MedComm, Volume 7, Issue 8, August 2026.1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa +17 more
wiley +1 more source
Acute Effects of Cannabinoid Combination Therapies in a Western Diet-Induced Murine Model of Metabolic Liver Disease. [PDF]
Int J Mol SciLian J, Patil M, Lareu RR, Falasca M.
europepmc +1 more source
Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy
Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley +1 more source
Cannabinoid-Driven Rewiring of GPCR and Ion Channel Signaling in Lung Cancer. [PDF]
BiomedicinesHeriyanto DS +10 more
europepmc +1 more source
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis
The Journal of Pathology, Volume 269, Issue 4-5, Page 462-477, August 2026.Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) and the cannabinoid receptors CB1 and CB2 during AP.
Paula Goncalves‐Romeu +7 more
wiley +1 more source
Circuit-Selective FAAH Inhibition Suppresses Experimental Absence Seizures. [PDF]
CNS Neurosci TherMorais TP +3 more
europepmc +1 more source
The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.CB1 and CB2 receptors are widely distributed in both normal and cancerous cells. Cannabinoids have a positive impact on reducing tumor growth in mice. A positive relationship exists between CB2 receptors and survival in skin melanoma. However, there is a negative impact on non‐small cell lung cancer and colon cancer, whereas a higher association of CB1
Farideh A. Javid +3 more
wiley +1 more source
Propofol Attenuates Brain Ischemic Injury Through the Cannabinoid Type 1 (CB1) Receptor. [PDF]
CureusJia J +6 more
europepmc +1 more source
Chemogenetic Activation of G12 Signaling Thickens the Epidermis With Enhanced Barrier Function
FASEB BioAdvances, Volume 8, Issue 8, August 2026.In this study, we investigated the role of G12 signaling in the epidermis using a keratinocyte‐specific chemogenetic approach. Activation of G12 signaling promoted keratinocyte differentiation and enhanced epidermal barrier function by upregulating filaggrin, claudin‐1, and ceramide.
Nozomi Kamakura +8 more
wiley +1 more source
Chronic simultaneous inducible nitric oxide synthase (iNOS) and peripheral cannabinoid CB<sub>1</sub> receptors blockade ameliorates pulmonary hypertension in monocrotaline-induced rat model. [PDF]
Front PharmacolRyszkiewicz P +6 more
europepmc +1 more source