Results 221 to 230 of about 6,065 (241)

Sleep modulates cannabinoid receptor 1 expression in the pons of rats

Neuroscience, 2003
Endocannabinoids seem to play a role in the modulation of alertness. Therefore, we measured cannabinoid receptor 1 (CB1R) protein by Western blot and messenger RNA (mRNA) by reverse transcription-polymerase chain reaction in the pons of rats across the 24-h period. We performed evaluations every 4 h beginning at 09:00 h.
M, Martínez-Vargas, E, Murillo-Rodríguez, R, González-Rivera, A, Landa, M, Méndez-Díaz, O, Prospro-García, L, Navarro   +6 more
openaire   +2 more sources

Cannabinoid Receptor Modulation of Synapses Received by Cerebellar Purkinje Cells

Journal of Neurophysiology, 2000
The high density of cannabinoid receptors in the cerebellum and the degradation of motor coordination produced by cannabinoid intoxication suggest that synaptic transmission in the cerebellum may be strongly regulated by cannabinoid receptors. Therefore the effects of exogenous cannabinoids on synapses received by Purkinje cells were investigated in ...
K A, Takahashi, D J, Linden
openaire   +2 more sources

Negative allosteric modulators of cannabinoid receptor 1: Ternary complexes including CB1, orthosteric CP55940 and allosteric ORG27569

Journal of Biomolecular Structure and Dynamics, 2022
Pankaj Pandey, Robert J Doerksen
exaly  

Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure

Bioorganic and Medicinal Chemistry, 2021
Sumanta Garai, Robert B Laprairie, David R Janero   +2 more
exaly  

Selective cannabinoid receptor 2 modulators: a patent review 2009 – present

Expert Opinion on Therapeutic Patents, 2012
Doris Riether
exaly  

Exploring 6-Azaindole and 7-Azaindole Rings for Developing Cannabinoid Receptor 1 Allosteric Modulators

Cannabis and Cannabinoid Research, 2018
Sri Sujana Immadi, Zhixing Wu, Debra A Kendall   +2 more
exaly  

Allosteric Modulation of the Cannabinoid CB1 Receptor

2017
E.E. Cawston, M.R. Hunter, M. Glass
openaire   +1 more source

Crystal Structure of the Human Cannabinoid Receptor CB1

Cell, 2016
Tian Hua, Kiran Vemuri, Mengchen Pu
exaly  

Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor

Angewandte Chemie - International Edition, 2018
Noureldin Saleh, Timothy Clark, Peter W Hildebrand   +2 more
exaly  

Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor

European Journal of Medicinal Chemistry, 2016
Hamed I Ali, Kwang H Ahn, Debra A Kendall   +2 more
exaly