reassortant Influenza A Subtype H3N2 Virus Expressing Gaussia Luciferase [PDF]

Viruses, 2019
Reporter influenza A viruses (IAVs) carrying fluorescent or luminescent genes provide a powerful tool for both basic and translational research. Most reporter IAVs are based on the backbone of either subtype H1N1 viruses, A/Puerto Rico/8/1934 (PR8) or A ...
Lin Wang, Qinghua Cui, Xiujuan Zhao, Ping Li, Yanyan Wang, Lijun Rong, Ruikun Du   +6 more
doaj   +3 more sources

A Sequence-Based Update on Amino Acid Substitutions in Influenza Polymerase Acidic Protein in Europe That Alter Baloxavir Susceptibility From 2009 to 2025. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background Influenza causes 650,000 deaths, 3–5 million hospitalizations, and 1 billion cases worldwide each year. There is a limited repertoire of antivirals available to tackle this burden, highlighting the risk of developing resistance to current drugs.
Martín-Toribio A, Inchausti-Moya I, Toquero-Asensio M, García-Díaz S, Sanchez-Martinez J, Rodriguez-Crespo C, Galindo-Carretero S, Iglesia-Aparicio R, Lopez-Gonzalo C, Antón-Contreras A, Rojo-Rello S, Dominguez-Gil M, Hernández M, Eiros JM, Nistal-Villan E, Sanz-Muñoz I.   +15 more
europepmc   +2 more sources

Prior immunity to seasonal influenza A(H3N2) virus confers varying levels of cross-protection against challenge with clade 2.3.4.4b A(H5N1), A(H7N9), or A(H9N2) virus in a ferret model [PDF]

Microbiology Spectrum
Evaluating how prior immunity to seasonal influenza viruses influences subsequent zoonotic influenza A virus (IAV) infection in animal models is critical for pandemic preparedness.
Xiangjie Sun, Jessica A. Belser, Zhu-Nan Li, Feng Liu, Nicole Brock, Joanna A. Pulit-Penaloza, Troy J. Kieran, Claudia Pappas, Hui Zeng, Jessie C. Chang, Paul J. Carney, Brandon L. Bradley-Ferrell, James Stevens, Min Z. Levine, Terrence M. Tumpey, Taronna R. Maines   +15 more
doaj   +2 more sources

Cats are more susceptible to the prevalent H3 subtype influenza viruses than dogs [PDF]

Virulence
Recent reports have highlighted the increasing frequency of influenza A virus (IAV) spillover events from other species to dogs and cats. IAV, particularly the H3 subtype, exhibits a broad host range and a propensity for interspecies transmission, as ...
Jie Deng, Chunhui Ma, Junting Yu, Bo Chen, Shoujun Li, Pei Zhou   +5 more
doaj   +2 more sources

Increased levels of α2-3- and α2-6-linked sialic acids during airway inflammation govern influenza A binding to peripheral airway mucins in a subtype-dependent manner [PDF]

Frontiers in Immunology
BackgroundInfluenza infection increases the risk of pneumonia and respiratory failure in chronic obstructive pulmonary disease (COPD) and mucins play an important role in pulmonary host defense.MethodsLower airway mucins were obtained from long-term ...
John Benktander, Macarena Paz Quintana Hayashi, Rickard Nordén, Rickard Nordén, Lisa Pettersson, Magnus Paulsson, Magnus Paulsson, Anders Lindén, Anders Lindén, Sara K. Lindén   +9 more
doaj   +2 more sources

Emergence and Evolution of Novel Canine-Avian Reassortant H3N2 Influenza A Viruses in Duck in Leizhou Peninsula, China

Frontiers in Microbiology, 2022
Avian-to-mammal transmission and mammalian adaptation of avian influenza virus (AIV) are threats to public health and of great concern. The H3 subtype of influenza virus has low pathogenicity and is widely distributed in humans, canines, equines and ...
Qiucheng Yao, Wenhong Mai, Yuexiao Lian, Mengdi Zhang, Qiang Yao, Caiyun Huang, Ye Ge, Zhihui Zhao   +7 more
doaj   +1 more source

Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults [PDF]

Antimicrobial Agents and Chemotherapy, 1986
In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine treatment (200 mg/day for 5 days) was associated with significant reductions in nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (mean, 37 h shorter), and systemic ...
F G, Hayden, A S, Monto
openaire   +2 more sources

Genetic Diversity and Evolutionary Kinetics of Influenza A Virus H3N2 Subtypes Circulating in Riyadh, Saudi Arabia

Vaccines, 2023
Presence of a large foreign workforce and the annual gathering of people for pilgrimage from around the globe have significantly contributed to the emergence and diversity of respiratory viruses in Saudi Arabia. Here, we report the sequence and phylogenetic analysis of the H3N2 subtype of influenza A virus (IAV) in clinical samples collected from ...
Gani Asa Dudin, Ibrahim M. Aziz, Rasha M. Alzayed, Anwar Ahmed, Tajamul Hussain, Ali M. Somily, Muslim M. Alsaadi, Fahad N. Almajhdi   +7 more
openaire   +3 more sources

Estimating Influenza-associated Mortality in Korea: The 2009-2016 Seasons [PDF]

Journal of Preventive Medicine and Public Health, 2019
Objectives Estimating influenza-associated mortality is important since seasonal influenza affects persons of all ages, causing severe illness or death.
Kwan Hong, Sangho Sohn, Byung Chul Chun
doaj   +1 more source

Evaluation of Next-Generation H3 Influenza Vaccines in Ferrets Pre-Immune to Historical H3N2 Viruses

Frontiers in Immunology, 2021
Each person has a unique immune history to past influenza virus infections. Exposure to influenza viruses early in life establishes memory B cell populations that influence future immune responses to influenza vaccination.
James D. Allen, Ted M. Ross, Ted M. Ross
doaj   +1 more source