Results 181 to 190 of about 247,999 (295)

Progress in Gastroparesis Management: From Pharmacotherapy to Interventional Treatments

open access: yesJGH Open, Volume 10, Issue 3, March 2026.
ABSTRACT Gastroparesis is a sensorimotor condition characterized by delayed gastric emptying without any obvious mechanical obstruction. Common symptoms include early satiety, nausea, vomiting, belching, and bloating. The most frequent causes of gastroparesis are diabetes, idiopathic factors, and post‐surgical complications.
Ganesh Kumar   +9 more
wiley   +1 more source

Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple‐Masked, Randomized, Placebo‐Controlled Phase 2 Trial

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 6, 29 March 2026.
Adults with active Crohn's disease (n = 20) received 24 mg/day of xanthohumol (XN), a bioactive compound derived from Humulus lupulus (hops), for 8 weeks. The study evaluated safety and tolerability through clinical laboratory measures, adverse events, vital signs, anthropometrics, health−related quality of life, and adherence.
Ryan Bradley   +5 more
wiley   +1 more source

Current and Emerging Pharmacologic Therapies for Diabetic Retinopathy

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin levels, hypertension, and dyslipidemia, with rapid glucose reduction also increasing risk for developing ...
Jennifer N. Clements   +2 more
wiley   +1 more source

Illicit Drug‐Derived Volatile Organic Compounds as Markers for Application in Noncontact Detection Technology

open access: yesThe Chemical Record, Volume 26, Issue 3, March 2026.
This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim   +4 more
wiley   +1 more source

The role of accessory proteins and co‐factors in regulation of melanocortin‐4 receptor signalling: An update

open access: yesJournal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The melanocortin‐4 receptor (MC4R) is a G protein‐coupled receptor with an essential role in appetite suppression and energy homeostasis. Genetic mutations in the receptor and components of its signalling pathway that cause obesity in humans, dogs and rodent models have revealed important insights into how the receptor signals and what ...
Aqfan Jamaluddin   +3 more
wiley   +1 more source

Insights into glandular trichome biology from analysis of organ‐specific gene expression programmes in cannabis, hop and tomato

open access: yesThe Plant Journal, Volume 125, Issue 6, March 2026.
Significance Statement This study of three glandular trichome‐producing species (cannabis, hop and tomato) defines tissue‐specific transcriptomic atlases for five organs (trichome, flower, leaf, stem and root), providing co‐expression and gene regulatory networks and identifying candidate regulators of specialised metabolism in trichomes of each ...
Muluneh Tamiru‐Oli   +10 more
wiley   +1 more source

Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms. [PDF]

open access: yesInt J Mol Sci
Saldaña R   +5 more
europepmc   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

open access: yesTraffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang   +7 more
wiley   +1 more source

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