Results 171 to 180 of about 247,999 (295)

Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies

open access: yesCancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Fetal calf serum (FCS) is a key supplement in cell culture, providing nutrients, and growth factors that support cancer cell proliferation. Studies suggest that compound cytotoxicity profiles in vitro vary depending on FCS concentration in culture medium. The study aimed to examine how extracellular conditions influence the in vitro
Sanele Priscillia Mathibela   +2 more
wiley   +1 more source

Cannabichromene variation in hemp cultivars

open access: yesCrop Science, Volume 66, Issue 2, March/April 2026.
Abstract Cannabichromene (CBC) is a nonpsychoactive cannabinoid with pharmaceutical potential that is attracting significant interest for its potential therapeutic applications. However, the factors governing CBC production in Cannabis sativa remain largely unknown. This study aimed to investigate the variation in CBC accumulation within different Type
Anthony Torres   +6 more
wiley   +1 more source

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

open access: yesDevelopmental Dynamics, Volume 255, Issue 3, Page 321-339, March 2026.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino   +3 more
wiley   +1 more source

Differential Alterations in Offset Analgesia and Conditioned Pain Modulation in Fibromyalgia: Evidence for Distinct Central Dysregulation

open access: yesEuropean Journal of Pain, Volume 30, Issue 3, March 2026.
ABSTRACT Background Chronic pain often involves abnormalities in central pain processing. Two commonly used experimental methods for central pain modulation are conditioned pain modulation (CPM) and offset analgesia (OA). However, it is uncertain how similar the underlying processes they measure are.
Yara Agbaria   +5 more
wiley   +1 more source

Milk Fat Globule Membrane Supplementation Attenuates Cognitive Impairment in APP/PS1 Mice via Suppressing Neuroinflammation in a Gut Microbiota‐Mediated Serum Resolvin D1/Anandamide Manner

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
MFGM modulated gut microbiota accompanied by the increased serum RVD1 and AEA levels, which subsequently regulated the miRNA profile. This modulation alleviated neuroinflammation via suppressing the NLRP3 inflammasome signaling and microglial activation, thereby attenuating AD‐related cognitive impairment both in vivo and in vitro.
Han Gong   +4 more
wiley   +1 more source

Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva   +9 more
wiley   +1 more source

Upstream CB1R Regulation of β‐Adrenergic Memory Consolidation

open access: yesHippocampus, Volume 36, Issue 2, March 2026.
ABSTRACT Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β‐adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus.
Janine I. Rossato   +9 more
wiley   +1 more source

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.

open access: yesNeuropharmacology, 2017
Leepakshi Khurana   +3 more
semanticscholar   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

open access: yesIbrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

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