Results 171 to 180 of about 59,439 (317)
In vivo evidence for functional selectivity at the CB1 cannabinoid receptor
, 2009 While cannabinoids are generally expected to modulate synaptic communication through depolarisation-induced suppressions of inhibition or excitation (DSI/DSE), we previously reported a CB1 cannabinoid receptor-mediated complex regulation of tyrosine ...
Gordon Research Conferences on Cannabinoid function in the CNS +1 more
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British Journal of Pharmacology, EarlyView.Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus +7 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
یافتههای نوین در علوم زیستی, 2015 There are multiple neurotransmitters and neuromodulator systems mediating memory formation among which the endocannabinoid system plays a critical role in the memory formation by modulating the release of many neurotransmitters. Nucleus accumbens appears
Khalil Rasekhi +3 more
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British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
Progress toward pharmacotherapies for cannabis-use disorder: an evidence-based review
Substance Abuse and Rehabilitation, 2016 Jan Copeland, Izabella Pokorski UNSW Medicine, University of New South Wales, Sydney, NSW, Australia Abstract: Cannabis is the most widely used and variably regulated drug in the world, with increasing trends of use being reported in the US, Australia ...
Copel, J, Pokorski I
doaj
The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source
The effect of CBD(BDS) botanical cannabinoid extraction on MCF-7 human breast carcinoma cells.
, 2011 The use of cannabinoids in cancer treatment has recently attracted attention (Alexander et al., 2009). A number of studies have shown that the apoptosis or reduced growth induced in tumour cells by cannabinoids involves an increase in the expression of
Ayerakwa, L. +4 more
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Fish welfare in a changing world: New developments and current challenges
Journal of Fish Biology, EarlyView.Abstract The welfare of non‐human animals is central to ethical discussions on animal use, with increasing attention to fish welfare across research, aquaria, aquaculture, and fisheries. This paper reviews current theoretical approaches to animal welfare and recent advances in defining and assessing fish welfare since the seminal paper by Huntingford ...
Sonia Rey Planellas +16 more
wiley +1 more source