Results 131 to 140 of about 59,439 (317)

Antitumoral effects of cannabis in Notch1‐mutated T‐cell acute lymphoblastic leukemia

Cancer Communications, 2023
Elazar Besser, Anat Gelfand, Gil Moshe Lewitus, Hila Novak‐Kotzer, Shiri Procaccia, Paula Berman, Igal Louria‐Hayon, Inbar Shreiber‐Livne, Yishai Ofran, David Meiri   +9 more
doaj   +1 more source

CsCBDAS2-Driven Enhancement of Cannabinoid Biosynthetic Genes Using a High-Efficiency Transient Transformation System in Cannabis sativa ‘Cheungsam’

Plants
Cannabis sativa produces pharmacologically valuable cannabinoids. In this study, we developed and optimized a transient transformation system using Cannabis sativa ‘Cheungsam’ to facilitate gene functional analysis.
Sang-Cheol Baek, Sang-Yoon Jeon, Bo-Hyun Byun, Da-Hoon Kim, Ga-Ram Yu, Hyuck Kim, Dong-Woo Lim   +6 more
doaj   +1 more source

Determining the impact of cannabis use on tobacco cessation: Results from a prospective non‐randomized tobacco treatment trial

Addiction, EarlyView.
Abstract Background and aims Tobacco‐cannabis co‐use is associated with increased psychosocial and health harms; however, the treatment literature assessing the impact of co‐use has been mixed and suffers from critical limitations. To date, no prospective studies have evaluated the degree to which cannabis co‐use affects tobacco cessation, nor are ...
Erin A. McClure, Nathaniel Baker, Rachel L. Tomko, Kyle J. Walters, Elizabeth Chapman, Matthew J. Carpenter, Kevin M. Gray   +6 more
wiley   +1 more source

Cannabidiol-Loaded Retinal Organoid-Derived Extracellular Vesicles Protect Oxidatively Stressed ARPE-19 Cells

Biomedicines
Background/Objectives: Age-related macular degeneration (AMD) is the third leading cause of irreversible blindness in elderly individuals aged over 50 years old. Oxidative stress plays a crucial role in the etiopathogenesis of multifactorial AMD disease.
Peggy Arthur, Sangeetha Kandoi, Anil Kalvala, Breana Boirie, Aakash Nathani, Mounika Aare, Santanu Bhattacharya, Tanmay Kulkarni, Li Sun, Deepak A. Lamba, Yan Li, Mandip Singh   +11 more
doaj   +1 more source

BIOCHEMICAL PROFILE OF BIOTIN‐ANANDAMIDE, A NOVEL TOOL FOR THE VISUALIZATION OF ANANDAMIDE ACCUMULATION

, 2008
Anandamide (arachidonoylethanolamide, AEA) acts as endogenous agonist of both cannabinoidand vanilloid receptors. During the last two decades, its metabolic pathways and biologicalactivity have been extensively investigated and relatively well ...
Maccarrone M, ODDI, Sergio, Fezza F, RAPINO, CINZIA, De Simone C, Finazzi‐Agrò A., DAINESE, Enrico, Pasquariello N   +7 more
core  

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Cannabinoid‐Induced Hyperphagia is Mediated by Increased Meal Frequency and the Orexin‐1 Receptor in Male Rats

Pharmacology Research & Perspectives
Exogenous cannabinoids have long been known to promote eating. However, the underlying mechanisms have not been completely elucidated, which is critical to understanding their utility.
Magen N. Lord, Grace C. Madu, Ana L. Loera‐Lopez, Alexander P. Aaron, Jessica Lin, Emily E. Noble   +5 more
doaj   +1 more source

Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics

Frontiers in Molecular Neuroscience
The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new therapies. New migraine therapeutics are needed to address the current deficiencies that exist in the efficacy and adherence rate of ...
Kofi Frimpong-Manson, Yuma T. Ortiz, Lance R. McMahon, Jenny L. Wilkerson   +3 more
doaj   +1 more source

The association between sleep disturbance and stimulant use: A cross‐lagged examination

Addiction, EarlyView.
Abstract Background and aims Sleep disruptions increase the risk of substance misuse. Substance use—especially stimulants—can increase acute and chronic sleep dysfunction. This study aimed to estimate the associations between sleep disturbance and stimulant use over time among participants with stimulant use disorder (StUD).
Viviana E. Horigian, Renae D. Schmidt, Daniel J. Feaster, Rui Duan, Sophia T. Gonzalez, Kathryn Hefner, Dikla Shmueli‐Blumberg, Ashley Vena, Landhing M. Moran, Chloe A. DiCamillo, Shirin Shafazand, Susan Tross, Judith Feinberg   +12 more
wiley   +1 more source

Cannabis-Containing Cream for CKD-Associated Pruritus: A Double-Blind, Placebo Controlled Trial

Kidney Medicine
Rationale & Objective: This study aims to compare the efficacy of a cannabis cream and a placebo in the treatment of chronic kidney disease (CKD)-associated pruritus. Study Design: A double-blind randomized controlled study.
Suthiya Anumas, Pranporn Kuropakornpong, Panlop Chakkavittumrong, Adis Tasanarong, Pattharawin Pattharanitima   +4 more
doaj   +1 more source