Results 101 to 110 of about 122,153 (397)

Market Analysis of Plant-based Drugs C. The Cannabis Market [PDF]

, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core  

Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]

, 2016
The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio, Daugherty, Daniel, M Armando, Aaron, Maher, Pam, Quehenberger, Oswald, Schubert, David   +5 more
core   +2 more sources

Cannabinoids in cancer treatment: Therapeutic potential and legislation.

Bosnian Journal of Basic Medical Sciences, 2019
The plant Cannabis sativa L. has been used as an herbal remedy for centuries and is the most important source of phytocannabinoids. The endocannabinoid system (ECS) consists of receptors, endogenous ligands (endocannabinoids) and metabolizing enzymes ...
B. Dariš, Mojca Tancer Verboten, Ž. Knez, P. Ferk   +3 more
semanticscholar   +1 more source

Cannabinoids and haemostasis

Postępy Higieny i Medycyny Doświadczalnej, 2016
Elements of the endocannabinoid system (cannabinoid receptors CB1, CB2, CBPT and CBED, endocannabinoids, enzymes involved in the synthesis and metabolism of endocannabinoids) are located on the structures involved in the process of hemostasis. An increasing level of endocannabinoids was also observed in some pathological conditions, which may occur in ...
Agnieszka, Zakrzeska, Tomasz, Grędziński, Wioleta, Kisiel, Ewa, Chabielska   +3 more
openaire   +2 more sources

Associations of U.S. state-level COVID-19 policies intensity with cannabis sharing behaviors in 2020

Harm Reduction Journal
Background Cannabis use before the COVID-19 pandemic for many involved sharing prepared cannabis for inhalation, practices that were less prevalent during the pandemic. State-level COVID-19 containment policies may have influenced this decrease.
Ryan D. Assaf, Rita Hamad, Marjan Javanbakht, Onyebuchi A. Arah, Steven J. Shoptaw, Ziva D. Cooper, Pamina M. Gorbach   +6 more
doaj   +1 more source

Cannabinoids in Late Life Parkinson’s Disease and Dementia: Biological Pathways and Clinical Challenges

Brain Sciences, 2022
The use of cannabinoids as therapeutic drugs has increased among aging populations recently. Age-related changes in the endogenous cannabinoid system could influence the effects of therapies that target the cannabinoid system.
Alana C. Costa, Helena P. G. Joaquim, João F. C. Pedrazzi, Andreia de O. Pain, Gustavo Duque, Ivan Aprahamian   +5 more
doaj   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, Manjunath S. Shet, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]

, 2015
Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim, Andradas, Clara, Arnold, Norbert, Artola, Marta, Bauer, Maret, Blasco-Benito, Sandra, Bronsert, Peter, Caffarel, María M., Canela, Enric I., Fernández-Piqueras, José, Flores, Juana M., García-Taboada, Elena, Guzmán, Manuel, Hamann, Sigrid, Klapper, Wolfram, Martín-Villar, Ester, McCormick, Peter J., Megías, Diego, Moreno, Estefanía, Moreno-Bueno, Gema, Ortega-Gutiérrez, Silvia, Pérez-Gómez, Eduardo, Pérez-Martínez, Manuel, Quintanilla, Miguel, Röcken, Christoph, Soriano, Joaquim, Staebler, Annette, Stickeler, Elmar, Sánchez, Cristina, Villa-Morales, María, Vázquez-Villa, Henar, Wenners, Antonia   +31 more
core   +1 more source

Cannabinoids—Multifunctional Compounds, Applications and Challenges—Mini Review

Molecules
Cannabinoids represent a highly researched group of plant-derived ingredients. The substantial investment of funds from state and commercial sources has facilitated a significant increase in knowledge about these ingredients.
Dominik Duczmal, Aleksandra Bazan-Wozniak, Krystyna Niedzielska, Robert Pietrzak   +3 more
doaj   +1 more source