High-Throughput LC-MS/MS Quantification of Eighteen Cannabinoids in Hemp Flowers with Baseline Separation of Structural Isomers. [PDF]
Liu N +6 more
europepmc +1 more source
ABSTRACT Background The obesity pharmacotherapy landscape is evolving rapidly, with several approved incretin‐based therapies and an expanding pipeline of investigational compounds targeting multiple metabolic pathways. Conventional evidence syntheses often struggle to accommodate differences in dose selection, treatment duration and stage of clinical ...
Matteo Monami +2 more
wiley +1 more source
ABSTRACT Rationale Cannabinoids comprise a chemically diverse group of meroterpenoids whose extensive isomerism, variable side‐chain length, and frequent oxidative or rearranged derivatives lead to strongly overlapping yet characteristic MS/MS fragmentation patterns. In untargeted LC–MS/MS datasets, this combination of structural diversity and spectral
Julia Maia Galvão de Queiroz +4 more
wiley +1 more source
Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review. [PDF]
Matias EF +2 more
europepmc +1 more source
Ghrelin excites the dentate gyrus (DG) granule cells via GHSR‐mediated modulation of diverse ionic channels and activation of D1R, cAMP, and EPAC2. Similarly, overnight calorie restriction alters neuronal excitability in a ghrelin‐dependent manner. Infusion of ghrelin directly into the DG improves short‐term spatial memory in the Y‐maze, providing ...
Chidiebele S. Oraegbuna +3 more
wiley +1 more source
Cannabinoids in Motor Control: From Receptor Distribution to Motor Disorders. [PDF]
Faganeli D, Lipnik-Stangelj M.
europepmc +1 more source
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report. [PDF]
Ngardig Ngaba N +23 more
europepmc +1 more source
ABSTRACT Acute encephalopathy in patients with prolonged isotretinoin exposure should prompt careful assessment of undisclosed or non‐prescribed medication use. This case suggests a possible association between high cumulative isotretinoin exposure, frequent daily rizatriptan use, and acute encephalopathy, but does not establish a definitive drug–drug ...
Soheil Roshanzamiri +5 more
wiley +1 more source
Cannabinoid Therapy for Refractory Trigeminal Neuropathic Pain: Quantification of Somatosensory Alterations (QualST) by 3D Stereophotogrammetry-Two Case Reports. [PDF]
Mélo AM +7 more
europepmc +1 more source

