Results 61 to 70 of about 136,671,996 (217)

Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1

Emerging Infectious Diseases, 2007
Changes in influenza viruses require regular reformulation of strain-specific influenza vaccines. Vaccines based on conserved antigens provide broader protection. Influenza matrix protein 2 (M2) is highly conserved across influenza A subtypes.
Stephen Mark Tompkins, Zi-Shan Zhao, Chia-Yun Lo, Julia A. Misplon, Teresa Liu, Zhiping Ye, Robert J. Hogan, Zhengqi Wu, Kimberly A. Benton, Terrence M. Tumpey, Suzanne L. Epstein   +10 more
doaj   +1 more source

An Eight-Segment Swine Influenza Virus Harboring H1 and H3 Hemagglutinins Is Attenuated and Protective against H1N1 and H3N2 Subtypes in Pigs [PDF]

Journal of Virology, 2013
ABSTRACT Swine influenza virus (SIV) infections continue to cause production losses in the agricultural industry in addition to being a human public health concern. The primary method of controlling SIV is through vaccination.
Aleksandar, Masic, Hyun-Mi, Pyo, Shawn, Babiuk, Yan, Zhou   +3 more
openaire   +2 more sources

Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

eLife
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected individuals, but the
Amanda C Perofsky, John Huddleston, Chelsea L Hansen, John R Barnes, Thomas Rowe, Xiyan Xu, Rebecca Kondor, David E Wentworth, Nicola Lewis, Lynne Whittaker, Burcu Ermetal, Ruth Harvey, Monica Galiano, Rodney Stuart Daniels, John W McCauley, Seiichiro Fujisaki, Kazuya Nakamura, Noriko Kishida, Shinji Watanabe, Hideki Hasegawa, Sheena G Sullivan, Ian G Barr, Kanta Subbarao, Florian Krammer, Trevor Bedford, Cécile Viboud   +25 more
doaj   +1 more source

Transport–Reaction–Signal Coupling in Lateral Flow Assays for Next‐Generation Point‐of‐Care Diagnostics

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Lateral flow assays are evolving into interdisciplinary, system‐level sensing platforms. Recent innovations are deconstructed through coupled phases of mass transfer, reaction, and signal transduction, revealing interdependence across porous materials, interfacial chemistry, nanolabels, readout devices, and data‐enabled analysis.
Yan Pan, Yuewei Li, Chao Mi, Zhengwen Yang, Lana McClements, Steven J. Langford, Jiayan Liao   +6 more
wiley   +1 more source

Global patterns in seasonal activity of influenza A/H3N2, A/H1N1, and B from 1997 to 2005: viral coexistence and latitudinal gradients.

PLoS ONE, 2007
Despite a mass of research on the epidemiology of seasonal influenza, overall patterns of infection have not been fully described on broad geographic scales and for specific types and subtypes of the influenza virus.
Brian S Finkelman, Cécile Viboud, Katia Koelle, Matthew J Ferrari, Nita Bharti, Bryan T Grenfell   +5 more
doaj   +1 more source

Whole-genome sequences of influenza A(H3N2) viruses isolated from Brazilian patients with mild illness during the 2014 season

Memorias do Instituto Oswaldo Cruz, 2015
The influenza A(H3N2) virus has circulated worldwide for almost five decades and is the dominant subtype in most seasonal influenza epidemics, as occurred in the 2014 season in South America.
Paola Cristina Resende, Fernando Couto Motta/+, Priscila Silva Born, Milene Miranda, Marilda M Siqueira   +4 more
doaj   +1 more source

Similar severity of influenza primary and re-infections in pre-school children requiring outpatient treatment due to febrile acute respiratory illness: prospective, multicentre surveillance study (2013–2015)

BMC Infectious Diseases, 2022
Background Influenza virus infections in immunologically naïve children (primary infection) may be more severe than in children with re-infections who are already immunologically primed.
Andrea Streng, Christiane Prifert, Benedikt Weissbrich, Andreas Sauerbrei, Andi Krumbholz, Ruprecht Schmidt-Ott, Johannes G. Liese   +6 more
doaj   +1 more source

Dual Antiviral and Immunomodulatory Effects of Phytochemicals in Influenza A Virus Infection: Targeting Key Host Signaling Pathways

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Influenza A virus modulates host innate immune pathways, including TLR, RIG‐I, MAPK, and NF‐κB signaling, to support replication and drive inflammatory pathology. Plant‐derived phytocompounds target these interconnected pathways, offering a potential host‐directed immunomodulatory approach complementary to conventional antivirals.
Dibakar Chowdhury, Hillary A. Vanderven, Phurpa Wangchuk, Subir Sarker   +3 more
wiley   +1 more source

Anti‐idiotypic antibodies as molecular mimics of conserved influenza hemagglutinin epitopes

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Broadly neutralizing antibodies (bNAbs) provide insights for developing universal influenza vaccines through their ability to neutralize diverse viral strains. However, designing antigens that reliably elicit bNAb responses remains challenging due to the difficulty in targeting conserved epitopes with a single antigen.
Hiroshi Itou, Kaori Sano, Akira Ainai, Kazushige Otsuki, Toshikazu Inoue, Takuya Hemmi, Hideki Hasegawa, Tadaki Suzuki   +7 more
wiley   +1 more source

Duration and severity of asthma‐like episodes in young children vary by viral and bacterial triggers

Pediatric Allergy and Immunology, Volume 37, Issue 10, October 2026.
This study investigates how specific viral and bacterial triggers and age are associated with the duration and severity of asthma‐like episodes in children aged 0–3 years. Rhinovirus, particularly rhinovirus C, and the bacterial pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were associated with longer episode ...
Julie Nyholm Kyvsgaard, Jonathan Thorsen, Signe Kjeldgaard Jensen, Tamo Sultan, Nicklas Brustad, Casper‐Emil Tingskov Pedersen, Anton Kjellberg, Thea K. Fischer, Karen A. Krogfelt, Nilo Vahman, James E. Gern, Ann‐Marie Malby Schoos, Klaus Bønnelykke, Bo Lund Chawes, Jakob Stokholm   +14 more
wiley   +1 more source