Results 61 to 70 of about 47,203 (289)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Cannabinoids in the Older Person: A Literature Review

Geriatrics, 2020
Introduction: Medical cannabinoids have received significant mainstream media attention in recent times due to an evolving political and clinical landscape.
William Beedham, Magda Sbai, Isabel Allison, Roisin Coary, David Shipway   +4 more
doaj   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source

Mobile EEG examination of putative biomarkers of mental health in individuals that use cannabis

NPP-Digital Psychiatry and Neuroscience
Healthy individuals that use cannabis are at greater risk of developing mental health conditions than those that do not use cannabis. Here, using mobile electroencephalography (EEG) in controlled laboratory settings, we examined two putative biomarkers ...
Conor H. Murray, Kaihan Danesh, Ziva D. Cooper   +2 more
doaj   +1 more source

Perspectives on drugs: Synthetic cannabinoids in Europe. [PDF]

, 2015
Synthetic cannabinoids represent the largest group of compounds currently monitored in Europe by the EU Early warning system on new psychoactive substances. Current knowledge on these substances, as well as trends in production, availability and use, are

core  

Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice [PDF]

, 2012
Background/Aims: Compounds of Cannabis sativa are known to exert anti-inflammatory properties, some of them without inducing psychotropic side effects. Cannabidiol (CBD) is such a side effect-free phytocannabinoid that improves chemically induced colitis
Martin Storr, Storr, Martin, Rudolf Schicho, Schicho, Rudolf   +3 more
core   +1 more source

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi   +9 more
wiley   +1 more source

Emerging Psychedelics: A Systematic Review of Synthetic Cannabinoids [PDF]

Research on Addiction, 2020
Objective: In recent years, the advent of synthetic cannabinoids, deceptive advertising and cyber sales has led young people to use them. The United Nations Office on Drugs and Crime (UNODC) has identified the prevalence of using these compounds as a ...
samad shokuhi-rad, ebrahim ghorbani
doaj  

Medical Use of Cannabinoids

, 2018
Cannabinoid receptors, endocannabinoids and the enzymes responsible for their biosynthesis and degradation constitute the endocannabinoid system. In recent decades, the endocannabinoid system has attracted considerable interest as a potential therapeutic
Fraguas Sánchez, Ana Isabel, Torres Suárez, Ana Isabel   +1 more
core   +1 more source