Results 41 to 50 of about 18,035 (133)

Verification of the Combimatrix influenza detection assay for the detection of influenza A subtype during the 2007–2008 influenza season in Toronto, Canada

Virology Journal, 2009
The increase in adamantine resistance in influenza A (H3N2) and the emergence of oseltamivir resistance in influenza A (H1N1) has necessitated the use of rapid methodologies to detect influenza subtype.
Blair Joanne, Eshaghi AliReza, Yeung Rani, Lombos Ernesto, Bolotin Shelly, Drews Steven J   +5 more
doaj   +1 more source

Some Exposure for Influenza Hemagglutinin Interface Antibodies

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Influenza viruses are a constant threat to human health. Current vaccines often confer low to moderate protection against infection with seasonal viruses and little‐to‐no protection against pandemic viruses. Improved vaccines are needed. These vaccines will need to reliably elicit antibodies to conserved sites that are broadly protective.
Kevin R. McCarthy
wiley   +1 more source

Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

eLife
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected individuals, but the
Amanda C Perofsky, John Huddleston, Chelsea L Hansen, John R Barnes, Thomas Rowe, Xiyan Xu, Rebecca Kondor, David E Wentworth, Nicola Lewis, Lynne Whittaker, Burcu Ermetal, Ruth Harvey, Monica Galiano, Rodney Stuart Daniels, John W McCauley, Seiichiro Fujisaki, Kazuya Nakamura, Noriko Kishida, Shinji Watanabe, Hideki Hasegawa, Sheena G Sullivan, Ian G Barr, Kanta Subbarao, Florian Krammer, Trevor Bedford, Cécile Viboud   +25 more
doaj   +1 more source

Similar severity of influenza primary and re-infections in pre-school children requiring outpatient treatment due to febrile acute respiratory illness: prospective, multicentre surveillance study (2013–2015)

BMC Infectious Diseases, 2022
Background Influenza virus infections in immunologically naïve children (primary infection) may be more severe than in children with re-infections who are already immunologically primed.
Andrea Streng, Christiane Prifert, Benedikt Weissbrich, Andreas Sauerbrei, Andi Krumbholz, Ruprecht Schmidt-Ott, Johannes G. Liese   +6 more
doaj   +1 more source

What Antibody Repertoires See: Structural and Immunogenetic Insights Into Influenza A Virus Hemagglutinin Recognition

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Human infection with or vaccination against influenza A virus has been one of the most informative systems for understanding how human antibody repertoires recognize viral glycoproteins. Decades of antibody isolation, repertoire sequencing, lineage tracing, serology, viral antigenic evolution, and structural biology have shown that antibody ...
Bruno Bonnettaz, Goran Bajic
wiley   +1 more source

Global patterns in seasonal activity of influenza A/H3N2, A/H1N1, and B from 1997 to 2005: viral coexistence and latitudinal gradients.

PLoS ONE, 2007
Despite a mass of research on the epidemiology of seasonal influenza, overall patterns of infection have not been fully described on broad geographic scales and for specific types and subtypes of the influenza virus.
Brian S Finkelman, Cécile Viboud, Katia Koelle, Matthew J Ferrari, Nita Bharti, Bryan T Grenfell   +5 more
doaj   +1 more source

Whole-genome sequences of influenza A(H3N2) viruses isolated from Brazilian patients with mild illness during the 2014 season

Memorias do Instituto Oswaldo Cruz, 2015
The influenza A(H3N2) virus has circulated worldwide for almost five decades and is the dominant subtype in most seasonal influenza epidemics, as occurred in the 2014 season in South America.
Paola Cristina Resende, Fernando Couto Motta/+, Priscila Silva Born, Milene Miranda, Marilda M Siqueira   +4 more
doaj   +1 more source

Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1

Emerging Infectious Diseases, 2007
Changes in influenza viruses require regular reformulation of strain-specific influenza vaccines. Vaccines based on conserved antigens provide broader protection. Influenza matrix protein 2 (M2) is highly conserved across influenza A subtypes.
Stephen Mark Tompkins, Zi-Shan Zhao, Chia-Yun Lo, Julia A. Misplon, Teresa Liu, Zhiping Ye, Robert J. Hogan, Zhengqi Wu, Kimberly A. Benton, Terrence M. Tumpey, Suzanne L. Epstein   +10 more
doaj   +1 more source

A Cluster of Influenza A(H3N2) Viruses in 2024 From Tasmania, Australia, With Reduced Susceptibility to Baloxavir

Influenza and Other Respiratory Viruses, Volume 20, Issue 9, September 2026.
ABSTRACT The emergence of viruses with reduced susceptibility to antivirals poses an ongoing risk which could limit their effectiveness. Here we report a cluster of A(H3N2) viruses detected in Tasmania, Australia, with a PA gene mutation A37T that showed mild reductions in susceptibility in vitro to baloxavir (3.47‐ to 16.33‐fold increased EC50) when ...
Saira Hussain, Charmaine Chia, Ashwin Muraleetharan, Yi‐Mo Deng, Xiaomin Dong, Presa Chanthalavanh, Emi Takashita, Clyde Dapat, Jessica E. Miller, Heidi Peck, Raphael T. C. Lee, Jan Williamson, Louise Cooley, Sebastian Maurer‐Stroh, Ian G. Barr   +14 more
wiley   +1 more source

Development of the cell-ELISA test for the subtype identification of circulating influenza A(H1) and A(H3) viruses

Microbiology Independent Research Journal, 2015
The sensitive version of cell-ELISA was developed for the subtype-specific differentiation of current influenza A(H1N1)pdm09 and A(H3N2) viruses that are circulating in the human population. This method is based on the estimation of virus reproduction in
Vera Krivitskaya, Evgeniy Sorokin, Tatyana Tsareva, Ekaterina Petrova, Nadezhda Konovalova, Maria Pisareva, Zhanna Buzitskaya, Tatyana Smirnova, Anna Sominina   +8 more
doaj   +1 more source