Results 81 to 90 of about 82,568 (267)

Modifiable Transdiagnostic Risk and Protective Factors as Potential CBT Augmentation Targets for Eating Disorders: An Updated Umbrella Review

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective A focus on transdiagnostic targets is one of the key strategies for developing effective, efficient, and scalable treatments for mental health conditions. We conducted an umbrella review of recent meta‐analyses (August 2022 to May 2026) to update our understanding of critical transdiagnostic intervention targets that could inform ...
Yuan Zhou, Marcela Radunz, Tracey D. Wade   +2 more
wiley   +1 more source

High CBD extract (CBD-X) modulates inflammation and immune cell activity in rheumatoid arthritis

Frontiers in Immunology
IntroductionRheumatoid arthritis (RA) is a debilitating autoimmune disease affecting approximately 1% of the global population and is associated with significant morbidity and mortality.
Miran Aswad, Antonina Pechkovsky, Narmeen Ghanayiem, Haya Hamza, Igal Louria-Hayon, Igal Louria-Hayon   +5 more
doaj   +1 more source

Efficient Synthesis of Cannabinoid Acids

European Journal of Organic Chemistry, EarlyView.
In this study, an alternative synthesis of cannabinoid acids was developed based on an O→C acyl rearrangement. Specifically, this strategy involved regioselective bromination followed by halogen–lithium exchange and intramolecular nucleophilic addition, which led to successful carboxylation.
Ryosuke Arai, Hikari Nishiguchi, Kayo Nakamura, Hiroko Abe, Akihiko Ishida, Manabu Tokeshi, Kyohei Higashi, Akiyoshi Saitoh, Hideyo Takahashi   +8 more
wiley   +1 more source

High-CBD Extract (CBD-X) in Asthma Management: Reducing Th2-Driven Cytokine Secretion and Neutrophil/Eosinophil Activity

Pharmaceuticals
Background/Objectives: Asthma is a chronic inflammatory disorder of the airways affecting over 10% of the global population. It is characterized by airway inflammation, mucus hypersecretion, and bronchial hyperresponsiveness, driven predominantly by type
Miran Aswad, Antonina Pechkovsky, Narmeen Ghanayiem, Haya Hamza, Yaniv Dotan, Igal Louria-Hayon   +5 more
doaj   +1 more source

Frequent cannabis use and the association with seizure burden in drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective Cannabis use has increased substantially, with modern products characterized by high tetrahydrocannabinol concentrations and variable composition. The relationship between frequent cannabis use and epilepsy outcomes remains uncertain. We examined the association between frequent cannabis use and epilepsy severity, clinical phenotype,
Santiago Philibert‐Rosas, Kaitlin A. Guston, Mariel Kalkach‐Aparicio, Abigail Keller, Sanaa Semia, Theodore Imhoff‐Smith, Cameron J. Brace, Steven E. Haworth, Felipe Branco de Paiva, Dace Almane, Jonathan Williams, Anne Josiah, Bradley Nix, Bruce P. Hermann, Nagesh Adluru, Jana E. Jones, Aaron F. Struck   +16 more
wiley   +1 more source

Cannabis [PDF]

Der Schmerz, 2019
Peter, Cremer-Schaeffer, Winfried, Häuser   +1 more
openaire   +2 more sources

Neurometabolite abnormalities and associations with epilepsy duration and cognition in patients with idiopathic generalized epilepsies

Epilepsia Open, EarlyView.
Abstract Objective This study investigated whether idiopathic generalized epilepsies (IGEs) are associated with neuroinflammation by measuring neurometabolite levels and brain temperature using whole‐brain magnetic resonance spectroscopy imaging (MRSI).
Yun Lien, Christina Bankston, Ayushe A. Sharma, Brandon S. Mitchell, Rodolphe Nenert, Anna Moyana, Jennifer Pilkington, Roy C. Martin, Charity J. Morgan, Lawrence Ver Hoef, Jerzy P. Szaflarski, Jane B. Allendorfer   +11 more
wiley   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Cannabigerol (CBG) Modulates Neutrophil Activity and Ameliorates Rheumatoid Arthritis Pathogenesis

Pharmaceuticals
Background/Objectives: Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease that primarily affects the joints. Current treatments aim to relieve pain and limit joint damage; however, many are associated with significant side effects ...
Miran Aswad, Antonina Pechkovsky, Haya Hamza, Igal Louria-Hayon   +3 more
doaj   +1 more source

Adolescent Withdrawn/Depressed Symptoms: A Pathway From Early Adversity to Later Marijuana Use

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adverse childhood experiences (ACEs) are robust predictors of marijuana use, yet the developmental mechanisms remain unclear. Building on prior cross‐sectional studies using broad internalizing composites, this study prospectively distinguishes withdrawn/depressed from anxious/depressed symptoms as candidate mediators across ...
Mahsa P. Yousefkhani, Sara A. Vasilenko, Rachel A. Razza   +2 more
wiley   +1 more source