Results 41 to 50 of about 17,677 (181)

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, Volume 7, Issue 4, August 2026.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

The Dual Role of Preexisting Immunity in Influenza: Protective Recall Versus Constraint of Novel Responses

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Preexisting immunity to influenza confers rapid protection against antigenically matched viruses but can also constrain responses to drifted variants. This review asks when and why prior infection or vaccination is protective versus detrimental, and which biological mechanisms—epitope masking by circulating antibody, inhibitory FcγRIIb ...
Annette Fox, Ziheng Zhu, Stephany Sánchez‐Ovando   +2 more
wiley   +1 more source

Verification of the Combimatrix influenza detection assay for the detection of influenza A subtype during the 2007–2008 influenza season in Toronto, Canada

Virology Journal, 2009
The increase in adamantine resistance in influenza A (H3N2) and the emergence of oseltamivir resistance in influenza A (H1N1) has necessitated the use of rapid methodologies to detect influenza subtype.
Blair Joanne, Eshaghi AliReza, Yeung Rani, Lombos Ernesto, Bolotin Shelly, Drews Steven J   +5 more
doaj   +1 more source

An Eight-Segment Swine Influenza Virus Harboring H1 and H3 Hemagglutinins Is Attenuated and Protective against H1N1 and H3N2 Subtypes in Pigs [PDF]

Journal of Virology, 2013
ABSTRACT Swine influenza virus (SIV) infections continue to cause production losses in the agricultural industry in addition to being a human public health concern. The primary method of controlling SIV is through vaccination.
Aleksandar, Masic, Hyun-Mi, Pyo, Shawn, Babiuk, Yan, Zhou   +3 more
openaire   +2 more sources

Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley   +1 more source

Temporal patterns of influenza A subtypes and B lineages across age in a subtropical city, during pre-pandemic, pandemic, and post-pandemic seasons

BMC Infectious Diseases, 2019
Background Seasonal patterns of influenza A subtypes and B lineages in tropical/subtropical regions across age have remained to be explored. The impact of the 2009 H1N1 pandemic on seasonal influenza activity have not been well understood.
Linlin Zhou, Huiping Yang, Yu Kuang, Tianshu Li, Jianan Xu, Shuang Li, Ting Huang, Chuan Wang, Wanyi Li, Mingyuan Li, Shusen He, Ming Pan   +11 more
doaj   +1 more source

Development of reverse-transcription loop-mediated isothermal amplification assays for point-of-care testing of human influenza virus subtypes H1N1 and H3N2

Genomics & Informatics, 2022
Influenza A virus (IAV) is the most widespread pathogen causing human respiratory infections. Although polymerase chain reaction (PCR)–based methods are currently the most commonly used tools for IAV detection, PCR is not ideal for point-of-care testing. In this study, we aimed to develop a more rapid and sensitive method than PCR-based tools to detect
Ji-Soo Kang, Mi-Ran Seo, Yeun-Jun Chung
openaire   +2 more sources

Effectiveness of Influenza Vaccines and Duration of Protection Against Hospitalisation During the 2024/25 Season in Northern Ireland, UK

Influenza and Other Respiratory Viruses, Volume 20, Issue 8, August 2026.
ABSTRACT Background Seasonal influenza causes substantial morbidity and hospitalisation each year. We estimated influenza vaccine effectiveness (VE) against laboratory‐confirmed influenza‐associated hospitalisation among patients in Northern Ireland (NI) during the 2024/25 influenza season.
Magda Bucholc, Siobhán Murphy, Mark G. O'Doherty, Suzanne Wilton, Emma Dickson, Declan T. Bradley   +5 more
wiley   +1 more source

Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

eLife
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected individuals, but the
Amanda C Perofsky, John Huddleston, Chelsea L Hansen, John R Barnes, Thomas Rowe, Xiyan Xu, Rebecca Kondor, David E Wentworth, Nicola Lewis, Lynne Whittaker, Burcu Ermetal, Ruth Harvey, Monica Galiano, Rodney Stuart Daniels, John W McCauley, Seiichiro Fujisaki, Kazuya Nakamura, Noriko Kishida, Shinji Watanabe, Hideki Hasegawa, Sheena G Sullivan, Ian G Barr, Kanta Subbarao, Florian Krammer, Trevor Bedford, Cécile Viboud   +25 more
doaj   +1 more source

Similar severity of influenza primary and re-infections in pre-school children requiring outpatient treatment due to febrile acute respiratory illness: prospective, multicentre surveillance study (2013–2015)

BMC Infectious Diseases, 2022
Background Influenza virus infections in immunologically naïve children (primary infection) may be more severe than in children with re-infections who are already immunologically primed.
Andrea Streng, Christiane Prifert, Benedikt Weissbrich, Andreas Sauerbrei, Andi Krumbholz, Ruprecht Schmidt-Ott, Johannes G. Liese   +6 more
doaj   +1 more source