Results 81 to 90 of about 47,203 (289)
Communications Biology, 2022 Synthetic cannabinoids are amongst the most widely used psychoactive drugs which are tightly controlled by government agencies around the world. Here, pharmacokinetics of two synthetic cannabinoids in rats are evaluated along with their metabolites and ...
David Fabregat-Safont +8 more
doaj +1 more source
The Role of Nitrous Oxide (“Laughing Gas”) in DUID Cases and Its Impact on Driving Fitness
Drug Testing and Analysis, EarlyView.A total number of 39 cases of driving under the influence of nitrous oxide were investigated. Plasma concentrations of 0.22 to 17 mL/L (median:3.7 mL/L) were measured in blood samples withdrawn 38 to 144 min (median: 85 min) after control via Headspace‐GC–MS.
L. Lucuta +4 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Scalp hair from a subject claiming 2‐year abstinence tested positive for MDMB‐4en‐PINACA and other synthetic cannabinoids. Analysis of the worn baseball cap revealed an identical drug profile, demonstrating external contamination – rather than active use – as the likely source and highlighting a critical pitfall in hair‐based abstinence testing ...
Annette Zschiesche +5 more
wiley +1 more source
The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study [PDF]
, 2006 Gating of sensory (e.g. auditory) information has been demonstrated as a reduction in the auditory-evoked potential responses recorded in the brain of both normal animals and human subjects.
Mason, Rob +9 more
core +1 more source
Nightmares and the Cannabinoids [PDF]
Current Neuropharmacology, 2020 :The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow.
openaire +2 more sources
BMJ Case Reports, 2010 A 21-year-old woman presented with a 4-week history of sudden onset vomiting, nausea and anorexia. Questioning revealed that she had a 7-year history of heavy cannabis use (smoking). She did not describe abdominal pain, change in bowel habit, antibiotic use, foreign travel or contact with gastroenteritis.
Kim, Wild, Hugh, Wilson
openaire +3 more sources
Efficient Synthesis of Cannabinoid Acids
European Journal of Organic Chemistry, EarlyView.In this study, an alternative synthesis of cannabinoid acids was developed based on an O→C acyl rearrangement. Specifically, this strategy involved regioselective bromination followed by halogen–lithium exchange and intramolecular nucleophilic addition, which led to successful carboxylation.
Ryosuke Arai +8 more
wiley +1 more source
Frequent cannabis use and the association with seizure burden in drug‐resistant epilepsy
Epilepsia, EarlyView.Abstract Objective Cannabis use has increased substantially, with modern products characterized by high tetrahydrocannabinol concentrations and variable composition. The relationship between frequent cannabis use and epilepsy outcomes remains uncertain. We examined the association between frequent cannabis use and epilepsy severity, clinical phenotype,
Santiago Philibert‐Rosas +16 more
wiley +1 more source
Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care
Epilepsia Open, EarlyView.Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley +5 more
wiley +1 more source
Analgesic use, safety and pharmacokinetics of acetaminophen in equids: A structured scoping review
Equine Veterinary Journal, EarlyView.Abstract Background Despite its frequent use in equine clinical practice, scientific data on the use of acetaminophen in horses remain limited. Objective To map and critically appraise the available evidence on the analgesic use, safety and pharmacokinetics of acetaminophen in horses. Study Design Structured scoping review.
Francisco Medina‐Bautista +2 more
wiley +1 more source