Molecular Insights into Epigenetics and Cannabinoid Receptors [PDF]
Biomolecules, 2022 The actions of cannabis are mediated by G protein-coupled receptors that are part of an endogenous cannabinoid system (ECS). ECS consists of the naturally occurring ligands N-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), their ...
Balapal S. Basavarajappa +1 more
doaj +2 more sources
Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors [PDF]
Communications Biology, 2023 Design of cannabinergic subtype selective ligands is challenging because of high sequence and structural similarities of cannabinoid receptors (CB1 and CB2).
Soumajit Dutta, Diwakar Shukla
doaj +2 more sources
Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic Dermatitis [PDF]
Frontiers in Veterinary Science, 2022 It is commonly accepted that some form of skin barrier dysfunction is present in canine atopic dermatitis (AD), one of the most common cutaneous pruritic inflammatory diseases of dogs.
Roberto Chiocchetti +7 more
doaj +2 more sources
The Vertical and Horizontal Pathways in the Monkey Retina Are Modulated by Typical and Atypical Cannabinoid Receptors [PDF]
Cells, 2021 The endocannabinoid (eCB) system has been found in all visual parts of the central ner-vous system and plays a role in the processing of visual information in many species, including monkeys and humans. Using anatomical methods, cannabinoid receptors are
Joseph Bouskila +4 more
doaj +2 more sources
The cannabinoid receptors system in horses: Tissue distribution and cellular identification in skin [PDF]
Journal of Veterinary Internal Medicine, 2022 Background The endocannabinoid system (ECS) is composed of cannabinoid receptors type 1 (CBR1) and type 2 (CBR2), cannabinoid‐based ligands (endogenous chemically synthesized phytocannabinoids), and endogenous enzymes controlling their concentrations ...
Piotr Kupczyk +9 more
doaj +2 more sources
Current Biology, 2002 Abstract Cannabinoid receptors are seven transmembrane receptors that mediate the central and peripheral actions of extracts from the cannabis plant. Although many endogenous agonists of cannabinoid receptors have been described, a categorical role of these (mainly fatty acid derived) molecules as the endogenous ligand for cannabinoid ...
D A Kendall, S P H Alexander
+5 more sources
Russian Open Medical Journal, 2023 Publication interest in cannabinoids, including phytocannabinoids, endogenous cannabinoids, synthetic cannabinoids and cannabinomimetic compounds, is due to the therapeutic potential of these compounds in inflammatory pathology.
Oksana Yu. Kytikova +3 more
doaj +1 more source
The Endocannabinoid System Contributes to Electroacupuncture Analgesia
Frontiers in Neuroscience, 2021 The extensive involvement of the endocannabinoid system (ECS) in vital physiological and cognitive processes of the human body has inspired many investigations into the role of the ECS and drugs, and therapies that target this system and its receptors ...
Iona J. MacDonald +3 more
doaj +1 more source
Cannabinoid and Cannabinoid-Related Receptors in the Myenteric Plexus of the Porcine Ileum
Animals, 2021 An important piece of evidence has shown that molecules acting on cannabinoid receptors influence gastrointestinal motility and induce beneficial effects on gastrointestinal inflammation and visceral pain.
Andrea Toschi +6 more
doaj +1 more source
Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]
, 2012 BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen +8 more
core +7 more sources