Results 151 to 160 of about 56,314 (199)
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Prostaglandins & Other Lipid Mediators, 2002
Cannabinoid receptors were named because they have affinity for the agonist delta9-tetrahydrocannabinol (delta9-THC), a ligand found in organic extracts from Cannabis sativa. The two types of cannabinoid receptors, CB1 and CB2. are G protein coupled receptors that are coupled through the Gi/o family of proteins to signal transduction mechanisms that ...
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Cannabinoid receptors were named because they have affinity for the agonist delta9-tetrahydrocannabinol (delta9-THC), a ligand found in organic extracts from Cannabis sativa. The two types of cannabinoid receptors, CB1 and CB2. are G protein coupled receptors that are coupled through the Gi/o family of proteins to signal transduction mechanisms that ...
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CB1 Cannabinoid Receptor Ligands
Mini-Reviews in Medicinal Chemistry, 2005The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications.
Ganesh A, Thakur +2 more
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Cannabinoid receptors and immunity
Immunology Today, 1998Abstract Marijuana cannabinoids are both psychoactive and immunoactive. Here, we will review evidence that cannabinoids modulate immunity and that cannabinoid receptors and endogenous ligands are expressed in immune tissues. Clues will also be presented concerning the role of the cannabinoid system in immune regulation and the possible molecular ...
T W, Klein, C, Newton, H, Friedman
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Characterization of Cannabinoid Receptors
Current Protocols in Pharmacology, 2002AbstractThis unit describes the use of cannabinoid radioligands in competitive binding assays for determining affinity parameters (IC50,Ki) of unlabeled compounds at transfected CB1 and CB2 receptors expressed in cell lines.Curr. Protoc. Pharmacol. 63:1.26.1‐1.26.10. © 2013 by John Wiley & Sons, Inc.
Richard F, Cox, Vincent, Rash
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Cannabinoid Receptor Signaling
2005The cannabinoid receptor family currently includes two types: CB1, characterized in neuronal cells and brain, and CB2, characterized in immune cells and tissues. CB1 and CB2 receptors are members of the superfamily of seven-transmembrane-spanning (7-TM) receptors, having a protein structure defined by an array of seven membrane-spanning helices with ...
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Cannabis and cannabinoid receptors
Fitoterapia, 2000Cannabis and cannabinoids exert many of their biological functions through receptor-mediated mechanisms. Two types of cannabinoid receptors have been identified, namely CB(1) and CB(2), both coupled to a G protein. CB(1) receptors have been detected in the central nervous system (where they are responsible for the characteristic effects of Cannabis ...
E. Nocerino +2 more
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Cannabinoid receptors in atherosclerosis
Current Opinion in Lipidology, 2006Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed.Cannabinoids, such as Delta9-tetrahydrocannabinol, the major psychoactive compound of marijuana, their synthetic analogs and endogenous cannabinoid ligands, produce their biological effects by interacting with specific receptors.
Sabine, Steffens, Francois, Mach
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Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes
Chemistry and Physics of Lipids, 2002Delta(9)-Tetrahydrocannabinol (delta(9)-THC), the primary psychoactive constituent of marijuana (Cannabis sativa), is known to bind to two cannabinoid receptors: CB(1) receptors, located primarily in the brain, and CB(2) receptors, located primarily in the periphery.
Jenny L, Wiley, Billy R, Martin
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Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists
Biochemical Pharmacology, 2019Cannabinoid receptors type 1 (CB1) and type 2 (CB2) are promising targets for a number of diseases, including obesity, neuropathic pain, and multiple sclerosis, among others. Upon ligand-mediated activation of these receptors, multiple receptor conformations could be stabilized, resulting in a complex pattern of possible intracellular effects. Although
Elise Wouters +3 more
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Canonical Cannabinoid Receptors
This chapter will review the basic pharmacology of the canonical cannabinoid receptors. The endocannabinoid system is a complex signalling network involved in a wide range of physiological processes, including pain modulation, appetite regulation, and synaptic plasticity.Beth, Ehrlich +3 more
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