Results 81 to 90 of about 59,439 (317)

Dendritic Cell Regulation by Cannabinoid-Based Drugs

Pharmaceuticals, 2010
Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have produced promising results using cannabinoid-based drugs for the treatment of obesity and ...
Mattias Svensson, Puran Chen, Oscar Hammarfjord   +2 more
doaj   +1 more source

Purification and characterization of heterologously produced cannabinoid receptor 1 and G proteins

, 2007
G protein coupled receptors form the largest group of transmembrane proteins, which are involved in signal transduction and are targeted directly or indirectly by 40-50% of the drugs in the market.
Chillakuri, Chandramouli, Chillakuri, C.
core  

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

The Effect of Cannabidiol on Subjective Responses to Endurance Exercise: A Randomised Controlled Trial

Sports Medicine - Open
Background Exercise is known to improve health. However, it can be unpleasant, often inducing negative feelings, or ‘affect’. Cannabidiol (CBD), a non-intoxicating constituent of the cannabis plant, has been reported to enhance the subjective experience ...
Danielle McCartney, Christopher Irwin, Zeeta Bawa, Blake Palmer, Ayshe Sahinovic, Nathan Delang, Gregory R. Cox, Ben Desbrow, Namson S. Lau, Iain S. McGregor   +9 more
doaj   +1 more source

Effects of cannabidiol on psychosocial stress, situational anxiety and nausea in a virtual reality environment: a protocol for a single-centre randomised clinical trial

BMJ Open
Introduction The non-intoxicating plant-derived cannabinoid, cannabidiol (CBD), has demonstrated therapeutic potential in a number of clinical conditions. Most successful clinical trials have used relatively high (≥300 mg) oral doses of CBD.
Iain S McGregor, Richard Fox, Hamish MacDougall, Danielle McCartney, Zeeta Bawa, Miguel Bedoya-Pérez, Namson S Lau   +6 more
doaj   +1 more source

Saturated Cannabinoids: Update on synthesis strategies and biological studies of these emerging cannabinoid analogs.

, 2023
Natural and non-natural hexahydrocannabinols (HHC) were first described in 1940 by Adam and in late 2021 arose on the drug market in the United States and in some European countries.
Alex, Okhovat, Monica, Pittiglio, Westley, Cruces, Tesfay, Tesfatsion, Giovanni, Ramirez, Maite, Docampo-Palacios, Kyle, Ray   +6 more
core   +1 more source

Chemical Ionization Mass Spectrometry: Fundamental Principles, Diverse Applications, and the Latest Technological Frontiers

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The review examines the evolution of chemical ionization mass spectrometry (CI‐MS), a technique developed in 1966 by Field and Munson. CI is a soft‐ionization method that produces more intense molecular ions with less fragmentation than electron ionization (EI).
Malvika Dutt, Adriana Arigò, Giorgio Famiglini, Pierangela Palma, Achille Cappiello   +4 more
wiley   +1 more source

Pharmacological and physiological effects of cannabidiol: a dose escalation, placebo washout study protocol

BMC Neurology
Background Cannabinoids such as cannabidiol (CBD) exhibit anti-inflammatory properties and have the potential to act as a therapeutic following mild traumatic brain injury.
J. Patrick Neary, Jyotpal Singh, Jane Alcorn, Robert B. Laprairie, Payam Dehghani, Cameron S. Mang, Bruce H. Bjornson, Thomas Hadjistavropoulos, Holly A. Bardutz, Lanishen Bhagaloo, Zachary Walsh, Michael Szafron, Kim D. Dorsch, Elizabeth S. Thompson   +13 more
doaj   +1 more source

Cardio-renal effects of chronic administration with CB2 agonist AM1241 and CB2 antagonist AM630 in rats with diet induced obesity

, 2013
It is widely recognised that obesity elicits a number of comorbidities including heart and kidney disease. The progression of these diseases is frequently exacerbated by other clinical factors associated with obesity such as hypertension and metabolic ...
Mathai, Michael L., McAinch, Andrew J., Simcocks, Anna, O'Keefe, Lannie, Hryciw, Deanne H., Jenkin, Kayte A. (R19563)   +5 more
core  

Classification of Cannabinoid Spectra Using Machine Learning

, 2022
Vibrational spectroscopy, encompassing Raman and Infrared (IR) spectroscopy, is a powerful technique that probes the intrinsic vibrations of a molecule, thus providing a unique chemical signature for that molecule.
Gianluca, Serra, Nisha Rani, Agarwal, Miguel, Lozano, Matteo, Tommasini, Narayan, Kabra, Karthik, Sankaranarayanan   +5 more
core   +1 more source