Results 51 to 60 of about 59,439 (317)

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review

Biology, 2022
Cannabis sativa L. (Cannabis) and its bioactive compounds, including cannabinoids and non-cannabinoids, have been extensively studied for their biological effects in recent decades. Cannabidiol (CBD), a major non-intoxicating cannabinoid in Cannabis, has
Camren G. Heider, Sasha A. Itenberg, Jiajia Rao, Hang Ma, Xian Wu   +4 more
doaj   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

eLife
In T-cell acute lymphoblastic leukemia (T-ALL), more than 50% of cases display autoactivation of Notch1 signaling, leading to oncogenic transformation.
Elazar Besser, Anat Gelfand, Shiri Procaccia, Paula Berman, David Meiri   +4 more
doaj   +1 more source

Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study

Frontiers in Neurology, 2019
Purpose: There is uncertainty regarding the appropriate dose of Cannabidiol (CBD) for childhood epilepsy. We present the preliminary data of seven participants from the Cannabidiol in Children with Refractory Epileptic Encephalopathy (CARE-E) study ...
Richard J. Huntsman, Richard J. Huntsman, Richard Tang-Wai, Richard Tang-Wai, Jane Alcorn, Jane Alcorn, Stephanie Vuong, Bryan Acton, Bryan Acton, Scott Corley, Scott Corley, Robert Laprairie, Robert Laprairie, Andrew W. Lyon, Andrew W. Lyon, Simona Meier, Darrell D. Mousseau, Darrell D. Mousseau, Doris Newmeyer, Erin Prosser-Loose, Blair Seifert, Blair Seifert, Jose Tellez-Zenteno, Jose Tellez-Zenteno, Linda Huh, Edward Leung, Philippe Major   +26 more
doaj   +1 more source

Cannabinoids and their actions [PDF]

British Journal of Pharmacology, 2007
British Journal of Pharmacology (2007) 152, 557–558; doi:10.1038/sj.bjp.0707483; published online 24 September ...
S P H, Alexander, M, Randall
openaire   +2 more sources

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Medical cannabis use in Australia seven years after legalisation: findings from the online Cannabis as Medicine Survey 2022–2023 (CAMS-22)

Harm Reduction Journal
Background Cannabis was legalised for medical purposes in 2016. Uptake was initially slow, but since 2019 there has been a large increase in the number of Australians who have been prescribed cannabis for medical reasons.
Llewellyn Mills, Jonathon C. Arnold, Anastasia Suraev, Sarah V. Abelev, Cilla Zhou, Thomas R. Arkell, Iain S. McGregor, Nicholas Lintzeris   +7 more
doaj   +1 more source

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self‐Reported Drug Use

Drug Testing and Analysis, EarlyView.
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
A. Y. Simão, T. Rosado, M. Barroso, M. Andraus, E. Gallardo   +4 more
wiley   +1 more source

Cannabinoids and neuroinflammation [PDF]

British Journal of Pharmacology, 2004
Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. This review discusses the anti‐inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti‐inflammatory effects of cannabinoids obtained using ...
Lisa, Walter, Nephi, Stella
openaire   +2 more sources